Mimicking Drug-Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes

Abstract

Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)‐MnO2 nanoparticle‐based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA‐MnO2 nanoparticles possess sub‐10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications.

Intelligent Nanocomposites with Intrinsic Blood–Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

“…As shown in Scheme a, MnO 2 nanocrystals are grown in situ into the holo‐Tf through a mild biomineralization method wherein the solution pH must be finely regulated. Unlike traditional approaches to developing manganese oxide on proteins under strongly basic or oxidizing conditions, which inevitably damage the protein structure, the method adopted here preserves the structure of holo‐Tf and thus ensures its targeting ability. Protoporphyrin (ppIX), a sonosensitizer, is further introduced into the holo‐Tf to obtain MnO 2 @Tf‐ppIX nanoparticles (denoted TMPs).…”

O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia

“…First, HSA-MnO 2 NPs were obtained via the reduction of KMnO 4 with HSA. 50 Next, the carboxylic groups of Ce6 were conjugated with the amine groups of the lysine residues within HSA to form HSA-MnO 2 -Ce6 NPs. 53 The molar ratio of Ce6 to MnO 2 in HSA-MnO 2 -Ce6 NPs was 0.084:1.…”

“…HSA-coated MnO 2 NPs (HSA-MnO 2 NPs) were prepared as follows. 50 In brief, 6.32 mg KMnO 4 dispersed in 0.6 mL water was drop-wise added into 50 mg HSA dispersed in 1.4 mL PBS. The mixture was stirred at 37 °C for 2 h to obtain HSA-MnO 2 NPs.…”

Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

“…− is rapidly reduced to MnO 2 accompanied by the release of ROS that can kill bacteria [60], we put forward a novel biosynthetic strategy to construct a TME-responsive MnO x -based nanoplatform for cancer theranostics (Figure 1). Specifically, Escherichia coli (E. coli) bacterial cells are directly used as both the template and the reducing agent to react with the KMnO 4 aqueous solution via ultrasonication at room temperature.…”