Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans

Markovich, Zachary; Hartman, Jessica H.; Ryde, Ian T.; Hershberger, Kathleen A.; Joyce, Abigail S.; Ferguson, P. Lee; Meyer, Joel N.

doi:10.1016/j.crtox.2022.100084

Cited by 4 publications

(3 citation statements)

References 76 publications

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“…Toxicological and pharmacological studies [29] Caenorhabditis elegans Bioluminescent monitoring confirms the mitochondrial depletion of ATP by pentachlorophenol.…”

Section: Main Objects For Atp Detection Commentsmentioning

confidence: 89%

“…The results obtained with ATP-metry are valuable for the subsequent development of the functional fibrous materials, since isolation of remaining living cells of microorganisms from tissue materials with detoxifying and decontaminating protective properties for further their analyzing by traditional microbiological methods is extremely difficult, whereas ATP extraction is possible and convenient [42][43][44][45][46]. In addition, the dependence of the residual concentration of intracellular ATP in some samples on the concentration of an antimicrobial drug used for treatment of cells makes it possible to establish the minimum inhibitory concentration of the substance or the resistance of microorganisms to this substance [23,24,29].…”

Section: Main Modern Trends In the Use Of Bioluminescent Atp Determin...mentioning

confidence: 99%

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Luminescent Analysis of ATP: Modern Objects and Processes for Sensing

et al. 2022

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Bioluminescent analysis of adenosine triphosphate (ATP) concentrations is now acquiring new applications in the form of objects and processes in which it can be effectively used for sensing. A quick analysis of biological objects and systems for which the level of ATP concentrations is one of the main parameters, and a forecast of the development of various situations in such biosystems under industrial production conditions or the ecological state of the environment, confirmed by various results of analytical control of other parameters, turns out to be simple and effective. Sanitary control, quality control of purified water, microbial analysis in the food industry, maintenance of drugs and estimation of their quality, and monitoring of the metabolic state of biocatalysts used in various biotechnological processes are between the main trends of recent applications of bioluminescent ATP-assay. Additionally, the new areas of ATP sensing are developed, and the following topics are their creation of synthetic microbial consortia, their introduction as new biocatalysts to biodegradation of pesticides, suppression of methane accumulation in model urban land fields, control of dangerous development of biocorrosive processes, design of chemical-biocatalytic hybrid processes, creation of effective antimicrobial dressing and protective tissue materials, etc. These aspects are the subject of this review.

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“…Toxicological and pharmacological studies [29] Caenorhabditis elegans Bioluminescent monitoring confirms the mitochondrial depletion of ATP by pentachlorophenol.…”

Section: Main Objects For Atp Detection Commentsmentioning

confidence: 89%

Section: Main Modern Trends In the Use Of Bioluminescent Atp Determin...mentioning

confidence: 99%

Luminescent Analysis of ATP: Modern Objects and Processes for Sensing

et al. 2022

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“…Environmental residues of PCP-Na can infiltrate organisms via the respiratory tract and subsequently enter the food chain through bio-concentration [2]. These substances present potential risks including but not limited to carcinogenicity [4][5][6], endocrine-disrupting effects, cytotoxicity [7], reproductive toxicity [8], neurotoxicity [9], developmental toxicity [10], and genotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Sodium Pentachlorophenolate and Its Metabolites in Swine Samples

Jia,

Cui,

et al. 2023

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Pentachlorophenol (PCP) is a persistent organic pollutant usually present in the form of sodium salts (PCP-Na) that has been banned for many years, but it can still be detected in animal food. The present study established a method of detecting PCP-Na and its metabolites—tetrachlorocatechol (TCC), pentachlorophenol acetate (PCP-acetate), and pentachloroanisole (PCA)—in swine samples (pork, fat, liver, heart, lungs and kidney), simultaneously using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS) based on the modified QuEChERS pre-treatment method. The validation results exhibited a good sensitivity with limits of quantitation (LOQs) of 1 μg/kg–2 μg/kg. The recoveries of spiked samples were in the range of 60.5–119.9%, with a relative standard deviation (RSD) between replicates (n = 5) of between 0.70% and 12.06%.

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