Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up

Abstract

This article presents a study protocol for a single-blind randomized controlled trial to test the efficacy and feasibility of mindfulness-based cognitive therapy. A total of 120 un-medicated Chinese obsessive-compulsive disorder patients will be randomized to the mindfulness-based cognitive therapy group, the selective serotonin reuptake inhibitor group or the psycho-education group for 11 sessions in 10 weeks. A range of scales for clinical symptoms and functional magnetic resonance imaging will be completed at baseline (week 0), mid-intervention (week 4), post-intervention (week 10) and the 6-month follow-up (weeks 14, 22 and 34). The study will have relevance to decisions about treatment options for un-medicated obsessive-compulsive disorder patients.

Mindfulness-Based Cognitive Therapy for Unmedicated Obsessive-Compulsive Disorder: A Randomized Controlled Trial With 6-Month Follow-Up

“…As shown in Figure 1 , this was an single-blind, randomized, actively controlled clinical trial with three study arms: SSRI group; MBCT group; and PE group ( 26 ). Eligible unmedicated OCD participants, including those without a medication history of psychiatric drugs, or have been discontinued for more than 8 weeks were recruited from 7th June, 2017 to 30th July, 2018.…”

“…The focus of Session 10 is learning to take constructive risks in a mindful way. Session 11 is a 1-day mindfulness retreat, aimed at reviewing previous practices and enhancing motivation to continuing the practices ( 26 ). During each session, participants received handouts to facilitate comprehension.…”

“…The theme of Sessions 9 and 10 is the prevention and relapse of OCD. And Session 11 is to discuss plans for the future and the support of each other ( 26 ).…”

Mindfulness-based and acceptance-based programmes in the treatment of obsessive–compulsive disorder: a study protocol for a systematic review and meta-analysis

“…Further RCTs are also expected to be available soon. 46 Previous reviews hint at the usefulness of MABPs for people with OCD. 15 16 47 48 However, a systematic review of all available evidence including a metaanalysis on the effectiveness of MABPs in the treatment of OCD is still lacking.…”

“…In recent years, a growing number of RCTs33–40 and non-randomised trials (NRTs)16 25 41–45 on the effectiveness of MABPs for patients diagnosed with OCD have been published. Further RCTs are also expected to be available soon 46. Previous reviews hint at the usefulness of MABPs for people with OCD 15 16 47 48.…”