MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription

Callahan, Christopher A.; Ofstad, Tyler; Horng, Lily; Wang, Jordon K.; Zhen, Hanson H.; Oro, Anthony E.

doi:10.1101/gad.1221804

Cited by 140 publications

(145 citation statements)

References 37 publications

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“…MTSS1, whose expression is down-regulated or absent in several metastatic cell lines (Nixdorf et al 2004, Loberg et al 2005, is a sonic hedgehog responsive actin binding protein involved in the regulation of actin filament assembly and is a potentiator of Gli-dependent transcription (Callahan et al 2004). Interestingly, MTSS1 was transiently up-regulated in the granulosa layer of bovine follicles at 12 h post-GnRH injection.…”

Section: Discussionmentioning

confidence: 97%

“…CD36 is a multifunctional scavenger receptor that binds known autocrine growth factors that can regulate cell growth, adhesion, and angiogenesis (Febbraio et al 2001). MTSS1 is a sonic hedgehog responsive actin binding protein (Callahan et al 2004) and a functional hedgehog signaling system in murine follicles has been reported (Wijgerde et al 2005, Russell et al 2007. TFG is involved in promoting NF-kappaB activity (Miranda et al 2006), which is potentially related to cumulus expansion in mice (Takahashi et al 2006).…”

Section: Gonadotropin Surge Induced Up-regulation Of Gene Expression mentioning

confidence: 99%

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Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Jimenez-Krassel

Ireland

et al. 2009

Reproduction

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The molecular mechanisms of ovulation and luteinization have not been well established, partially due to lack of a comprehensive understanding of functionally significant genes up-regulated in response to an ovulatory stimulus and the signaling pathways involved. In the present study, transcripts increased in bovine preovulatory follicles following a GnRH-induced LH surge were identified using microarray technology. Increased expression of 368 and 878 genes was detected at 12 (368 genes) and 20 h (878 genes) following GnRH injection. The temporal, cell specific and prostanoid-dependent regulation of selected genes (ADAM10, DBI, CD36, MTSS1, TFG, and RABGAP1) identified from microarray studies and related genes (ADAM17 and AREG) of potential significance were also investigated. Expression of mRNA for DBI and CD36 was simultaneously up-regulated in theca and granulosa cells (GC) following the LH surge, whereas temporal regulation of ADAM10, MTSS1, TFG, and RABGAP1 was distinct in the two cell compartments and increased granulosa TFG and RABGAP1 mRNA were prostanoid dependent. AREG mRNA was increased in theca and GCs at 12 and 24 h following GnRH injection. ADAM17 mRNA was increased in theca, but reduced in GCs 24 h following GnRH injection. The increased ADAM17 and AREG mRNA were prostanoid dependent. ADAM10 and ADAM17 protein were increased specifically in the apex but not the base of preovulatory follicles and the increase in ADAM17 was prostanoid dependent. Results reveal novel information on the regulation of preovulatory gene expression and suggest a potential functional role for ADAM10 and ADAM17 proteins in the region of follicle rupture.

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Section: Discussionmentioning

confidence: 97%

Section: Gonadotropin Surge Induced Up-regulation Of Gene Expression mentioning

confidence: 99%

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Jimenez-Krassel

Ireland

et al. 2009

Reproduction

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“…Positive regulators of Gli function have also been found, including the kinase Dyrk1 [87] and the actin-binding protein Missing in metastasis (MIM, also called BEG4) [88]. Others include peptide-growth factor (PGF)-activating receptor tyrosine kinases, such as EGF, PDGF, FGF and IGF, which synergize with or affect Hh-Gli function [21,48,56,57,89].…”

Section: Box 2 the Gli Code Is Regulated Exquisitely By Multiple Mechmentioning

confidence: 99%

The Gli code: an information nexus regulating cell fate, stemness and cancer

Altaba

Mas

Stecca

2007

Trends in Cell Biology

343

361

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The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.

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“…K17 is a known target of Hh signaling (24), and expressing the constitutively active SmoM2 allele to activate Hh signaling in the epidermis causes K17 expression and epidermal thickening (25), recapitulating aspects of the touch dome microenvironment. To test if Hh activation is sufficient to drive Merkel cell production or expansion in the epidermis, we used adult K14-CreER;R26 SmoM2/+ mice (n = 8) to activate the Hh signaling pathway in epidermal keratinocytes.…”

Section: Activation Of Shh Signaling Is Not Sufficient To Establish Omentioning

confidence: 99%

Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium

Xiao

Thoresen

Williams

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The touch dome is a highly patterned mechanosensory structure in the epidermis composed of specialized keratinocytes in juxtaposition with innervated Merkel cells. The touch dome epithelium is maintained by tissue-specific stem cells, but the signals that regulate the touch dome are not known. We identify touch dome stem cells that are unique among epidermal cells in their activated Hedgehog signaling and ability to maintain the touch dome as a distinct lineage compartment. Skin denervation reveals that renewal of touch dome stem cells requires a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epidermis demonstrates that Shh is an essential niche factor that maintains touch dome stem cells. Up-regulation of Hedgehog signaling results in neoplastic expansion of touch dome keratinocytes but no Merkel cell neoplasia. These findings demonstrate that nerve-derived Shh is a critical regulator of lineage-specific stem cells that maintain specialized sensory compartments in the epidermis.

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MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription

Cited by 140 publications

References 37 publications

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

The Gli code: an information nexus regulating cell fate, stemness and cancer

Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium

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