2021
DOI: 10.3389/fnins.2021.697909
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Dysfunctional Brain Dynamics of Parkinson's Disease and the Effect of Acute Deep Brain Stimulation

Abstract: Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, and deep brain stimulation (DBS) can effectively alleviate PD symptoms. Although previous studies have detected network features of PD and DBS, few studies have considered their dynamic characteristics.Objective: We tested two hypotheses. (1) Reduced brain dynamics, as evidenced by slowed microstate dynamic change, is a characteristic of PD and is related to the movement disorders of patients wi… Show more

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Cited by 4 publications
(4 citation statements)
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“…Several studies have explored state-wise functional connectivity in different scenarios ( Comsa et al, 2019 ; Duc and Lee, 2019 ), but the connectivity pattern corresponding to each microstate class in the resting state is still unclear. In addition, according to previous studies, each microstate template has distinct topographic distribution and bright characteristics ( Michel and Koenig, 2018 ; Li et al, 2021 ; Zanesco et al, 2021 ). Therefore, we assumed that each microstate class corresponds to a unique pattern of functional connectivity.…”
Section: Introductionmentioning
confidence: 81%
“…Several studies have explored state-wise functional connectivity in different scenarios ( Comsa et al, 2019 ; Duc and Lee, 2019 ), but the connectivity pattern corresponding to each microstate class in the resting state is still unclear. In addition, according to previous studies, each microstate template has distinct topographic distribution and bright characteristics ( Michel and Koenig, 2018 ; Li et al, 2021 ; Zanesco et al, 2021 ). Therefore, we assumed that each microstate class corresponds to a unique pattern of functional connectivity.…”
Section: Introductionmentioning
confidence: 81%
“…Recent research of acute post-operative DBS effect on brain dynamics 29 found no changes in EEG microstates exclusively caused by DBS; however, according to the authors, the stable and obvious effect of DBS on brain networks is a result of long-term treatment influence and neural plasticity 5,29,45 .…”
Section: Discussionmentioning
confidence: 99%
“…The effect of dopaminergic treatment was also reported 28 . To our knowledge, only one study describes EEG microstates in patients treated by DBS; 29 in that study, the explored effect of DBS was evaluated immediately in the first day of DBS treatment.…”
Section: Introductionmentioning
confidence: 99%
“…2017 ). A prior study revealed that individuals with Parkinson’s disease exhibit prolonged MS durations and lower occurrences compared with healthy individuals ( Li et al. 2021b ).…”
Section: Discussionmentioning
confidence: 99%