Mindfulness-based interventions modulate structural network strength in patients with opioid dependence

Fahmy, Reham; Wasfi, Maha; Mamdouh, Rania; Moussa, Kareem; Wahba, Ahmed; Wittemann, Miriam; Hirjak, Dušan; Kubera, Katharina M.; Wolf, Nadine D.; Sambataro, Fabio

doi:10.1016/j.addbeh.2018.02.013

Cited by 17 publications

(18 citation statements)

References 56 publications

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“…The ALE meta-analysis reveals a significant cluster over the right anterior insula, going over the extreme capsule to the claustrum, an overlap from ROI from Fahmy et al ( 2018 - opioid patients meditators > opioid patients control in the claustrum), Hernández et al ( 2016 - mediators > controls in the short insula gyrus) and Murakami et al ( 2012 - correlation with mindfulness in the short insula gyrus), a sub-region typically associated with emotion (Kurth et al 2010 ). Lazar and colleagues ( 2005 ) were the first to observe important structural changes associated with sustained meditation practice in this region (although not included in the ALE analysis because no coordinates were reported in the article), but also the auditory, somato-sensorial and prefrontal cortices.…”

Section: Discussionmentioning

confidence: 80%

“…Most likely that info was obtained by interviewing participants X ✓ Engen et al 2018 ✓ ✓ X ✓? No mention of blinding Fahmy et al 2018 ✓ ✓MBI which was adapted from the original MBSR ✓ ? No mention of blinding, but also no mention of manual input Fayed et al 2017 ✓ ✓ X X (check in text citations to match this) Friedel et al 2015 X ✓ ✓ (245 agreed, 82 final) ✓ Grant et al 2010 ✓ ✓ X X Grant et al 2013 ✓ ✓ X X Hernandez et al 2016 ✓ ✓ X ?…”

Section: Resultsmentioning

confidence: 99%

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Mindfulness related changes in grey matter: a systematic review and meta‐analysis

Pernet

Белов

Delorme

et al. 2021

Brain Imaging and Behavior

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Knowing target regions undergoing strfuncti changes caused by behavioural interventions is paramount in evaluating the effectiveness of such practices. Here, using a systematic review approach, we identified 25 peer-reviewed magnetic resonance imaging (MRI) studies demonstrating grey matter changes related to mindfulness meditation. An activation likelihood estimation (ALE) analysis (n = 16) revealed the right anterior ventral insula as the only significant region with consistent effect across studies, whilst an additional functional connectivity analysis indicates that both left and right insulae, and the anterior cingulate gyrus with adjacent paracingulate gyri should also be considered in future studies. Statistical meta-analyses suggest medium to strong effect sizes from Cohen’s d ~ 0.8 in the right insula to ~ 1 using maxima across the whole brain. The systematic review revealed design issues with selection, information, attrition and confirmation biases, in addition to weak statistical power. In conclusion, our analyses show that mindfulness meditation practice does induce grey matter changes but also that improvements in methodology are needed to establish mindfulness as a therapeutic intervention.

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Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Mindfulness related changes in grey matter: a systematic review and meta‐analysis

Pernet

Белов

Delorme

et al. 2021

Brain Imaging and Behavior

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“…Four studies in our review also reported left insular changes (Engen et al, 2018; Fahmy et al, 2018, Grant et al, 2010, Luders et al, 2015) but they were spatially too dispersed to show significant ALE overlap (figure2). Similarly, about 1/3 of studies (Chetelat et al (2017), Engen et al, (2018), Fahmy et al, (2018), Grant et al, (2010), Grant et al, (2013), Kurth et al, (2014), Lu et al, (2014)) showed activations over the (broadly speaking) anterior cingulate/paracingulate cortices, without enough spatially consistency to be a significant region in the ALE analysis, but coordinates overlap with the functional connectivity maps. Given that this region has also been linked to meditation in other reviews (see Boccia et al, 2015) we therefore recommend to also considered it as a-priori region of interest in future studies.…”

Section: Discussionmentioning

confidence: 65%

“…The ALE meta-analysis reveals a significant cluster over the right anterior insula, going over the extreme capsule to the claustrum, an overlap from ROI from Fahmy et al (2018 - opioid patients meditators > opioid patients control in the claustrum), Hernández et al (2016 - mediators > controls in the short insula gyrus) and Murakami et al (2012 - correlation with mindfulness in the short insula gyrus), a sub-region typically associated with emotion (Kurth et al, 2010). Lazar and colleagues (2005) were the first to observe important structural changes associated with sustained meditation practice in this region (although not included in the ALE analysis because no coordinates were reported in the article), but also the auditory, somato-sensorial and prefrontal cortices.…”

Section: Discussionmentioning

confidence: 99%

Mindfulness related changes in grey matter: A Systematic Review and Meta-analysis

Pernet

Below

Delorme

et al. 2020

Preprint

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Knowing target regions undergoing structural changes caused by behavioural interventions is paramount in evaluating the effectiveness of such practices. Here, using a systematic review approach, we identified 25 peer-reviewed magnetic resonance imaging (MRI) studies demonstrating grey matter changes related to mindfulness meditation. The activation likelihood estimation (ALE) analysis (n=16) revealed the right anterior ventral insula as the only significant region with consistent effect across studies, whilst an additional functional connectivity analysis indicates that both left and right insulae, inferior post-central gyri and the anterior cingulate gyrus with adjacent paracingulate gyri should also be considered in future studies. Statistical meta-analyses suggest medium to strong effect sizes from Cohen's d ~0.7 in the right insula to ~1 using maxima across the whole brain. The systematic review revealed design issues with selection, information, attrition and confirmation biases, in addition to weak statistical power. In conclusion, our analyses show that mindfulness meditation practice does induce grey matter changes but also that improvements in methodology are needed to establish mindfulness as a therapeutic intervention.

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“…Additional studies are warranted to replicate and extend these findings beyond naltrexone to buprenorphine and various therapy interventions. With respect to sMRI findings, OUD users completing 4 weeks of mindfulness-based treatment display improved striatum-INS and frontocingulate structural network strength than OUD users who received treatment as usual (136).…”

Section: Framing Oud Research Within the Neurocircuitry Of Addictionmentioning

confidence: 99%

Forging Neuroimaging Targets for Recovery in Opioid Use Disorder

et al. 2019

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The United States is in the midst of an opioid epidemic and lacks a range of successful interventions to reduce this public health burden. Many individuals with opioid use disorder (OUD) consume drugs to relieve physical and/or emotional pain, a pattern that may increasingly result in death. The field of addiction research lacks a comprehensive understanding of physiological and neural mechanisms instantiating this cycle of Negative Reinforcement in OUD, resulting in limited interventions that successfully promote abstinence and recovery. Given the urgency of the opioid crisis, the present review highlights faulty brain circuitry and processes associated with OUD within the context of the Three-Stage Model of Addiction (1). This model underscores Negative Reinforcement processes as crucial to the maintenance and exacerbation of chronic substance use together with Binge/Intoxication and Preoccupation/Anticipation processes. This review focuses on cross-sectional as well as longitudinal studies of relapse and treatment outcome that employ magnetic resonance imaging (MRI), functional near-infrared spectroscopy (fNIRs), brain stimulation methods, and/or electroencephalography (EEG) explored in frequency and time domains (the latter measured by event-related potentials, or ERPs). We discuss strengths and limitations of this neuroimaging work with respect to study design and individual differences that may influence interpretation of findings (e.g., opioid use chronicity/recency, comorbid symptoms, and biological sex). Lastly, we translate gaps in the OUD literature, particularly with respect to Negative Reinforcement processes, into future research directions involving operant and classical conditioning involving aversion/stress. Overall, opioid-related stimuli may lessen their hold on frontocingulate mechanisms implicated in Preoccupation/Anticipation as a function of prolonged abstinence and that degree of frontocingulate impairment may predict treatment outcome. In addition, longitudinal studies suggest that brain stimulation/drug treatments and prolonged abstinence can change brain responses during Negative Reinforcement and Preoccupation/Anticipation to reduce salience of drug cues, which may attenuate further craving and relapse. Incorporating this neuroscience-derived knowledge with the Three-Stage Model of Addiction may offer a useful plan for delineating specific neurobiological targets for OUD treatment.

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Mindfulness-based interventions modulate structural network strength in patients with opioid dependence

Cited by 17 publications

References 56 publications

Mindfulness related changes in grey matter: a systematic review and meta‐analysis

Mindfulness related changes in grey matter: a systematic review and meta‐analysis

Mindfulness related changes in grey matter: A Systematic Review and Meta-analysis

Forging Neuroimaging Targets for Recovery in Opioid Use Disorder

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