Mind-Body Medicine

Bilkis, Michael R.; Mark, Kenneth A.

doi:10.1001/archderm.134.11.1437

Cited by 22 publications

(4 citation statements)

References 5 publications

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“…The discovery of such concrete pathways of neuroimmunomodulation is in agreement with the observation that mental stress seems to alter immune response (19). More intriguing is the observation that pure intrapsychic events, induced by hypnosis, as well as psychological stress, modulate delayed-type hypersensitivity responses type I and IV, UVB radiation-induced erythema and skin blood flow, cellular immune function, and monocyte chemotactic activity in sera (16,(20)(21)(22)(23). In particular, the flare reaction, but not wheal formation, after a histamine prick test, was significantly decreased in patients that underwent direct suggestion during hypnosis compared to controls (24).…”

Section: Brain-body Influencessupporting

confidence: 65%

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The neuro-immuno-cutaneous-endocrine network: relationship between mind and skin

et al. 2003

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Brain-body(skin) influences are bi-directional and skin should be considered as an active neuro-immuno-endocrine interface, where effector molecules act as common words used in a dynamic dialogue between brain, immune-system and skin. It has been widely demonstrated that stimuli received in the skin can influence the immune, endocrine and nervous systems at both a local and central level. However, the brain can also modulate inflammatory conditions locally induced in the skin. It has been experimentally demonstrated that intracerebral administration of the tridecapeptide alpha-MSH or even its COOH-terminal tripeptide can in fact inhibit cutaneous inflammation induced by the application of topical irritants and intradermal injection of cytokines. The skin can therefore alter the pharmacology of the CNS by releasing large amounts of NPs which obviously do work locally in the skin and beyond the skin. Alpha-MSH may represent a key molecule for understanding this aspect of cutaneous-immune-neuro-endocrine-mental biological communication, being it is also generated in the skin. This molecule may in the future be used as a potent anti-inflammatory agent in clinical dermatology, and preclinical trials are presently in progress.

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Section: Brain-body Influencessupporting

confidence: 65%

“…There is increasing evidence that hypnosis can be used to modulate immunologic and cutaneous inflammatory parameters, but more studies are needed to understand the precise biologic mechanisms that link brain and skin so that new tools for the dermatologist can be developed (22,23).…”

Section: Brain-body Influencesmentioning

confidence: 99%

The neuro-immuno-cutaneous-endocrine network: relationship between mind and skin

et al. 2003

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“…The discovery of such concrete pathways of neuroimmunomodulation is in agreement with the observation that mental stress seems to alter immune response 7 . More intriguing is the observation that pure intrapsychic events induced by hypnosis, as well as psychologic stress, modulate delayed‐type hypersensitivity responses, UVB radiation‐induced erythema and skin blood flow, cellular immune function, flare reaction of the cutaneous histamine prick test, and monocyte chemotactic activity in sera 4,8–11 …”

Section: Brain‐body Influences: From Brain To Bodysupporting

confidence: 60%

“…Increasing evidence that hypnosis can be used to modulate immunologic and cutaneous inflammatory parameters, for example, leads to new understanding of the precise biologic mechanisms in the link between body and brain to the development of new tools for the dermatologists 10,11 …”

Section: Brain‐body Influences: From Brain To Bodymentioning

confidence: 99%

Can the brain inhibit inflammation generated in the skin? The lesson of α‐melanocyte‐stimulating hormone

et al. 2002

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The neuro-immuno-cutaneous-endocrine network is not a simple construct featuring organ systems intimately involved in the bridge between body and mind. Mind-body influences are bi-directional and the skin should be considered an active neuroimmunoendocrine interface, where effector molecules of neuropeptides act as common words used in a dynamic dialogue between brain, immune system and skin. Gamma-melanocyte stimulating hormone (gamma-MSH), one of the principal neuroimmunomodulating peptides, seems to exercise some control on the cutaneous inflammatory process, through a central action mediated by descending anti-inflammatory neural pathways and via local direct influence on inflammatory cells infiltrating the dermis, such as monocytes, macrophages and neutrophils. Gamma-MSH down-regulates the production of proinflammatory cytokines, while the production of the anti-inflammatory cytokine IL-10 is stimulated by gamma-MSH. Finally, gamma-MSH seems to regulate the expression of surface molecules in immunocompetent cells. Thus, further studies may lead to the use of gamma-MSH as an important anti-inflammatory agent in clinical dermatology.

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Psychological Stress Perturbs Epidermal Permeability Barrier Homeostasis

Garg

Chren²,

Sands³

et al. 2001

Arch Dermatol

328

106

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Background: A large number of skin diseases, including atopic dermatitis and psoriasis, appear to be precipitated or exacerbated by psychological stress. Nevertheless, the specific pathogenic role of psychological stress remains unknown. In 3 different murine models of psychological stress, it was recently shown that psychological stress negatively impacts cutaneous permeability barrier function and that coadministration of tranquilizers blocks this stressinduced deterioration in barrier function. Objectives and Methods: The relationship between psychological stress and epidermal permeability barrier function was investigated in 27 medical, dental, and pharmacy students without coexistent skin disease. Their psychological state was assessed with 2 well-validated measures: the Perceived Stress Scale and the Profile of Mood States. Barrier function was assessed simultaneously with the stress measures at periods of presumed higher stress (during final examinations) and at 2 assumed, lower stress occasions (after return from winter vacation [approximately 4 weeks before final examinations] and during spring vacation [approximately 4 weeks after final examinations]). Results: The subjects as a group demonstrated a decline in permeability barrier recovery kinetics after barrier disruption by cellophane tape stripping, in parallel with an increase in perceived psychological stress during the higher vs the initial lower stress occasions. During the follow-up, presumed lower stress period, the subjects again displayed lower perceived psychological stress scores and improved permeability barrier recovery kinetics, comparable to those during the initial lower stress period. Moreover, the greatest deterioration in barrier function occurred in those subjects who demonstrated the largest increases in perceived psychological stress. Conclusion: These studies provide the first link between psychological status and cutaneous function in humans and suggest a new pathophysiological paradigm, ie, stress-induced derangements in epidermal function as precipitators of inflammatory dermatoses.

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Mind-Body Medicine

Cited by 22 publications

References 5 publications

The neuro-immuno-cutaneous-endocrine network: relationship between mind and skin

The neuro-immuno-cutaneous-endocrine network: relationship between mind and skin

Can the brain inhibit inflammation generated in the skin? The lesson of α‐melanocyte‐stimulating hormone

Psychological Stress Perturbs Epidermal Permeability Barrier Homeostasis

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