Mildly Elevated Serum Creatinine Concentration Correlates With the Extent of Coronary Atherosclerosis

Černe, Darko; Kaplan-Pavlovčič, Staša; Kranjec, Igor; Jürgens, Günther

doi:10.1081/jdi-100101965

Cited by 31 publications

(23 citation statements)

References 23 publications

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“…However, although, it was previously indicated (1,2,22), association of degree of renal function and angiographic extent of CAD in both sexes was not Creatinine, mg/dl evaluated before. In our study, we have shown that patients without overt renal disease, stratified according to level of Cr, differ from each other in terms of angiographic extent of CAD, defined according to definition and previously validated (10).…”

Section: Discussionmentioning

confidence: 85%

Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris

Korkmaz¹,

Demirkan²,

Altay³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Renal bozukluğun kardiyovasküler olaylar için yüksek riskle bağlantılı olduğu gösterilmiştir. Kreatinin yüksekliğinin hafif formları bile kötü kardiyovasküler sonuçlarla ilişkilidir. Aşikar renal bozukluğun olmadığı hastalarda kreatinin düzeyleri ile koroner arter hastalığının anjiyografik yaygınlığının ilişkisini araştırmak için retrospektif bir çalışma tasarlandı. Yöntemler: Tipik kararlı anjina pektoris ile Türkiye Yüksek İhtisas hastanesine başvuran ve diyaliz öyküsü olmadan kreatinin düzeyi ≤3 mg/dl olan 892 ardışık hasta (ortalama yaşı 62±10 yıl olan 311'i kadın ve ortalama yaşı 56±11 yıl olan 581 erkek) retrospektif olarak tarandı. Aşikar renal hastalığı ABSTRACT Objective: Renal dysfunction has been shown to be linked to high risk for cardiovascular events. Even milder forms of creatinine elevation are associated with poor cardiovascular outcomes. We designed a retrospective study and searched the association of angiographic extent of coronary artery disease and creatinine levels in patients without overt renal dysfunction. Methods: We retrospectively reviewed 892 consecutive patients with typical stable angina pectoris (311 female with mean age of 62±10 years, 581 male with mean age of 56±11 years) at Türkiye Yüksek İhtisas Hospital and creatinine level ≤3 mg/dl without history of hemodialysis. Patients without overt renal disease were divided into 3 groups according to level of creatinine (Group A: Cr level <1.2 mg/dl, Group B: Cr level ≥1.2 and <1.5 mg/dl and Group C: Cr level ≥1.5 -≤3 mg/dl). Additionally after evaluation of coronary angiograms, patients were also classified according to those with high stenosis (stenosis score ≥16) and high extension scores (extension score >50%) versus low stenosis and low extension scores. Logistic regression analysis was performed to establish the clinical predictors of high total stenosis and high extension scores.

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Section: Discussionmentioning

confidence: 85%

Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris

Korkmaz¹,

Demirkan²,

Altay³

et al. 2011

Anadolu Kardiyol Derg

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“…The strong association between renal function and mortality can be explained in several ways. First, mild renal dysfunction is associated with generalized atherosclerosis and vascular damage (19 ). Second, mild renal dysfunction is associated with a higher incidence of known cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C for Enhancement of Risk Stratification in Non–ST Elevation Acute Coronary Syndrome Patients with an Increased Troponin T

Windhausen

Hirsch²,

Fischer

et al. 2009

Clinical Chemistry

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“…One reason seems to be that renal dysfunction indicates a generalized atherosclerosis and vascular damage. 16 In accor- . For troponin T, patients were categorized into those with a value Ͻ0.01 g/L and 3 equally sized groups with a value Ն0.01 g/L.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C

Jernberg¹,

Lindahl²,

James³

et al. 2004

Circulation

217

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Background-Patients with suspected or confirmed non-ST-elevation acute coronary syndrome (ACS) constitute a large and heterogeneous group. Measurements of renal function such as serum creatinine and estimation of creatinine clearance carry independent prognostic information in this population. Cystatin C is a new and better marker of renal function than creatinine. The aim was therefore to evaluate the prognostic value of cystatin C in this population. Methods and Results-Cystatin C was analyzed on admission in 726 patients admitted because of symptoms suggestive of an acute coronary syndrome and no ST-segment elevations. Patients were followed up with regard to death and myocardial infarction for a median of 40 and 6 months, respectively. The median cystatin C level was 1.00 mg/L (25th to 75th percentile, 0.83 to 1.24 mg/L). The risk of death during follow-up increased with increasing levels of cystatin C. In the group with non-ST-elevation ACS, patients in the second, third, and fourth quartiles had a relative risk of subsequent death of 1.8 (95% CI, 0.6 to 5.3), 3.2 (95% CI, 1.2 to 8.5), and 11.7 (95% CI, 4.7 to 29.3) compared with the lowest quartile. In Cox regression models including well-known predictors of outcome, cystatin C level was independently associated with mortality but not with the risk of subsequent myocardial infarction. In a comparison of the markers of renal function in receiver-operating curve analyses, cystatin C had the best ability to discriminate between survivors and nonsurvivors. Conclusions-A single measurement of cystatin C will substantially improve the early risk stratification of patients with suspected or confirmed non-ST-elevation ACS.

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Mildly Elevated Serum Creatinine Concentration Correlates With the Extent of Coronary Atherosclerosis

Cited by 31 publications

References 23 publications

Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris

Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris

Cystatin C for Enhancement of Risk Stratification in Non–ST Elevation Acute Coronary Syndrome Patients with an Increased Troponin T

Cystatin C

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