Milk fat synthesis and secretion: molecular and cellular aspects

Clegg, Roger A.; Barber, Michael C.; Pooley, L; Ernens, Isabelle; Larondelle, Yvan; Travers, Maureen T.

doi:10.1016/s0301-6226(01)00194-4

Cited by 50 publications

(43 citation statements)

References 52 publications

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“…Partitioning among tissues could be a result of tissue-specific changes in fatty acid binding and transport proteins (Clegg et al, 2001;Glatz et al, 2010). Fasting NES pups show decreases in adipose fatty acid transporters across the fast (Viscarra et al, 2012) and several fatty acid transport and binding proteins have been quantified in skeletal muscle (Robbins, 2014).…”

mentioning

confidence: 99%

Adiposity and fat metabolism during combined fasting and lactation in elephant seals

Fowler

Champagne

Crocker

2018

Journal of Experimental Biology

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Animals that fast depend on mobilizing lipid stores to power metabolism. Northern elephant seals (Mirounga angustirostris) incorporate extended fasting into several life-history stages: development, molting, breeding and lactation. The physiological processes enabling fasting and lactation are important in the context of the ecology and life history of elephant seals. The rare combination of fasting and lactation depends on the efficient mobilization of lipid from adipose stores and its direction into milk production. The mother elephant seal must ration her finite body stores to power maintenance metabolism, as well as to produce large quantities of lipid and proteinrich milk. Lipid from body stores must first be mobilized; the action of lipolytic enzymes and hormones stimulate the release of fatty acids into the bloodstream. Biochemical processes affect the release of specific fatty acids in a predictable manner, and the pattern of release from lipid stores is closely reflected in the fatty acid content of the milk lipid. The content of the milk may have substantial developmental, thermoregulatory and metabolic consequences for the pup. The lactation and developmental patterns found in elephant seals are similar in some respects to those of other mammals; however, even within the limited number of mammals that simultaneously fast and lactate, there are important differences in the mechanisms that regulate lipid mobilization and milk lipid content. Although ungulates and humans do not fast during lactation, there are interesting comparisons to these groups regarding lipid mobilization and milk lipid content patterns.

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confidence: 99%

Adiposity and fat metabolism during combined fasting and lactation in elephant seals

Fowler

Champagne

Crocker

2018

Journal of Experimental Biology

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“…In the mammary gland of ruminant animals, short and medium chain saturated fatty acids are the major products of de novo lipogenesis whereas plasma lipids contribute longer chain and mono unsaturated species. The acetate is the precursor of fatty acids synthesis in ruminants, while in monogastric animals, the precursor is glucose (Clegg et al, 2001). …”

Section: Synthesis and Composition Of Goat Milk Fatmentioning

confidence: 99%

“…Several names could be found for conjugated linoleic acid, most often conjugated linoleic acid, then rumenic or ruminal acid or cis-9, trans-11 octadecadienoic acid. It is one of those found only in ruminants and is a product of incomplete hydrogenation of fatty acids in the rumen (Clegg et al, 2001;Chouinard et al, 1999). In goats fed with fish oil (Gulati et al, 2000) mainly vaccenic fatty acid is formed due to the altered pattern of the biohydrogenation.…”

Section: Composition Of Fatty Acids In Goat Milkmentioning

confidence: 99%

The Effect of Fatty Acids in Goat Milk on Health

Kompan¹,

Komprej²

2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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“…The fatty acid synthase and the fatty acid-binding protein belong to the lipid metabolism. The first is one of the major enzymes involved in the de novo lipogenesis (Clegg et al, 2001); the second provides the mammary gland with long fatty acids uptaken from blood (Jones et al, 1988).…”

Section: Protein Descriptionmentioning

confidence: 99%