Milk enriched with phytosterols reduces plasma cholesterol levels in healthy and hypercholesterolemic subjects

Gonçalves, Sónia; Maria, Vasco A. J.; Silva-Herdade, Ana Santos; Silva, João Martins e; Saldanha, Carlota

doi:10.1016/j.nutres.2007.03.003

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…Caco-2 cells have the capacity to elicit proinflammatory responses in response to stimuli such as bacterial endotoxin lipopolysaccharide (LPS) 16 and tumor necrosis factor alpha (TNF-α). 21 a Bovine milk hydrolysates exhibit clinically observable effects on conditions such as type 2 diabetes mellitus, 7 obesity 8 and hypertension 9 as well as influencing plasma cholesterol levels 10 and the activity of angiotensin-converting enzyme (ACE) 11 and immune responses. 15 Caco-2 cells lack the cellular diversity present within the baso-lateral side of the intestinal epithelium of intact tissue 18 and hence, explants from intestinal tissue with their inherent heterogeneity, are also informative in-terms of studying the effects of bioactive compounds on both tissue physiology and immune responses under normal conditions and following microbial infection.…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory potential of a moderately hydrolysed casein and its 5 kDa fraction in in vitro and ex vivo models of the gastrointestinal tract

et al. 2015

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Bioactive peptides from milk can impart a wide range of physiological benefits without the allergies and intolerance associated with the consumption of whole milk. The objective of this study was to characterise the anti-inflammatory properties of intact sodium caseinate (NaCAS), a moderately hydrolysed NaCAS enzyme hydrolysate (EH) and its 5 kDa fraction (5kDaR), in both in vitro and ex vivo systems. In vitro, Caco-2 cells were stimulated with tumor necrosis factor (TNF) α and co-treated ± casein hydrolysates or dexamethasone (control). The inflammatory marker interleukin (IL)-8 was measured by ELISA in the supernatant at 24 h. Ex vivo, porcine colonic tissues were stimulated with lipopolysaccharide (LPS) and co-treated with casein hydrolysates for 3 h from which the relative expression of a panel of cytokines was measured in vitro. While the steroid dexamethasone brought about a 41.6% reduction in the IL-8 concentration in the supernatant, the 5kDaR reduced IL-8 by 59% (P < 0.05) when compared to the TNFα stimulated Caco-2 cells. In the ex vivo system, 5kDaR was associated with decreases in IL-1α, IL-1β, IL-8 and TGF-β expression and an increase in IL-17 expression (P < 0.05) relative to the LPS challenged tissues. We concluded, that a 5 kDa casein fraction demonstrates potent anti-inflammatory effects both in in vitro and ex vivo models of the gastrointestinal tract.

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Section: Introductionmentioning

confidence: 99%

The anti-inflammatory potential of a moderately hydrolysed casein and its 5 kDa fraction in in vitro and ex vivo models of the gastrointestinal tract

et al. 2015

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“…In fact, in addition to these, dairy products present a further interest as functional foods. In this context, milk and yogurts have been enriched with phytosterols, with the claim of reduction of total cholesterol and low density lipoprotein-cholesterol (LDL-C) plasmatic levels, known risk factors of cardiovascular disease (EFSA (European Food Safety Authority) 2008; Jones and Jew 2007;Moreau et al 2002;Gonçalves et al 2007). …”

Section: Introductionmentioning

confidence: 99%

“…These foods, easily included in a healthy diet, possess comparable efficacy with the fat-rich ones (AbuMweis et al 2008;Mannarino et al 2009). Yogurts possess an additional advantage since with a single dose it is possible to attain the optimal daily intake (Gonçalves et al 2007;AbuMweis et al 2008;Mannarino et al 2009;Ramos and Saraiva 2010).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Phytosterols in Milk and Yogurts Used as Functional Foods in Portugal

et al. 2010

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The early development of cardiovascular diseases, one of the major death causes in Europe, is clearly associated with high plasmatic cholesterol levels. However, it is demonstrated that the ingestion of phytosterolsenriched milk and yogurts could reduce cholesterolemia. The purpose of the present work was to assess the commercially available phytosterols-enriched milk and yogurts. As such, the available three milk and seven yogurt presentations in Portuguese market were collected during 2008 and analyzed through gas chromatography coupled with mass detection. All the analyzed milk samples were in agreement with the proportion established by the European Commission, with β-sitosterol as the more abundant phytosterol. However, and contrarily to milk, the different yogurt manufacturers had different options in the phytosterols added to the dairy foods commercialized.

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“…A study investigated the effect of phytosterols added into milk on plasma concentrations of total cholesterol, high-density lipoprotein cholesterol (HDL-C), and LDL-C, and on biochemical, hematologic, and hemorheological profiles in healthy and hypercholesterolemic subjects in Portugal. The results obtained in this study indicate that phytosterolenriched milk is a good vehicle for reducing plasma cholesterol in hypercholesterolemic subjects (Goncalves et al, 2007).Elevated plasma total cholesterol (TC) 5 and LDL-cholesterol (LDL-C) are a major risk factor for coronary heart disease (CHD). Phytosterols (plant sterols and stanols) are among the dietary options available to lower elevated plasma TC and LDL-C concentrations.…”

Section: Phytosterol Enriched Products For the Control Of Ldl Cholestmentioning

confidence: 84%

The Role of Phytosterols Enriched Foods-A Review

Raju¹

2013

IOSR-JESTFT

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Milk enriched with phytosterols reduces plasma cholesterol levels in healthy and hypercholesterolemic subjects

Cited by 16 publications

References 32 publications

The anti-inflammatory potential of a moderately hydrolysed casein and its 5 kDa fraction in in vitro and ex vivo models of the gastrointestinal tract

The anti-inflammatory potential of a moderately hydrolysed casein and its 5 kDa fraction in in vitro and ex vivo models of the gastrointestinal tract

Evaluation of Phytosterols in Milk and Yogurts Used as Functional Foods in Portugal

The Role of Phytosterols Enriched Foods-A Review

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