Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer

Li, Caiying; Li, Tan; Niu, K X; Xiao, Zecong; Huang, Jing; Pan, Ximin; Sun, Yi; Wang, Yongchen; Ma, Decai; Xie, Peiyi; Shuai, Xintao; Meng, Xiaochun

doi:10.1039/d2bm00505k

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…After accumulating in colorectal tumors, MnO 2 NPs were reduced to Mn 2+ in TME, which could be further used as the MRI contrast agent for tumor imaging. 148 The light in first NIR optical window (NIR-I, 750-1000 nm) is mainly used in PTT. However, the depth of the penetration limits its efficacy to a certain extent.…”

Section: Immunotherapy Combined With Photothermal Therapymentioning

confidence: 99%

“…This indicated that the NPs could cooperate with the mild photothermal effect to enhance the anti-tumor immunity of the body. 148 However, existing photothermal immunotherapy is limited by the complexity of TME and the depth of tissue penetration of light. To improve the effectiveness of combination therapy, Li and colleagues proposed a strategy of combining Mn 2+ with PTT, which could promote CDT and maximize the ICD of tumors.…”

Section: Immunotherapy Combined With Photothermal Therapymentioning

confidence: 99%

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Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

Cao,

Li,

Ren

et al. 2024

J. Mater. Chem. B

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Section: Immunotherapy Combined With Photothermal Therapymentioning

confidence: 99%

Section: Immunotherapy Combined With Photothermal Therapymentioning

confidence: 99%

Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

Cao,

Li,

Ren

et al. 2024

J. Mater. Chem. B

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“…Li et al. reported MnO 2 @MPDA-PEG nanoparticles, through the incorporation of MnO 2 into polyethylene glycolate mesoporous polydopamine nanoparticles (MPDA-PEG nanoparticles) as a kind of mild photothermal effect assisted nanosystem ( 101 ). In colorectal tumors, nano drugs can release Mn 2+ in the tumor microenvironment, which can be used as immune adjuvants to promote DC maturation and T cell activation.…”

Section: The Significance Of Mno 2 For Cgas-sting ...mentioning

confidence: 99%

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Zhang

et al. 2023

Front. Immunol.

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As an essential micronutrient, manganese plays an important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous and endogenous DNA for activation, has been widely reported to play critical roles in the innate immunity against some important diseases, such as infections and tumor. Manganese ion (Mn2+) has been recently proved to specifically bind with cGAS and activate cGAS-STING pathway as a potential cGAS agonist, however, is significantly restricted by the low stability of Mn2+ for further medical application. As one of the most stable forms of manganese, manganese dioxide (MnO2) nanomaterials have been reported to show multiple promising functions, such as drug delivery, anti-tumor and anti-infection activities. More importantly, MnO2 nanomaterials are also found to be a potential candidate as cGAS agonist by transforming into Mn2+, which indicates their potential for cGAS-STING regulations in different diseased conditions. In this review, we introduced the methods for the preparation of MnO2 nanomaterials as well as their biological activities. Moreover, we emphatically introduced the cGAS-STING pathway and discussed the detailed mechanisms of MnO2 nanomaterials for cGAS activation by converting into Mn2+. And we also discussed the application of MnO2 nanomaterials for disease treatment by regulating cGAS-STING pathway, which might benefit the future development of novel cGAS-STING targeted treatments based on MnO2 nanoplatforms.

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“…These probes exhibit better penetration depth and better signal-to-noise ratios of the disease site in FL and PA imaging and minimize the side effects of PTT and PDT. In addition, it has been reported that nanoparticle-based PTT and PDT are able to not only ablate tumors, but also promote systemic antitumor immune activation by releasing tumor antigens and immune-stimulatory molecules [ 77 , 78 , 79 ]. Therefore, nanoprobes for PTT and PDT have great potential for use in anticancer immunotherapy.…”

Section: Nir-ii Fluorescence and Cancer Treatmentmentioning

confidence: 99%

Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer

et al. 2022

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Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics.

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Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer

Abstract: The application of MnO2@MPDA-PEG NPs for reshaping the tumor microenvironment under mild PTT inhibits tumor growth.

Cited by 9 publications

References 41 publications

Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer

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