Mindfulness based cognitive therapy for youth with inflammatory bowel disease and depression - Findings from a pilot randomised controlled trial

Ewais, Tatjana; Kenny, Maura; Hay, Karen; Houldin, Evan; Chuang, Kai-Hisang; Tefay, Merilyn; Kisely, Steve

doi:10.1016/j.jpsychores.2021.110594

Cited by 19 publications

(17 citation statements)

References 58 publications

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“…Mindfulness-based interventions (MBIs), which primarily manifest as attention to one's physical sensations, thoughts, and emotions, have also been shown to have a positive impact on relieving stress levels and improving QoL in IBD patients (193)(194)(195)(196). For example, patients with inactive UC demonstrated significantly lower stress and higher QoL after mindfulnessbased stress reduction treatment (197).…”

Section: Psychotherapy and Antidepressants For Patients With Ibdmentioning

confidence: 99%

“…Particularly, CD patients with severe baseline psychological symptoms were the greatest beneficiaries of MBIs ( 198 ). Additionally, some studies have indicated that MBIs likely represented a promising intervention to reduce inflammation in IBD patients because MBIs could effectively decrease the levels of mucosal inflammatory biomarkers, including IL-6, fecal calprotectin, and CRP levels ( 194 , 196 , 198 ). Thus far, limited support is available for the effects of MBI on disease-related and physiologic outcomes.…”

Section: Psychotherapy and Antidepressants For Patients With Ibdmentioning

confidence: 99%

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Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Liu²,

Li³

et al. 2022

Front. Immunol.

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Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn’s disease (CD), is an autoimmune gastrointestinal disease characterized by chronic inflammation and frequent recurrence. Accumulating evidence has confirmed that chronic psychological stress is considered to trigger IBD deterioration and relapse. Moreover, studies have demonstrated that patients with IBD have a higher risk of developing symptoms of anxiety and depression than healthy individuals. However, the underlying mechanism of the link between psychological stress and IBD remains poorly understood. This review used a psychoneuroimmunology perspective to assess possible neuro-visceral integration, immune modulation, and crucial intestinal microbiome changes in IBD. Furthermore, the bidirectionality of the brain–gut axis was emphasized in the context, indicating that IBD pathophysiology increases the inflammatory response in the central nervous system and further contributes to anxiety- and depression-like behavioral comorbidities. This information will help accurately characterize the link between psychological stress and IBD disease activity. Additionally, the clinical application of functional brain imaging, microbiota-targeted treatment, psychotherapy and antidepressants should be considered during the treatment and diagnosis of IBD with behavioral comorbidities. This review elucidates the significance of more high-quality research combined with large clinical sample sizes and multiple diagnostic methods and psychotherapy, which may help to achieve personalized therapeutic strategies for IBD patients based on stress relief.

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Section: Psychotherapy and Antidepressants For Patients With Ibdmentioning

confidence: 99%

Section: Psychotherapy and Antidepressants For Patients With Ibdmentioning

confidence: 99%

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Liu²,

Li³

et al. 2022

Front. Immunol.

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“…After being diagnosed, HCPs are one of the most frequently used sources of support for AYAs [ 38 ]. A recent HCP-administered mindfulness intervention improved depression in AYAs with IBD [ 39 ]. These findings support the value of HCP-led interventions to promote PTG in AYAs.…”

Section: Discussionmentioning

confidence: 99%

Nirvana: A Qualitative Study of Posttraumatic Growth in Adolescents and Young Adults with Inflammatory Bowel Disease

Zhu²,

Liu³

et al. 2022

Children

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(1) Background: Psychosomatic discomfort is prevalent among adolescents and young adults (AYAs) with inflammatory bowel disease (IBD). Post-traumatic growth (PTG) has been a protective factor in earlier research. However, little is known regarding PTG among AYAs with IBD. This study investigates the generation of PTG in adolescents and young adults with inflammatory bowel disease (IBD) and finds positive coping skills employed in clinical nursing practice. (2) Methods: In 2021, 32 individuals were interviewed utilizing a semi-structured interview guide. This study used qualitative content analysis. (3) Results: The interviews revealed five themes: spiritual change, internalized supportiveness, cognitive re-shaping, externalized behaviors, and future-oriented thinking. (4) Conclusions: The research revealed the presence of PTG in AYAs with IBD. To give tailored care to patients, medical professionals must monitor the state of their PTG development in a planned and focused manner.

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“…However, the variety in MBIs was rather high, none of the studies had psychological distress as primary outcome, and most studies suffered from methodological limitations such as small sample size, incomplete data reporting and a lack of delity MBCT compared to the waitlist control condition (19). Two additional RCTs examining MBCT in IBD were conducted after the meta-analysis (20,21). Ewais et al showed that depressed young adults with IBD were less depressed and stressed after MBCT, with an improvement in coping but not in QoL (20).…”

mentioning

confidence: 99%

“…Two additional RCTs examining MBCT in IBD were conducted after the meta-analysis (20,21). Ewais et al showed that depressed young adults with IBD were less depressed and stressed after MBCT, with an improvement in coping but not in QoL (20). Finally, in a recent study of Bredero et al, fatigued IBD patients experienced signi cantly lower levels of fatigue after MBCT compared to the waiting-list group (21).…”

mentioning

confidence: 99%

Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease: study protocol for a multicentre randomised controlled trial (MindIBD)

Avest

Velthoven

Speckens

et al. 2023

Preprint

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Background Many patients with Inflammatory Bowel Diseases (IBD) suffer from psychological distress, fatigue and sleep disturbances, which are associated with reduced quality of life (QoL) and increased societal costs. Only limited psychosocial treatment options are available. As Mindfulness Based Cognitive Therapy (MBCT) has demonstrated to improve psychological distress, QoL and sleep in other populations, MBCT might also be effective in patients with IBD. Methods The MindIBD study is a prospective, multicentre, randomised controlled trial comparing MBCT plus Treatment As Usual (TAU) versus TAU alone in a targeted number of 136 IBD patients in remission, aged 16 years and older with at least mild psychological distress (Hospital Anxiety and Depression Scale (HADS) total score ≥ 11). Primary outcome is reduction of psychological distress post-intervention, measured by the HADS. In addition, the effect of MBCT on sleep quality (including actigraphy and electroencephalography recordings), fatigue, disease activity, perceived disease control, QoL and positive mental health will be examined. Assessments will be conducted at baseline and at 3, 6, 9 and 12 months follow-up. Cost-effectiveness will be determined and a process evaluation will be conducted. Discussion This study will provide valuable insight into the clinical effect of MBCT on psychological distress, sleep quality, fatigue and QoL in IBD patients and into the cost-effectiveness. If effective, MBCT can be a valuable addition to the available psychosocial interventions for patients with IBD. Moreover, findings from this study may also be applicable in patients with other chronic conditions. Trial registration: ClinicalTrials.gov: NCT04646785, registered on 30/11/2020.

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Mindfulness based cognitive therapy for youth with inflammatory bowel disease and depression - Findings from a pilot randomised controlled trial

Cited by 19 publications

References 58 publications

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Nirvana: A Qualitative Study of Posttraumatic Growth in Adolescents and Young Adults with Inflammatory Bowel Disease

Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease: study protocol for a multicentre randomised controlled trial (MindIBD)

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