A crucial element of the quest of curbing carbon dioxide emissions is deemed to rely on a biobased economy, which will rely on the development of financially sustainable biorefining systems enabling a full exploitation of lignocellulosic biomass (and its macrocomponents, i.e. cellulose, hemicellulose and lignin) for the co-production of biofuels and bioderived platform chemicals. In this work, a general modelling framework conceived to steer decision-making regarding the strategic design and systematic planning of advanced biorefining supply networks is presented. The design task is formulated as a mixed integer linear program (MILP) which accounts for the maximisation of the supply chain profit, considering multi-echelon, multi-period, multi-feedstock and multiproduct aspects as well as spatially explicit features. The applicability of the proposed model, along with the use of a bi-level decomposition approach, are demonstrated with a case study of lignocellulose-based biorefining production systems in the SouthWest of Hungary. Results show the effectiveness of the tool in the decision-making regarding the systematic design of advanced biorefining SC networks. An economic analysis