MIL‐53(Fe) Metal–Organic Frameworks (MOFs) as an Efficient and Reusable Catalyst for the One‐Pot Four‐Component Synthesis of Pyrano[2,3‐c]‐pyrazoles

Abstract

A novel and simple approach for the efficient and rapid synthesis of pyrano[2,3-c]-pyrazoleshas been accomplished via the four-component condensation reaction of malononitrile, hydrazine hydrate, ethyl acetoacetate, and substituted aldehydes using MIL-53(Fe) metal-organic framework (MOF) as a catalyst in ethanol at room temperature. Recycling studies have shown that the MIL-53(Fe) can be readily recovered and reused six times without significant loss of its activity. The present protocol offers the advantages including short reaction times, simple workup, high yields, elimination of toxic solvents, no chromatographic purification and recoverability of the catalyst. Also, the catalyst was fully characterized by SEM, EDX, FT-IR, XRD, TGA and TEM analysis.

Introduction of a Novel Brønsted Acidic Ionic Liquid Incorporated in UiO‐66 Nanocages for the Efficient Synthesis of Pyrimido[4,5‐d]Pyrimidines

“…We have recently reported various synthetic approaches for several biologically interesting products by the use of nanocatalysts …”

Hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework composite: a novel and versatile tool for the preparation of pyrido[2,3-d:5,6-d′]dipyrimidines

“…Recently, we have reported various synthetic methods for the preparation of several heterocycle compounds using nanocatalysts. [32][33][34][35][36] In experimental and industrial research, it is essential to decrease toxic waste and reaction process time to protect the environment.…”

Pd(0)‐guanidine@MCM‐41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes

“…Pyrazoles or pyrazolones [e.g. bis (pyrazolyl)methanes] are a significant category of bioactive drug goals in the pharmaceutical industry that show a variety of biological and medicinal activities, such as anti‐HIV, antiviral, gastric secretion stimulatory, antifilarial, antioxidant, antihypertensive, anticancer, anti‐inflammatory, antimalarial, antidepressant, antimicrobial, antipyretic and antibacterial properties. There are two ways to prepare bis (pyrazolyl)methanes: (i) the one‐pot pseudo five‐component reaction among phenylhydrazine, ethyl acetoacetate and aromatic aldehydes; and (ii) the one‐pot pseudo three‐component reaction between 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐one and aromatic aldehydes.…”