Mimosine Content of Leucaena leucocephala and the Sensitivity of Rhizobium to Mimosine

Mathews, Anne; Vittal, P.

doi:10.1016/s0176-1617(85)80074-2

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…The levels of mimosine content in LL depends on many factors such as locations, ages of plant, soil types, seasons, and extraction methods (Ghosh & Bandyopadhyay, 2007). Mimosine level extracted from LL grown in India was 3.33 % dry weight (Mathews & Vittal Rai, 1985) whereas of plant grown in Australia was 45 g/kg (or 4.5 %) dry weight (Tangendjaja et al, 1986). Additionally, the mimosine level in LL fresh leaves harvested in Malaysia examined by using High Performance Liquid Chromatography was 1.6 % wet weight (Zayed et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Kanla¹,

Burawat²,

Arun³

et al. 2018

Int. J. Morphol.

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KANLA, P.; BURAWAT, J.; ARUN, S.; SAWATPANICH, T.; CHAICHUN, A. & IAMSAARD, S. Acute effects of mimosine purified from Leucaena leucocephala on male reproductive system of adult mice. Int. J. Morphol., 36(2):507-512, 2018. SUMMARY. This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 mg/KgBW, respectively for 7 consecutive days. The morphological features and weights of body and reproductive organs including testis, epididymis plus vas deferens, and seminal vesicle were compared among groups. In addition, epididymal sperm concentration and the changes of histopathology of testicular tissues in all groups were observed. The results showed that mimosine in all doses did not affect mice body weights. However, all doses of mimosine could significantly reduce the absolute and relative weights of testis and seminal vesicle but not of epididymis plus vas deferens. Significantly, mimosine at doses of 30, and 60 mg/KgBw could decrease sperm concentration. Moreover, the seminiferous atrophy and degeneration were obviously found in mimosine treated mice as compared to the control. In conclusion, consumption of Leucaena leucocephala edible parts containing mimosine could damage male reproductive organs which may cause acute male subfertility or infertility. KANLA, P.; BURAWAT, J.; ARUN, S.; SAWATPANICH, T.; CHAICHUN, A. & IAMSAARD, S. Acute effects of mimosine purified from Leucaena leucocephala on male reproductive system of adult mice. Int. J. Morphol., 36(2):507-512, 2018.

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Section: Discussionmentioning

confidence: 99%

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Kanla¹,

Burawat²,

Arun³

et al. 2018

Int. J. Morphol.

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“…Leucaena contains mimosine in all parts of the plants, 4-10 % in the shoots (Jones, 1979), 1-1?5 % in the roots (Mathews & Rai, 1985) and approximately 0?5 % in the nodules (Soedarjo & Borthakur, 1998). Mimosine is toxic to animals, and therefore farm animals grazing on leucaena foliage often suffer from physiological disorders such as thyroid enlargement and loss of hair (Jones, 1979).…”

Section: Introductionmentioning

confidence: 99%

The mid genes of Rhizobium sp. strain TAL1145 are required for degradation of mimosine into 3-hydroxy-4-pyridone and are inducible by mimosine

et al. 2003

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Mimosine is a toxin present in the tree-legume leucaena (Leucaena leucocephala), including its root nodules and the root exudates. The leucaena-nodulating Rhizobium sp. strain TAL1145 degrades mimosine (Mid + ) and utilizes it as a source of carbon and nitrogen. Twelve TAL1145 mutants defective in mimosine degradation (Mid 2 ) were made through Tn3Hogus, TnphoA or kanamycinresistance-cassette insertions. A 5?0 kb PstI fragment of TAL1145, subcloned from a cosmid clone containing mid genes for mimosine degradation, complemented most of the Mid 2 mutants.Sequencing this fragment and the adjacent 0?9 kb PstI fragment identified five genes, midA, midB, midC, midD and midR, of which the first three genes encode ABC transporter proteins involved in mimosine uptake, while midD encodes an aminotransferase required for degrading mimosine into 3-hydroxy-4-pyridone, and midR is a regulatory gene encoding a LysR-type transcriptional activator. The location of MidA in the periplasm was shown by making two midA : : phoA fusions, which made active alkaline phosphatase in the periplasm. The various mid : : gus and midA : : phoA fusions were inducible by mimosine, and a midD : : gus fusion mutant showed b-glucuronidase activity in the leucaena nodules, indicating that midD is expressed in the nodules. Similarly, a midA : : phoA fusion expressed alkaline phosphatase activity in the leucaena nodules, indicating that mimosine induces midA transcription in the bacteroids. mid genes are specific for the Mid + strains of leucaena Rhizobium and are absent in strains of other Rhizobium, Sinorhizobium and Bradyrhizobium spp.

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Mimosine, a toxin produced by the tree-legume leucaena provides a nodulation competition advantage to mimosine-degrading rhizobium strains

Soedarjo

Borthakur

1998

Soil Biology and Biochemistry

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Mimosine Content of Leucaena leucocephala and the Sensitivity of Rhizobium to Mimosine

Cited by 5 publications

References 7 publications

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

The mid genes of Rhizobium sp. strain TAL1145 are required for degradation of mimosine into 3-hydroxy-4-pyridone and are inducible by mimosine

Mimosine, a toxin produced by the tree-legume leucaena provides a nodulation competition advantage to mimosine-degrading rhizobium strains

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