Mild Cognitive Impairment in General Practice: Age-Specific Prevalence and Correlate Results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)

Luck, Tobias; Riedel‐Heller, Steffi G.; Kaduszkiewicz, Hanna; Bickel, Horst; Jessen, Frank; Pentzek, Michael; Wiese, Birgitt; Koelsch, Heike; Bussche, Hendrik van den; Abholz, Heinz Harald; Moesch, Edelgard; Gorfer, Sandra; Angermeyer, Matthias C.; Maier, Wolfgang; Weyerer, Siegfried

doi:10.1159/000108099

Cited by 172 publications

(153 citation statements)

References 66 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…15 The aim was for each study centre to recruit 20 primary care practices with 25 patients. In each practice 50 randomly selected patients from those eligible were invited to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Determinants of health-related quality of life in older primary care patients: results of the longitudinal observational AgeCoDe Study

Eisele¹,

Kaduszkiewicz²,

König³

et al. 2015

Br J Gen Pract

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Determinants of health-related quality of life in older primary care patients: results of the longitudinal observational AgeCoDe Study

Eisele¹,

Kaduszkiewicz²,

König³

et al. 2015

Br J Gen Pract

Self Cite

View full text Add to dashboard Cite

“…1,2 Several factors are important for the onset of CI and CD, including female sex and the apolipoprotein Eε4 (apoEε4) genotype. 3,4 Changes in blood pressure (BP) are associated with both CI and CD in older people. 5,6 Hypertension might be implicated in the pathogenesis of poor cognition, 7 and recent studies suggest that hypotension could be a risk factor for CI and CD too.…”

mentioning

confidence: 99%

Orthostatic Changes in Blood Pressure and Cognitive Status in the Elderly

et al. 2016

View full text Add to dashboard Cite

Abstract-We studied a cohort of 1408 older subjects to explore whether postural changes in blood pressure (BP; defined as orthostatic hypo-or hypertension) can predict the onset of cognitive deterioration. Orthostatic hypotension was defined as a drop of 20 mm Hg in systolic or 10 mm Hg in diastolic BP and orthostatic hypertension as a rise of 20 mm Hg in systolic BP. Orthostatic BP values were grouped into quintiles for secondary analyses. Two cognitive assessments were considered:(1) cognitive impairment, that is, Mini-Mental State Examination scores ≤24/30, and (2) cognitive decline (CD), that is, a 3-point decrease in Mini-Mental State Examination score from the baseline to the follow-up. At the baseline, the prevalence of orthostatic hypotension and hypertension was 18.3% and 10.9%, respectively. At the follow-up (4.4±1.2 years), 286 participants were found cognitively impaired and 138 had a CD. Using logistic regression analysis adjusted for potential baseline confounders, participants with orthostatic hypertension were at significantly higher risk of CD (odds ratio =1.50; 95% confidence intervals =1.26-1.78). Neither orthostatic hypotension nor orthostatic hypertension raised the risk of developing a cognitive impairment. Using quintiles of orthostatic BP values, we found that both decreases and increases in systolic and diastolic BP raised the risk of CD, but not of cognitive impairment. In conclusion, we found that orthostatic hypertension predicts the onset of CD, but not of cognitive impairment in the elderly, whereas orthostatic hypotension predicts neither of these conditions. Further studies are needed to confirm our findings. Correspondence to Nicola Veronese, Department of Medicine-DIMED, Geriatrics Division, University of Padova, Via Giustiniani, 2-35128, Padova, Italy. E-mail ilmannato@gmail.com or Chiara Curreri, Department of Medicine-DIMED, Geriatrics Division, University of Padova, Via Giustiniani, 2-35128 Padova, Italy. E-mail chiaracurreri@icloud.com Orthostatic Changes in Blood Pressure and Cognitive Status in the ElderlyThe Progetto Veneto Anziani Study Methods Data Source and SubjectsThis work was based on data obtained for the Progetto Veneto Anziani (Pro.V.A.) study, an observational cohort study of communitydwelling subjects aged ≥65 years residing in Camposampiero and Rovigo (2 towns in northern Italy), who were enrolled without any specific exclusion criteria. 16 Baseline visits were conducted between October 1995 and November 1997. To avoid any sampling bias, the initial sample was randomly divided into 3 (Camposampiero) and 4 (Rovigo) mutually exclusive subsets that were balanced for age and sex distribution. A random sample was selected from the first subset, and the remaining subsets were set aside. As part of the sampling strategy, age and sex were stratified to maintain a male-to-female ratio of 2:3, to oversample the oldest subjects and thereby obtain reliable estimates of conditions with low prevalence rates, and to recruit a sizable proportion of disabled individuals. Th...

show abstract

“…In addition, rs75935628 was also genotyped in the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe) case-control samples. [15][16][17] Furthermore, rs75932628 genotypes were imputed in 3 publicly available GWAS datasets, GlaxoSmithKline (GSK), the Alzheimer's Disease Neuroimaging Initiative (ADNI), and the Translational Genomics Research Institute series 2 (TGEN2), which were not analyzed in the previous studies.…”

mentioning

confidence: 99%

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

et al. 2014

View full text Add to dashboard Cite

Objectives: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H), in exon 2 of the gene encoding the "triggering receptor expressed on myeloid cells 2" (TREM2) significantly increases the risk of Alzheimer disease (AD) with an effect size comparable to that of the APOE e4 allele. Methods:In this study, we attempted to replicate the association between rs75932628 and AD risk by directly genotyping rs75932628 in 2 independent Caucasian family cohorts consisting of 927 families (with 1,777 affected and 1,235 unaffected) and in 2 Caucasian case-control cohorts composed of 1,314 cases and 1,609 controls. In addition, we imputed genotypes in 3 independent Caucasian case-control cohorts containing 1,906 cases and 1,503 controls.Results: Meta-analysis of the 2 family-based and the 5 case-control cohorts yielded a p value of 0.0029, while the overall summary estimate (using case-control data only) resulted in an odds ratio of 1.67 (95% confidence interval 0.95-2.92) for the association between the TREM2 R47H and increased AD risk.Conclusions: While our results serve to confirm the association between R47H and risk of AD, the observed effect on risk was substantially smaller than that previously reported. Neurology ®

show abstract

Mild Cognitive Impairment in General Practice: Age-Specific Prevalence and Correlate Results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)

Cited by 172 publications

References 66 publications

Determinants of health-related quality of life in older primary care patients: results of the longitudinal observational AgeCoDe Study

Determinants of health-related quality of life in older primary care patients: results of the longitudinal observational AgeCoDe Study

Orthostatic Changes in Blood Pressure and Cognitive Status in the Elderly

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

Contact Info

Product

Resources

About