Mild Cognitive Impairment and Depressive Symptoms in Elderly Patients with Diabetes: Prevalence, Risk Factors, and Comorbidity

Abstract

The aim of the study was to estimate the prevalence of mild cognitive impairment (MCI), depressive syndrome cases, and its comorbidity, and to identify predictors of these conditions. Methods. 276 diabetics elders were screened for MCI and depressive symptoms. Detailed information of history of diabetes, and data of BMI, HbA1c, and blood lipids were collected. Results. The prevalence of MCI was 31.5%, depressive syndrome was 29.7%, and MCI with coexisting depressive mood was 9.1%. The logistic regression analysis revealed that variables which increased the likelihood of having been diagnosed with MCI were: higher HbA1c level, previous CVD, hypertension, retinopathy, increased number of comorbidities, and less years of formal education. Significant predictors of having a depressive mood included female gender, single marital status, current and past smoking status, lack of physical activity, higher BMI and total cholesterol level, increased number of comorbidities, history of hypoglycemia, and insulin treatment. Factors associated with both MCI and depressive syndrome were female gender, single marital status, past smoking status, retinopathy, previous CVD or stroke, increased number of comorbidities, and insulin treatment. Conclusions. Depressive symptoms, MCI, and its comorbidity are common in elderly subjects with type 2 diabetes. Systematic screening could result in the identification of high-risk patients.

Cognitive Impairment in Advanced Chronic Kidney Disease: The Canadian Frailty Observation and Interventions Trial

“…Studies in patients with type 2 diabetes detected MCI in about one third of participants through cognitive screening and an assessment of activities of daily living (ADL) and instrumental ADL [29,30] . Finally, multiple studies have assessed cognition in patients with CHF.…”

Ghrelin Levels in Elderly, Diabetic Patients with Mild Cognitive Impairment

“…Higher levels of HbA1c, diagnosis of CVD and hypertension, increased number of co-morbidities and less years of education -all these factor are proven to contribute to cognitive impairment in diabetes [1,6]. Decreased ghrelin levels could be another predictor of diagnosis of MCI in elderly diabetic population.…”

“…There is a high prevalence of mild cognitive impairment (MCI) in individuals with type 2 diabetes mellitus (T2DM) [1,2]. A meta-analysis of longitudinal studies reported that individuals with diabetes had 1.21-fold significantly increased odds of having Alzheimer's disease, 1.51-fold higher risk for any dementia and 1.21 higher risk for mild cognitive impairment compared to non-diabetic individuals [3].…”

“…Recently, some researchers have suggested a potential role for ghrelin in cognitive dysfunction Ghrelin Levels in Elderly, Diabetic Patients with Mild Cognitive Impairment 276 participants were recruited from the study previously described elsewhere [1].…”

Asociación entre actividad física y auto-percepción de pérdida de la memoria

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