Mild Hypothermia Attenuates Circulatory and Pulmonary Dysfunction During Experimental Endotoxemia*

Abstract

The induction of mild hypothermia attenuates cardiac and respiratory dysfunction and counteracts sympathetic activation during experimental endotoxemia. This was not associated with lower plasma cytokine levels, indicating a reduction of cytokine responsiveness by mild hypothermia.

Mild hypothermia (33°C) increases the inducibility of atrial fibrillation: An in vivo large animal model study

“…The experimental setup has been described before . Briefly, landrace pigs (n = 10, 67 ± 2 kg) were fasted overnight with free access to water and sedated with 0.5 mg/kg midazolam and 20 mg/kg ketamine.…”

Is the Time Right to Fight Global Warming in Sepsis?*

“…Based on the study by Schwarzl et al (11), and historical data, it appears safe to conclude that therapeutic cooling lowers increased oxygen demand induced by sepsis-associated hyperthermia, and as far as we can tell, it does not damage the heart. Furthermore, it seems that h'ypothermia reduces mortality in, at least, some animal models of septic shock.…”

“…In this issue of Critical Care Medicine, Schwarzl et al ( 11 ) report effects of mild hypothermia (33°C) induced by endovascular cooling of septic pigs. Sepsis was provoked by an IV infusion of Escherichia coli lipopolysaccharide (LPS), and cardiopulmonary, hemodynamic, and gas exchange measurements were taken over the course of 8 hours after LPS challenge.…”

“…Schwarzl et al (11) followed up and analyzed this heart rate response using heart rate variability analysis. Both cold and warm septic pigs were profoundly hypotensive but not significantly different.…”

Blood biochemical changes in pigs after infusion with acetate-buffered or lactate-buffered crystalloid solutions

“…Many studies have also used LRS to replace fluids in pigs modeling hemorrhage, resuscitation, trauma and combinations thereof [15][16][17][18][19] , and more recent research has used EMI while investigating inhalational anesthetics in goats and pigs and hypothermia in pigs 20,21 . Juvenile pigs are frequently used in preclinical studies for a wide range of conditions, including cardiovascular and resuscitation medicine, osteology and bone repair, trauma, shock, hernia repair, skin grafting, allergic skin diseases and burns [22][23][24][25][26][27][28][29] .…”