Millimeter waves: Acoustic and electromagnetic

Ziskin, Marvin C.

doi:10.1002/bem.21750

Cited by 30 publications

(26 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The involvement of the nervous system in biological responses to RF-EMF is an extensively studied field [5,6] and lately, the implication of the peripheral nervous system in response to MMW has been highlighted, especially concerning modulation of the pain sensation [7].…”

Section: Introductionmentioning

confidence: 99%

“…We also assessed the potential effect of MMW on neuronal differentiation by measuring the protein expression of β-III-tubulin, a specific marker of neuronal phenotype. To this end, cells were exposed to 60.4 GHz MMW at 10 mW/cm², which is a typical incident power density (IPD) for therapeutic applications [7], and two times above the ICNIRP exposure limit for workers exposed on a wide surface (above 20 cm²) [28].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of 60-GHz millimeter waves on neurite outgrowth in PC12 cells using high-content screening

Haas

Page

Sauleau

et al. 2016

Neuroscience Letters

View full text Add to dashboard Cite

Highlights: 60 GHz MMW do not impact neuronal tubulin expression during PC12 differentiation. Exposure at 10 mW/cm² induces a slight increase in neurite outgrowth due to the thermal effect. The thermal effect impacts all parameters of the neurite outgrowth. AbstractTechnologies for wireless telecommunication systems using millimeter waves (MMW) will be widely deployed in the near future. Forthcoming applications in this band, especially around 60 GHz, are mainly developed for high data-rate local and body-centric telecommunications. At those frequencies, electromagnetic radiations have a very shallow penetration into biological tissues, making skin keratinocytes, and free nerve endings of the upper dermis the main targets of MMW. Only a few studies assessed the impact of MMW on neuronal cells, and none of them investigated a possible effect on neuronal differentiation.We used a neuron-like cell line (PC12), which undergoes neuronal differentiation when treated with the neuronal growth factor (NGF). PC12 cells were exposed at 60.4 GHz for 24 h, at an incident power density averaged over the cell monolayer of 10 mW/cm². Using a large scale cell-by-cell analysis based on high-content screening microscopy approach, we assessed potential effects of MMW on PC12 neurite outgrowth and cytoskeleton protein expression. No differences were found in protein expression of the neuronal marker β3-Tubulin nor in internal expression control β-Tubulin. On the other hand, our data showed a slight increase, although insignificant, in neurite outgrowth, induced by MMW exposure.However, experimental controls demonstrated that this increase was related to heating.Abbreviations: MMW (millimeter waves), HC (heat control).

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of 60-GHz millimeter waves on neurite outgrowth in PC12 cells using high-content screening

Haas

Page

Sauleau

et al. 2016

Neuroscience Letters

View full text Add to dashboard Cite

show abstract

“…Specific absorption rate (SAR) was obtained by measuring the initial temperature rise rate dT/dt| t=0 in a blood sample upon MMW exposure [Ziskin, ]. Under our experimental conditions, the approximation of the heating rate for Δt → 0 was dT/dt = 2.4 ± 0.4 °C per min, as measured in 5 independent experiments.…”

Section: Methodsmentioning

confidence: 99%

“…However, the mechanisms by which local MMW administration is able to produce systemic whole‐body effects are not well understood. Two major mechanisms have been proposed: (1) stimulation of the nervous system and (2) stimulation of the immune system [Pakhomov et al, ; Sypniewska et al, ; Ziskin, ].…”

Section: Introductionmentioning

confidence: 99%

Extremely high‐frequency electromagnetic radiation enhances neutrophil response to particulate agonists

Vlasova

Mikhalchik²,

Gusev³

et al. 2017

Bioelectromagnetics

View full text Add to dashboard Cite

The growing use of extremely high-frequency electromagnetic radiation (EHF EMR) in information and communication technology and in biomedical applications has raised concerns regarding the potential biological impact of millimeter waves (MMWs). Here, we elucidated the effects of MMW radiation on neutrophil activation induced by opsonized zymosan or E. coli in whole blood ex vivo. After agonist addition to blood, two samples were prepared. A control sample was incubated at ambient conditions without any treatment, and a test sample was exposed to EHF EMR (32.9-39.6 GHz, 100 W/m ). We used methods that allowed us to assess the functional status of neutrophils immediately after exposure: oxidant production levels were measured by luminol-dependent chemiluminescence, and morphofunctional changes to neutrophils were observed in blood smears. Results revealed that the response of neutrophils to both agonists was intensified if blood was exposed to MMW radiation for 15 min. Neutrophils were intact in both the control and irradiated samples if no agonist was added to blood before incubation. Similarly, exposing suspensions of isolated neutrophils in plasma to MMW radiation enhanced cell response to both zymosan and E. coli. Heating blood samples was shown to be the primary mechanism underlying enhanced EHF EMR-induced oxidant production by neutrophils in response to particulate agonists. Bioelectromagnetics. 39:144-155, 2018. © 2017 Wiley Periodicals, Inc.

show abstract

“…In this connection, gas-discharge plasma technologies applied both in Russia and abroad are of great interest [1][2][3]. Such medical gas-discharge devices as quartz lamp (discharge of mercury vapors) [4] and apparatus for darsonvalization (silent corona discharge) [5] are widely being used in Russia. Biological effects of recently developed gas-discharge Brig devices (Sarov, Nizhny Novgorod region, Russia) and Pilimin (Moscow, Russia), based on radiation of plasma spark discharge, are being investigated [6][7][8][9].…”

Section: Analysis Of Cytotoxic Effect Of Medical Gas-discharge Devicesmentioning

confidence: 99%

Analysis of Cytotoxic Effects of Medical Gas-Discharge Devices

Astafyeva¹,

Иванова²

2017

Sovrem Tehnol Med

View full text Add to dashboard Cite

Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russian FederationThe aim of the investigation was to analyze cytotoxic effects of various gas-discharge technologies. Materials and Methods. The following gas-discharge devices were used in the work: Pilimin series IR-1, IR-10 and Brig -radiation of spark discharge plasma; DBK-9 low-pressure mercury lamp -ultraviolet radiation; Corona device for darsonvalization -silent electric corona discharge. The objects of investigation were erythrocytes of Wistar rats, and lymphoid cells of Pliss lymphosarcoma.Results. All examined gas-discharge devices were established to possess membranotoxic and cytotoxic effects. The total number of erythrocytes and lymphoid cells diminished, while the number of nonviable cells grew with the increase of exposure time. Erythrocyte membrane was least resistant to the radiation of the spark discharge plasma with 1,500 μs pulse duration and to ultraviolet radiation of the mercury lamp, whereas erythrocytes were less resistant to the radiation by the gas-discharge devices than lymphoid cells. Pliss lymphosarcoma cells appeared to be more sensitive to the action of spark discharge plasma and corona discharge with 1-10 μs pulse duration. Radiation of spark discharge plasma with 150 μs pulse duration exhibited equally membranotoxic and cytotoxic effect.Conclusion. The results of assessing cytotoxic effect of various gas-discharge devices help to determine the direction of investigations when mechanisms of action of gas-discharge technologies are explored, and to recommend, in particular, a more profound study of such parameter as pulse discharge duration.Key words: gas-discharge technologies; radiation of spark discharge plasma; ultraviolet radiation; Darsonval corona discharge.For contacts: Irina P. Ivanova, e-mail: ivanova.ip@mail.ru Analysis of Cytotoxic Effect of Medical Gas-Discharge DevicesThe increasing number of neoplastic and infectious processes resistant to traditional methods of treatment (radiotherapy, chemotherapy, antibiotic therapy) stipulate the search and development of novel effective methods of inhibiting proliferative activity of neoplastic and prokaryotic cells, which possess cytotoxic effect and do not cause pronounced toxic effect on the organism as a whole. In this connection, gas-discharge plasma technologies applied both in Russia and abroad are of great interest [1][2][3]. Such medical gas-discharge devices as quartz lamp (discharge of mercury vapors) [4] and apparatus for darsonvalization (silent corona discharge) [5] are widely being used in Russia. Biological effects of recently developed gas-discharge Brig devices (Sarov, Nizhny Novgorod region, Russia) and Pilimin (Moscow, Russia), based on radiation of plasma spark discharge, are being investigated [6][7][8][9].To assess the efficacy of cytotoxic effect of any physical or chemical factor, it is necessary to carry out a primary screening to evaluate the resistance of the membrane and the cell as a whole to the acti...

show abstract

Millimeter waves: Acoustic and electromagnetic

Cited by 30 publications

References 44 publications

Effects of 60-GHz millimeter waves on neurite outgrowth in PC12 cells using high-content screening

Effects of 60-GHz millimeter waves on neurite outgrowth in PC12 cells using high-content screening

Extremely high‐frequency electromagnetic radiation enhances neutrophil response to particulate agonists

Analysis of Cytotoxic Effects of Medical Gas-Discharge Devices

Contact Info

Product

Resources

About