Mild weight loss reduces inflammatory cytokines, leukocyte count, and oxidative stress in overweight and moderately obese participants treated for 3 years with dietary modification

Chae, Jey Sook; Paik, Jean Kyung; Kang, Ryungwoo; Kim, Minjoo; Choi, Yongin; Lee, Sang Hyun; Lee, Jong Ho

doi:10.1016/j.nutres.2013.01.005

Cited by 58 publications

(60 citation statements)

References 42 publications

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“…Posthoc analysis using the Tukey test revealed that patients with schizophrenia had higher WBC than patients with unipolar depression (p = 0.04), patients with bipolar depression had LYMPH% higher than patients with schizophrenia (p = 0.001), bipolar mania (p = 0.017) and unipolar depression (p = 0.003), while patients with unipolar depression had EO% higher than patients with schizophrenia (p = 0.008). For the whole study group there was a significant differences between men and women for WBC (6.93±2.00 vs. 6 Table 4 shows distribution of low, normal and high ranges of blood cells parameters in the study groups. Patients with bipolar mania had the highest percentage of abnormal results for WBC (both below and above normal range -8.3% and 7.1%, respectively), MONO% below normal range (17.9%) and NEUT# below normal range (9.2%).…”

Section: Resultsmentioning

confidence: 91%

“…[0, 4,6] according to DSM-IV), which included: bipolar depression (F31.3-F31.5 according to ICD-10, 296.6 according to DSM-IV) and bipolar mania (F30 and F31.0-F31.2 according to ICD-10, 296.0 and 296.4 according to DSM-IV). In our unit diagnosis is based on the ICD-10 criteria, DSM-IV codes were given as reference.…”

Section: Methodsmentioning

confidence: 99%

“…Archives of Psychiatry and Psychotherapy, 2017; 3: 16-26 [3,5,6], smoking (positive correlation) [2,7], alcohol consumption (inverse association) [3,8], exposure to benzene (leukocytopenia) [2]. Sun et al concluded that subnormal WBC counts (<3.9 × 10 9 cells/L), which rather exclude even lowgrade systemic inflammation, are related to the lower prevalence of metabolic syndrome and the lowest incidence of metabolic syndrome during a 5-year follow-up period among healthy population than WBC counts within reference range [9].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of white blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder

Wysokiński¹,

Margulska²

2017

Arch Psych Psych

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SummaryObjective: We compared white blood cells parameters (total white blood cells (WBC), lymphocytes count (LYMPH#) and percentage (LYMPH%), monocytes count (MONO) and percentage (MONO%), basophils count (BASO#) and percentage (BASO%), eosinophils count (EO#) and percentage (EO%), neutrophils count (NEUT#) and percentage (NEUT%)) in patients with schizophrenia (SHZ), unipolar depression (UD) and bipolar disorder (BIP): bipolar depression (BD) and mania (BM).Methods: This was a retrospective, cross-sectional, naturalistic study of 2381 patients (SHZ n=1244; UD n=794; BIP n=343, BD n=259, BM n=84). WBC as well as differential leukocytes count were measured using automated hematology analyzer.Results: There were significant differences between study groups (WBC, p=0.02; LYMPH# p=0.03; LYMPH% p=0.008; EO% p <0.001). Age and sex affected various white blood cells parameters.Conclusions: There are differences in white blood cells between study groups. Highest WBC was in the schizophrenia and bipolar mania groups, while patients with BM had lowest LYMPH%. Highest frequency of below or above normal WBC was found in patients with BM.

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Section: Resultsmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of white blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder

Wysokiński¹,

Margulska²

2017

Arch Psych Psych

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“…We identified 15 studies investigating the effect of weight loss interventions (diet- and/or exercise-, and surgery-induced) on individuals' oxidative stress level (table 1): 6 RCTs and 9 non-randomized intervention studies (n = 5 diet, n = 6 diet and/or exercise interventions, and n = 3 bariatric surgery interventions) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48].…”

Section: Resultsmentioning

confidence: 99%

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

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Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

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“…Obesity-related type 2 diabetes is associated with chronic inflammation [49][50][51] and IL-1β levels have been shown to be correlated with obesity and obesity related disorders. Individuals with combined elevated plasma levels of IL-1β and IL-6 are at increased risk for developing type 2 diabetes [52], but even mild weight loss in obese patients resulted in a 45% decrease in serum IL-1β levels over a three-year study period [53]. Leptin, an adipocytokine involved in the pathogenesis of insulin resistance necessary for developing type 2 diabetes, induces β-cell apoptosis and impaired β-cell function by promoting IL-1β production in human pancreatic islets [54].…”

Section: Discussionmentioning

confidence: 99%

Urinary interleukin-1ß levels among gynecological patients

Woolery

Hoffman

Kraft

et al. 2014

Journal of Ovarian Research

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Background: Early detection of epithelial ovarian cancer (OC) is necessary to overcome the high mortality rate of late stage diagnosis; and, examining the molecular changes that occur at early disease onset may provide new strategies for OC detection. Since the deregulation of inflammatory mediators can contribute to OC development, the purpose of this pilot study was to determine whether elevated urinary levels of Interleukin-1beta (IL-1 beta) are associated with OC and associated clinical parameters. Methods: Urinary and serum levels of IL-1 beta were analyzed by ELISA from a patient cohort consisting of healthy women (N = 10), women with ovarian benign disease (N = 23), women with OC (N = 32), women with other benign gynecological conditions (N = 22), and women with other gynecological cancers (N = 6). Results: Average urinary IL-1 beta levels tended to be elevated in ovarian benign (1.26 pg/ml) and OC (1.57 pg/ml) patient samples compared to healthy individuals (0.36 pg/ml). Among patients with benign disease, urinary IL-1β levels were statistically higher in patients with benign inflammatory gynecologic disease compared to patients with non-inflammatory benign disease. Interestingly, urinary IL-1 beta levels tended to be 3-6x greater in patients with benign ovarian disease or OC as well as with a concomitant family history of ovarian and/or breast cancer compared to similar patients without a family history of ovarian and/or breast cancer. Lastly, there was a pattern of increased urinary IL-1 beta with increasing body mass index (BMI); patients with a normal BMI averaged urinary IL-1 beta levels of 0.92 pg/ml, overweight BMI averaged urinary IL-1 beta levels of 1.72 pg/ml, and obese BMI averaged urinary IL-1 beta levels of 5.26 pg/ml. Conclusions: This pilot study revealed that urinary levels of IL-1 beta are elevated in patients with epithelial OC supporting the thought that inflammation might be associated with cancer progression. Consequently, further studies of urinary IL-1 beta and the identification of an inflammatory profile specific to OC development may be beneficial to reduce the mortality associated with this disease.

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Mild weight loss reduces inflammatory cytokines, leukocyte count, and oxidative stress in overweight and moderately obese participants treated for 3 years with dietary modification

Cited by 58 publications

References 42 publications

Comparison of white blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder

Comparison of white blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

Urinary interleukin-1ß levels among gynecological patients

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