Migration of chick blastoderm under the vitelline membrane: The role of fibronectin

Lash, James W.; Gosfield, E; Ostrovsky, David; Bellairs, Ruth

doi:10.1016/0012-1606(90)90309-7

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…This peptide-induced blebbing differs in both shape and causation from that reported by others (compare Erickson and Trinkaus, 1976;Yamada et al, 1976). The peptide-induced blebs are reversibly evoked by a specific agent (compare Lash et al, 1987Lash et al, , 1990. One possibility is that integrin receptors on cell processes are blocked by the peptides, resulting in detachment from the substratum and the formation of blebs (compare Akiyama et al, 1985;Linask and Lash, 1990).…”

Section: Discussionmentioning

confidence: 68%

“…One possibility is that integrin receptors on cell processes are blocked by the peptides, resulting in detachment from the substratum and the formation of blebs (compare Akiyama et al, 1985;Linask and Lash, 1990). In fact, Lash et al (1990) showed that there was a direct temporal correlation between the presence of GRGDS and the withdrawal of cell processes during the migration of chick blastoderm cells. An alternative interpretation is that generally decreased adhesion to the substratum leads to cell rounding and excess membrane, which then becomes blebs or microvilli (Yamada et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

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Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Bellairs

Lear

Yamada

et al. 1995

Developmental Dynamics

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Bellairs

Lear

Yamada

et al. 1995

Developmental Dynamics

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“…Tschudi et al 1985). Recently, Lash et al (1990) have shown that fibronectin plays an important role in the attachment and migration of the cells of the margin of overgrowth on the vitelline membrane. During formation of the blastula the edge cells of the AO are round and not yet attached to the vitelline membrane, and no gold staining was found around their surface (Fig.…”

Section: Cell Migration and Axialization Of The Embryomentioning

confidence: 99%

Fibronectin distribution in the chick embryo during formation of the blastula

et al. 1991

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The distribution of the fibronectin-rich extracellular matrix (ECM) in the chick embryo during formation of the blastula has been evaluated semiquantitatively using an electron microscopical immunogold staining technique. During the first 10 h of postlaying development, fibronectin was found in both embryonic area pellucida and extra-embryonic area opaca of the blastoderm. In the area pellucida, the fibronectin was (1) associated with the basal lamina of the epiblast, (2) present between epiblastic and hypoblastic cells and (3) occasionally internalized in hypoblastic cells. Along the embryonic axis, a transient and high density of ECM was associated with the front of the anteriorly and rapidly expanding hypoblast. Very high density of fibronectin was observed in the marginal zone of the area pellucida, where the epiblastic and deeper cell layers show contacts and intense re-arrangements. In the area opaca, fibronectin was at first found only sporadically between contacting cells, but its density increased steadily and markedly during the first day of development. These rapid and significant changes in the regional distribution of fibronectin-rich ECM are discussed with respect to the early morphogenesis of the chick embryo.

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“…Its role in these circumstances appears to be to promote the attachment of the migrating cells to the underlying substratum. Examples in the chick embryo include the migration of the neural crest cells (Boucaut et al 1984;Bronner-Fraser 1985) of the precardiac mesoderm cells which migrate toward a region of increasing fibronectin concentration in a haptotactic manner (Linask and Lash 1986) and of the edge cells of the blastoderm beneath the vitelline membrane (Lash et al 1990). …”

Section: Discussionmentioning

confidence: 99%

“…The bleb-like effect is probably due to the contraction of cell processes; we have shown elsewhere that there is rapid withdrawal of the cell processes in edge cells of the chick blastoderm treated with GRGDS (Lash et al 1990). It is of interest that in the present experiments this phenomenon of rounded cell processes was still retained in specimens fixed at 21 h, which had apparently "escaped" from the effect of the peptide.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the involvement of receptors for fibronectin in the promotion of chick tail segmentation

et al. 1990

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In the chick embryo the paraxial mesoderm forms about 50-53 pairs of somites, the precise number depending on the extent to which segmentation proceeds along the tail. However, the terminal mesoderm of the tail fails to segment despite the fact that it appears to contain a reservoir of potential somites. Why does this mesoderm not segment? Some clues can be obtained by comparing this non-segmenting region with the segmental plate in the trunk. We and others have shown that in the trunk region of the chick, cell adhesion plays a major role in somitogenesis and that this increased cell adhesion is associated with compaction of segments of mesoderm immediately prior to segmentation. This compaction can be brought about prematurely by fibronectin and by the specific adhesion peptide GRGDS. The terminal mesoderm in the tail resembles the segmental plate mesoderm in the trunk in undergoing compaction in response to fibronectin and GRGDS. The tail mesoderm differs from the segmental plate mesoderm in that it can also respond to peptides closely related to GRGDS. The response suggests that, whereas the integrin receptors for fibronectin and GRGDS appear to be specific in the presomitic trunk mesoderm, responding only to the specific adhesion-peptide GRGDS, the tail mesoderm may contain more heterogeneous sets of receptors within the integrin/VLA family that respond to a wider variety of ligands. Coincident with these differences is the phenomenon of regional cell death in the tail bud mesoderm. All of these factors are thought to play a role in the extent of segmentation in the paraxial mesoderm of the embryonic chick.

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Migration of chick blastoderm under the vitelline membrane: The role of fibronectin

Cited by 17 publications

References 24 publications

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Posterior extension of the chick nephric (Wolffian) duct: The role of fibronectin and NCAM polysialic acid

Fibronectin distribution in the chick embryo during formation of the blastula

Evidence for the involvement of receptors for fibronectin in the promotion of chick tail segmentation

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