Mild cognitive impairment

Busse, Anja; Hensel, Anke; Gühne, Uta; Mc, Angermeyer; Riedel‐Heller, Steffi G.

doi:10.1212/01.wnl.0000249117.23318.e1

Cited by 506 publications

(468 citation statements)

References 26 publications

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“…Petersen et al (1999) suggests a cutoff of 1.5 SD below the mean to designate memory impairment. Busse et al (2006) reported cutoff scores at 1 SD below the mean were more sensitive in detecting subjects who later converted to AD. It is possible that adjusting the cutoff thresholds might improve the ability to detect early memory changes in subjects with high cognitive reserve.…”

Section: Dm Rentz Et Almentioning

confidence: 96%

Intelligence quotient–adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion

Rentz

Huh

Sardinha

et al. 2007

J. Inter. Neuropsych. Soc.

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Cognitive reserve among highly intelligent older individuals makes detection of early Alzheimer's disease (AD) difficult. We tested the hypothesis that mild memory impairment determined by IQ-adjusted norms is associated with single photon emission computed tomography (SPECT) perfusion abnormality at baseline and predictive of future decline. Twenty-three subjects with a Clinical Dementia Rating (CDR) score of 0, were reclassified after scores were adjusted for IQ into two groups, 10 as having mild memory impairments for ability (IQ-MI) and 13 as memory-normal (IQ-MN). Subjects underwent cognitive and functional assessments at baseline and annual follow-up for 3 years. Perfusion SPECT was acquired at baseline. At follow-up, the IQ-MI subjects demonstrated decline in memory, visuospatial processing, and phonemic fluency, and 6 of 10 had progressed to a CDR of 0.5, while the IQ-MN subjects did not show decline. The IQ-MI group had significantly lower perfusion than the IQ-MN group in parietal0precuneus, temporal, and opercular frontal regions. In contrast, higher perfusion was observed in IQ-MI compared with IQ-MN in the left medial frontal and rostral anterior cingulate regions. IQ-adjusted memory impairment in individuals with high cognitive reserve is associated with baseline SPECT abnormality in a pattern consistent with prodromal AD and predicts subsequent cognitive and functional decline. (JINS, 2007, 13, 821-831.)

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Section: Dm Rentz Et Almentioning

confidence: 96%

Intelligence quotient–adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion

Rentz

Huh

Sardinha

et al. 2007

J. Inter. Neuropsych. Soc.

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“…Research on MCI has received much attention in the past decade as researchers and clinicians have pushed for early identification and treatment of dementia. Current research suggests that older adults with MCI are more likely to progress to dementia than their counterparts without MCI (Albert, Blacker, Moss, Tanzi, & McArdle, 2007;Busse, Hensel, Gühne, Angermeyer, & Riedel-Heller, 2006;Landau et al, 2010;Petersen et al, 2001). Petersen and colleagues (2001) reported that most MCI subjects with memory impairment progressed to Alzheimer's disease at a rate of 10% to 15% per annum, in comparison to those healthy controls whose progressed a rate was 1% to 2 %.…”

Section: Introductionmentioning

confidence: 99%

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Lam

Yiend

Lee

2017

NRE

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“…Siguiendo esta lógica, a partir de la concreción de un consenso diagnóstico internacional, se ha podido dividir el DCL en diversos subgrupos en función del número y tipo de dominios cognitivos afectados, si bien existen discrepancias en los estudios en cuanto a su número (Busse, Hensel, Günhe, Angermeyer y Riedel-Heller, 2006;…”

Section: Introductionunclassified

“…La solución a esta problemática llegó con la adopción internacional de los criterios establecidos por Petersen para el DCL (Petersen, Doody, Kurz, Mohs, Morris y Rabins, 2001). Estos se definen a partir de la observación, durante al menos seis meses, de los siguientes síntomas: a) quejas subjetivas de memoria, preferiblemente reveladas por informadores fiables; b) quejas subjetivas de una o varias áreas cognitivas, preferiblemente reveladas por informadores fiables; c) deterioro cognitivo, en memoria o algún otro dominio cognitivo, de al menos 1.5 DT por debajo de la media para el grupo etario y educativo pertinente; d) actividades de la vida diaria preservadas (el paciente puede, no obstante, presentar dificultades en las actividades complejas del día a día) y e) ausencia de demencia.Siguiendo esta lógica, a partir de la concreción de un consenso diagnóstico internacional, se ha podido dividir el DCL en diversos subgrupos en función del número y tipo de dominios cognitivos afectados, si bien existen discrepancias en los estudios en cuanto a su número (Busse, Hensel, Günhe, Angermeyer y Riedel-Heller, 2006; …”

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Mild cognitive impairment: classification method and procedure

2012

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Resumen: El deterioro cognitivo leve (DCL) se presenta como una de las entidades clínicas que mayor interés despierta en el ámbito de la neurociencia cognitiva, por la dimensión de sus cifras y la posible evolución de algunos de los subtipos a demencia. Este trabajo tiene como objetivo poner a prueba un método y procedimiento de clasificación del DCL en función de las puntuaciones en las pruebas neuropsicológicas y de su convergencia con un criterio clínico establecido, así como analizar las diferencias entre los grupos resultantes. Tras la aplicación de los criterios de inclusión-exclusión, se evaluó mediante una batería de pruebas neuropsicológicas a 39 personas con edades entre 60 y 89 años. Se establecieron grupos de diagnóstico mediante un criterio psicométrico y un análisis de conglomerados, obteniéndose resultados satisfactorios al analizar la coherencia entre ambos criterios. Destaca la importante cantidad de sujetos con diagnóstico de DCL (43.6% y 53.9% en función de cada uno de los criterios), observándose en éstos un menor nivel de escolarización que los sujetos sanos. Es necesaria la prevención del DCL y la definición de los subtipos, además, el uso de criterios objetivos, con rigor científico y que evalúen diferentes dominios cognitivos, se muestra como un adecuado mecanismo para su análisis y diagnóstico. Palabras clave: deterioro cognitivo leve; envejecimiento; clasificación; diagnóstico; evaluación neuropsicológica.Title: Mild cognitive impairment: classification method and procedure. Abstract: Mild cognitive impairment (MCI) is one of the most important clinical entities in the field of cognitive neuroscience, the size of their numbers and the possible evolution of some of the subtypes of dementia. The aim of this study is to test a method and procedure for classification of MCI in terms of neuropsychological test scores and its convergence with established clinical criteria, and analyze the differences between the resulting groups. After applying the inclusion-exclusion criteria, was assessed using a battery of neuropsychological tests to 39 people aged between 60 and 89 years. Diagnostic groups were established by psychometric criteria and a cluster analysis and satisfactory results were obtained by analyzing the coherence between the two criteria. There is a significant number of subjects diagnosed with MCI (43.6% and 53.9% as a function of each criterion), showing them lower levels of schooling than healthy controls. MCI prevention and the definition of subtypes is necessary, although the use of criteria: objective, scientifically valid and assess different cognitive domains, is an appropriate mechanism to be analysis and diagnosis. Key words: mild cognitive impairment; aging; classification, diagnosis, neuropsychological assessment. IntroducciónEl proceso de envejecimiento conlleva una serie de modificaciones morfológicas, fisiológicas, sociales y psicológicas que son consecuencia directa del paso del tiempo, si bien se manifiestan en formas y momentos dispares en cada individuo. De entre e...

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Mild cognitive impairment

Abstract: It has been assumed that each MCI subtype is associated with an increased risk for a particular type of dementia. We can only partially agree with this.

Cited by 506 publications

References 26 publications

Intelligence quotient–adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion

Intelligence quotient–adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Mild cognitive impairment: classification method and procedure

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