Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study

Lent, Debora Melo van; O’Donnell, Adrienne; Beiser, Alexa S.; Vasan, Ramachandran S.; DeCarli, Charles; Scarmeas, Nikolaos; Wagner, Michael; Jacques, Paul F.; Seshadri, Sudha; Himali, Jayandra J.; Pase, Matthew P.

doi:10.3233/jad-201238

Cited by 33 publications

(31 citation statements)

References 40 publications

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“…The Global Cognitive Score has been used in other studies. 26 , 27 It is derived from a principal component analysis forcing a single score solution. The score combines weighted loadings for Trail‐Making Test Part B, Hooper Visual Organization Test, Logical Memory, Visual Reproduction, Paired Associate Learning, and Similarities (Data S1 ).…”

Section: Methodsmentioning

confidence: 99%

Relations of Metabolic Health and Obesity to Brain Aging in Young to Middle‐Aged Adults

Angoff

Himali

Maillard

et al. 2022

JAHA

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Background We aimed to evaluate the association between metabolic health and obesity and brain health measured via magnetic resonance imaging and neurocognitive testing in community dwelling adults. Methods and Results Framingham Heart Study Third Generation Cohort members (n=2170, 46±9 years of age, 54% women) without prevalent diabetes, stroke, dementia, or other neurologic conditions were grouped by metabolic unhealthiness (≥2 criteria for metabolic syndrome) and obesity (body mass index ≥30 kg/m 2 ): metabolically healthy (MH) nonobese, MH obese, metabolically unhealthy (MU) nonobese, and MU obese. We evaluated the relationships of these groups with brain structure (magnetic resonance imaging) and function (neurocognitive tests). In multivariable‐adjusted analyses, metabolically unhealthy individuals (MU nonobese and MU obese) had lower total cerebral brain volume compared with the MH nonobese referent group (both P <0.05). Additionally, the MU obese group had greater white matter hyperintensity volume ( P =0.004), whereas no association was noted between white matter hyperintensity volume and either groups of metabolic health or obesity alone. Obese individuals had less favorable cognitive scores: MH obese had lower scores on global cognition, Logical Memory‐Delayed Recall and Similarities tests, and MU obese had lower scores on Similarities and Visual Reproductions‐Delayed tests (all P ≤0.04). MU and obese groups had higher free water content and lower fractional anisotropy in several brain regions, consistent with loss of white matter integrity. Conclusions In this cross‐sectional cohort study of younger to middle‐aged adults, poor metabolic health and obesity were associated with structural and functional evidence of brain aging. Improvement in metabolic health and obesity may present opportunities to improve long‐term brain health.

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Section: Methodsmentioning

confidence: 99%

Relations of Metabolic Health and Obesity to Brain Aging in Young to Middle‐Aged Adults

Angoff

Himali

Maillard

et al. 2022

JAHA

Self Cite

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“…Since 2015, MIND has been derived in other populations, often with modifications to account for diet assessment tools and differences in dietary behaviors. To our knowledge, seventeen population studies based in the US, Sweden, France, Australia, Spain, Netherlands, Brazil and Israel have investigated the relationship between MIND and cognitive health [ 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Five studies examined cognitive abilities [ 4 , 5 , 6 , 7 , 8 ]; four reported better cognitive performance with greater MIND adherence [ 4 , 5 , 6 , 7 ], while the fifth reported a cross-over interaction with income level [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank

et al. 2022

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A high adherence to the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) has been associated with better cognition and a lower risk of dementia in some but not all studies. We measured adherence to MIND and its association with cognitive health in the UK Biobank (UKB). A MIND score was derived from 24 h diet recall questionnaires for 120,661 participants who completed at least one of seven self-administered cognitive function tests. In a subset of 78,663 participants aged 55+, diagnosis of dementia was determined by linked hospital and death records. Multivariable regression and Cox proportional hazard ratio (HR) models were used to examine associations of MIND with cognitive ability and incident dementia. Higher adherence to MIND was associated with a small but significant worsening in performance on five of seven cognitive tests (p < 0.002). Associations were strongest among highly educated participants (p < 0.002 for MIND×education interaction). After a mean follow-up time of 10.5 years, 842 participants developed dementia. Overall, MIND adherence was not associated with incident dementia. An inverse association was observed among females (HR = 0.87 per score standard deviation (SD), p = 0.008) but not males (HR = 1.09, p = 0.11) (p = 0.008 for MIND×sex interaction). Similar associations with cognitive ability and dementia were observed for the Alternative Healthy Eating Index-2010 (AHEI-2010) dietary pattern. Associations were not modified by genetic susceptibility. In UKB, the MIND diet was not associated with better cognitive test scores and only with lower dementia risk in women.

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“…Gendreau et al reported that the glycemic load in the afternoon (mostly representing afternoon snacks) had a synergic effect with ε4 to elevate AD risk [ 99 ]. In another recent report, both Mediterranean and MIND diet patterns are more beneficial to ε4 carriers, as was found by Debora et al when examining the association between MIND diet score and cognitive assessment in the Framingham Heart Study [ 100 ].…”

Section: Diet and Apoementioning

confidence: 90%

Factors Influencing Alzheimer’s Disease Risk: Whether and How They are Related to the APOE Genotype

Zhang

et al. 2022

Neurosci. Bull.

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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease featuring progressive cognitive impairment. Although the etiology of late-onset AD remains unclear, the close association of AD with apolipoprotein E (APOE), a gene that mainly regulates lipid metabolism, has been firmly established and may shed light on the exploration of AD pathogenesis and therapy. However, various confounding factors interfere with the APOE-related AD risk, raising questions about our comprehension of the clinical findings concerning APOE. In this review, we summarize the most debated factors interacting with the APOE genotype and AD pathogenesis, depict the extent to which these factors relate to APOE-dependent AD risk, and discuss the possible underlying mechanisms.

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Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study

Cited by 33 publications

References 40 publications

Relations of Metabolic Health and Obesity to Brain Aging in Young to Middle‐Aged Adults

Relations of Metabolic Health and Obesity to Brain Aging in Young to Middle‐Aged Adults

MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank

Factors Influencing Alzheimer’s Disease Risk: Whether and How They are Related to the APOE Genotype

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