Comparison of white blood cells parameters 
in patients with acute schizophrenia, unipolar 
depression and bipolar disorder

Wysokiński, Adam; Margulska, Aleksandra

doi:10.12740/app/76508

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…It is, therefore, possible that elevated levels of these cytokines in schizophrenic patients may increase the number of neutrophils in the blood, but do not significantly affect the number of lymphocytes. Such activity could be associated with increased NLR values in the period of and would be consistent with the reports on the increased number of neutrophils in the blood in patients diagnosed with schizophrenia, while the number of lymphocytes in the blood of this group of patients was within the normal range [ 41 ]. At the same time, the decreasing levels of these cytokines, especially IFN-γ, due to the action of antipsychotic drugs, could reduce the NLR presented by the results of our study.…”

Section: Discussionsupporting

confidence: 90%

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study

Dawidowski

Grelecki

Biłgorajski

et al. 2021

JCM

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Background: Studies have shown that there are deviations in the results of peripheral blood counts, which lead to increased values of the neutrophils-to-lymphocytes ratio (NLR) in schizophrenia. Antipsychotic drugs have proven to lower the levels of pro-inflammatory cytokines and a growing number of studies indicate a similar effect on NLR values. Methods: We identified inpatients with schizophrenia and collected data of NLR at the beginning (NLR1) and end (NLR2) of hospitalization, the status of antipsychotic medication on admission and potential confounding factors. In the statistical analysis, we applied a linear mixed model. Results: After the inclusion and exclusion process the records of 40 patients (np = 40) and 71 hospitalizations (nh = 71) were analyzed. We found that in the group of antipsychotics-naive patients, the NLR1 were significantly higher than the NLR2 values. Such a difference did not occur in the case of non-antipsychotics-naïve patients. Age and the diagnosis of hypothyroidism influenced the value of change in NLR from the beginning to the end of hospitalization in a given patient (ΔNLR). Conclusions: The study confirmed the lowering effect of antipsychotics on NLR values in psychosis. The NLR may potentially be a tool for assessing response to treatment with antipsychotics.

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Section: Discussionsupporting

confidence: 90%

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study

Dawidowski

Grelecki

Biłgorajski

et al. 2021

JCM

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“…The exciting finding is that most of the variants found and three variants related to BD were related to hemogram parameters, such as lymphocyte percentage, nucleated red blood cell, neutrophil count, lymphocyte counts, eosinophil counts, haemoglobin concentration, white blood cell count, haematocrit, plateletcrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular volume. The relationship among these indicators and BD has been concluded in various epidemiological studies (Altshuler et al, 2008;Wysokiński & Margulska, 2017;Ivković et al, 2016;Cevher Binici et al, 2018;Çakır et al, 2015;Wysokiński et al, 2015;Wysokiński & Szczepocka, 2018;Mert & Terzi, 2016;Mutz et al, 2021). During manic episodes, inflammatory cells (absolute neutrophil count, platelet count, plateletcrit and mean platelet volume) and ratios (neutrophil-lymphocyte ratio, platelet-lymphocyte ratio) appear to be altered, according to hemogram readings of individuals with BD compared to those of a healthy control group (Mert & Terzi, 2016).…”

Section: Discussionmentioning

confidence: 97%

Using the Bayesian variational spike and slab model in a genome‐wide association study for finding associated loci with bipolar disorder

Kazemi Naeini,

Akbarzadeh,

Kazemi

et al. 2023

Annals of Human Genetics

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ObjectiveThe genome‐wide association studies (GWAS) analysis, the most successful technique for discovering disease‐related genetic variation, has some statistical concerns, including multiple testing, the correlation among variants (single‐nucleotide polymorphisms) based on linkage disequilibrium and omitting the important variants when fitting the model with just one variant. To eliminate these problems in a small sample‐size study, we used a sparse Bayesian learning model for finding bipolar disorder (BD) genetic variants.MethodsThis study used the Wellcome Trust Case Control Consortium data set, including 1998 BD cases and 1500 control samples, and after quality control, 380,628 variants were analysed. In this GWAS, a Bayesian logistic model with hierarchical shrinkage spike and slab priors was used, with all variants considered simultaneously in one model. In order to decrease the computational burden, an alternative inferential method, Bayesian variational inference, has been used.ResultsThirteen variants were selected as associated with BD. The three of them (rs7572953, rs1378850 and rs4148944) were reported in previous GWAS. Eight of which were related to hemogram parameters, such as lymphocyte percentage, plateletcrit and haemoglobin concentration. Among selected related genes, GABPA, ELF3 and JAM2 were enriched in the platelet‐derived growth factor pathway. These three genes, along with APP, ARL8A, CDH23 and GPR37L1, could be differential diagnostic variants for BD.ConclusionsBy reducing the statistical restrictions of GWAS analysis, the application of the Bayesian variational spike and slab models can offer insight into the genetic link with BD even with a small sample size. To uncover related variations with other traits, this model needs to be further examined.

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“…Elevated levels of white blood cells (WBC) and C-reactive protein (CRP) have been associated with mortality (Willems et al, 2010) and chronic disease (B. J. Miller et al, 2015), including depression (Chamberlain et al, 2017; Wysokiński and Margulska, 2017). Prior evidence demonstrates that diet can have both pro- and anti-inflammatory properties (Calder and Yaqoob, 2013; Galland, 2010) capable of stimulating pathways associated with neurobiology of mood disorders (Miller et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inflammation as a unique marker of suicide ideation distinct from depression syndrome among U.S. adults

Bergmans

Kelly

Mezuk

2019

Journal of Affective Disorders

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Background: Recent evidence suggests that pro-inflammatory states may be independently associated with the risk of suicidality, above and beyond depression. This study assesses whether four indicators of inflammation, circulating levels of C-reactive protein (CRP), white blood cell (WBC) count and immunoglobulin E (IgE), and dietary inflammatory potential, measured using the Dietary Inflammatory Index® (DII), distinguish suicidal ideation (SI) from major depression (MD). Methods: Data come from multiple cycles of the US National Health and Nutrition Examination Survey (NCRP&WBC = 13,912; NDII = 17,076; NIgE = 4,060). MD was measured using the Patient Health Questionnaire-9 (PHQ-9); SI was indicated by the last item of the PHQ-9. To assess SI independent from MD, participants were classified into four categories: SI with MD, SI without MD, MD without SI, and neither MD nor SI. Regression models were used to assess the relationship between indicators of inflammation and SI with and without MD. Results: None of the inflammatory indicators were able to distinguish SI status among MD cases. DII was associated with SI among individuals without MD. CRP, DII, and WBC were associated with MD. No associations were found for IgE. Limitations: Cross-section data prevent drawing causal conclusions. Underreporting of MD and suicidal ideation and measurement of habitual diet using 24 h dietary recalls are also weaknesses. Conclusion: Dietary inflammatory potential was associated with suicide ideation among US adults with and without depression. Diet may play a role in suicide ideation and more empirical evidence is needed to determine whether nutritional protocols could aid in the treatment of suicidal behaviors. Findings did not support inflammatory factors having a relationship with suicide ideation distinct from depression.

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Comparison of white blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder

Cited by 3 publications

References 26 publications

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study

Using the Bayesian variational spike and slab model in a genome‐wide association study for finding associated loci with bipolar disorder

Inflammation as a unique marker of suicide ideation distinct from depression syndrome among U.S. adults

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