Serum creatinine is independently associated with angiographic extent of coronary artery disease in patients with stable angina pectoris

Abstract

ÖZETAmaç: Renal bozukluğun kardiyovasküler olaylar için yüksek riskle bağlantılı olduğu gösterilmiştir. Kreatinin yüksekliğinin hafif formları bile kötü kardiyovasküler sonuçlarla ilişkilidir. Aşikar renal bozukluğun olmadığı hastalarda kreatinin düzeyleri ile koroner arter hastalığının anjiyografik yaygınlığının ilişkisini araştırmak için retrospektif bir çalışma tasarlandı. Yöntemler: Tipik kararlı anjina pektoris ile Türkiye Yüksek İhtisas hastanesine başvuran ve diyaliz öyküsü olmadan kreatinin düzeyi ≤3 mg/dl olan 892 ardışık hasta (ortalama yaşı 62±10 yıl olan 311'i kadın ve ortalama yaşı 56±11 yıl olan 581 erkek) retrospektif olarak tarandı. Aşikar renal hastalığı ABSTRACT Objective: Renal dysfunction has been shown to be linked to high risk for cardiovascular events. Even milder forms of creatinine elevation are associated with poor cardiovascular outcomes. We designed a retrospective study and searched the association of angiographic extent of coronary artery disease and creatinine levels in patients without overt renal dysfunction. Methods: We retrospectively reviewed 892 consecutive patients with typical stable angina pectoris (311 female with mean age of 62±10 years, 581 male with mean age of 56±11 years) at Türkiye Yüksek İhtisas Hospital and creatinine level ≤3 mg/dl without history of hemodialysis. Patients without overt renal disease were divided into 3 groups according to level of creatinine (Group A: Cr level <1.2 mg/dl, Group B: Cr level ≥1.2 and <1.5 mg/dl and Group C: Cr level ≥1.5 -≤3 mg/dl). Additionally after evaluation of coronary angiograms, patients were also classified according to those with high stenosis (stenosis score ≥16) and high extension scores (extension score >50%) versus low stenosis and low extension scores. Logistic regression analysis was performed to establish the clinical predictors of high total stenosis and high extension scores.

A new coronary artery disease grading system correlates with numerous routine parameters that were associated with atherosclerosis: a grading system for coronary artery disease severity

“…Serum creatinine was shown to be an independent predictor of coronary heart disease mortality in normotensive and normal-weighted survivors of a myocardial infarction but with pre-existing renal disease or heart failure 19. In patients with chest pain undergoing angiography, creatinine correlated with the extent of CAD 20. Consequently, the tested score seems to confirm data from other study groups concerning creatinine.…”

D-dimer to Creatinine Ratio: A Novel Biomarker Associated with Gensini Score in ST-Segment Elevation Myocardial Infarction Patients

“… 34 Serum creatinine levels have been shown to be an independent predictor of the severity and short-term outcome in patients with coronary artery disease. 31 , 35 , 36 …”

Association of Creatinine Clearance Rate and Coronary Angiographic Severity in Patients with Coronary Artery Disease

“…19 Creatinine was shown to be significantly correlated with both stenosis and extension scores. 19 In this study, vessel score and stenosis score, which are parameters of angiographic severity of CAD, had progressive increasing association with progressively decreasing renal function that is indicated by CCr. So, angiographic severity of coronary artery disease (CAD) is inversely related to CCr level.…”

“…Mildly increased serum creatinine is probably a marker for unmeasured proatherogenic factors. 16 In Turkey Korkmaz et al 19 reviewed 892 consecutive patients with typical stable angina pectoris and showed that those in the highest creatinine group (>1.5 mg/dl, but not above 3 mg/ dl) had the highest total stenosis score (17±6, p<0.05) and extension score (78±25, p<0.05) irrespective of age and gender. 19 Creatinine was shown to be significantly correlated with both stenosis and extension scores.…”

“…16 In Turkey Korkmaz et al 19 reviewed 892 consecutive patients with typical stable angina pectoris and showed that those in the highest creatinine group (>1.5 mg/dl, but not above 3 mg/ dl) had the highest total stenosis score (17±6, p<0.05) and extension score (78±25, p<0.05) irrespective of age and gender. 19 Creatinine was shown to be significantly correlated with both stenosis and extension scores. 19 In this study, vessel score and stenosis score, which are parameters of angiographic severity of CAD, had progressive increasing association with progressively decreasing renal function that is indicated by CCr.…”