Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial

Socha, Piotr; Grote, Veit; Gruszfeld, Dariusz; Janas, Roman; Demmelmair, Hans; Closa‐Monasterolo, Ricardo; Escribano, Joaquín; Scaglioni, Silvia; Verduci, Elvira; Dain, Elena; Langhendries, Jean‐Paul; Perrin, Emmanuel; Koletzko, Berthold

doi:10.3945/ajcn.110.000596

Cited by 188 publications

(128 citation statements)

References 62 publications

(68 reference statements)

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“…Accelerated postnatal weight gain can result from high intake of growth-enhancing nutrients such as protein in the infant diet. Available evidence suggests that higher protein intakes increase plasma and tissue levels of insulin-releasing amino acids and of insulin and insulinlike growth factor 1, and thereby increase weight gain and adipogenic activity (36,37) .…”

Section: Accelerated Postnatal Growth Hypothesismentioning

confidence: 99%

Early nutrition programming of long-term health

et al. 2012

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Increasing evidence from the EU Project EARNEST and many other investigators demonstrates that early nutrition and lifestyle have long-term effects on later health and the risk of common non-communicable diseases (known as 'developmental programming'). Because of the increasing public health importance and the transgenerational nature of the problem, obesity and associated disorders are the focus of the new EU funded project 'EarlyNutrition'. Currently, three key hypotheses have been defined: the fuel mediated 'in utero' hypothesis suggests that intrauterine exposure to an excess of fuels, most notably glucose, causes permanent changes of the fetus that lead to obesity in postnatal life; the accelerated postnatal weight gain hypothesis proposes an association between rapid weight gain in infancy and an increased risk of later obesity and adverse outcomes; and the mismatch hypothesis suggests that experiencing a developmental 'mismatch' between a sub-optimal perinatal and an obesogenic childhood environment is related to a particular predisposition to obesity and corresponding co-morbidities. Using existing cohort studies, ongoing and novel intervention studies and a basic science programme to investigate those key hypotheses, project EarlyNutrition will provide the scientific foundations for evidence-based recommendations for optimal nutrition considering long-term health outcomes, with a focus on obesity and related disorders. Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level of the relationships between early life nutritional status and the risk of later adiposity. This will help refine strategies for intervention in early life to prevent obesity.Early nutrition: Developmental programming: Obesity and related disorders:

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Section: Accelerated Postnatal Growth Hypothesismentioning

confidence: 99%

Early nutrition programming of long-term health

et al. 2012

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“…Several studies observed IGF I levels to positively correlate with current growth parameters and preceding growth velocity in preterm as well as healthy term infants (17)(18)(19)(20). In contrast, findings concerning the correlation between IGF I levels and subsequent growth velocity are inconclusive ( Table 1).…”

Section: The Role Of Igf I In Growth and Body Compositionmentioning

confidence: 55%

“…Socha et al demonstrated that infants fed high-protein followup formula had higher IGF I levels than those fed low-protein follow-up formula (19). Moreover, a minimal caloric as well as a minimal protein intake has to be reached to maintain normal IGF I levels (12).…”

Section: Igf I and Dietary Proteinsmentioning

confidence: 99%

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

2014

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“…Infant nutrition may also programme the hypothalamic-pituitary-adrenal axis. For example, insulin-like growth factor 1 concentrations are lower in breast-fed compared with formula-fed infants (who have more rapid weight gain) and, in a large randomised controlled trial, lower in infants given a standard v. a high protein infant formula (38) . However, whether these effects on insulin-like growth factor 1 persist into adult life, and their impact on development of appetite regulation, obesity (particularly visceral adiposity) and CVD are presently unknown.…”

Section: Endocrine Mechanismsmentioning

confidence: 99%

The role of infant nutrition in the global epidemic of non-communicable disease

Singhal

2016

Proc. Nutr. Soc.

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Non-communicable diseases (NCD) and atherosclerotic CVD in particular, are the most important health problems of the 21st century. Already in every world region except Africa, NCD account for greater mortality than communicable, maternal, perinatal and nutritional conditions combined. Although modifiable lifestyle factors in adults are the main determinants, substantial evidence now suggests that factors in early life also have a major role in the development of NCD; commonly referred to as the Developmental Origins of Health and Disease hypothesis. Factors in utero, early postnatal life and throughout childhood, have been shown to affect NCD by influencing risk factors for CVD such as obesity, diabetes, hypertension and dyslipidaemia. Infant nutrition (e.g. breastfeeding rather than bottle feeding) and a slower pattern of infant weight gain have been shown to be particularly protective against later risk of obesity and CVD in both low-and high-income countries. The mechanisms involved are poorly understood, but include epigenetic changes; effects on endocrine systems regulating body weight, food intake and fat deposition; and changes in appetite regulation. As a consequence, strategies to optimise early life nutrition could make a major contribution to stemming the current global epidemic of NCD. This review will consider the role of early life factors in the development of NCD, focusing on the impact of infant nutrition/growth on obesity and CVD. The review will highlight the experimental (randomised) evidence where available, briefly summarise the underlying mechanisms involved and consider the implications for public health.

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Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial

Abstract: HP intake stimulates the IGF-I axis and insulin release in infancy. IGF-I enhances growth during the first 6 mo of life. This trial was registered at clinicaltrials.gov as NCT00338689.

Cited by 188 publications

References 62 publications

Early nutrition programming of long-term health

Early nutrition programming of long-term health

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

The role of infant nutrition in the global epidemic of non-communicable disease

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