Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti‐<scp>NR</scp>2 or anti‐P antibodies

Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Hirohata, Shunsei; Beyer, Mona K.; Greve, Ole Jacob; Kvivik, Ingeborg; Kvaløy, Jan Terje; Harboe, Erna; Gøransson, Lasse Gunnar; Omdal, Roald

doi:10.1111/ene.12946

Cited by 10 publications

(7 citation statements)

References 29 publications

(33 reference statements)

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“…Neuroimaging studies based on MRI [ 184 , 185 ], H1-Magnetic resonance spectroscopy [ 186 ] and single-photon emission computed tomography [ 187 , 188 ] have been also performed in order to identify the anatomic and functional correlates underlying the possible association between SLE and headache. Unfortunately, these studies were not able to definitely clarify this issue due to the small sample size and in some cases the lack of a control group [ 188 ].…”

Section: Headache and Connectivitismentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly, several genetic and environmental pathogenic factors seem to be frequently shared by headache and immunological/autoimmune diseases. Accordingly, immunological alterations in primary headaches, in particular in migraine, have been suggested to predispose some patients to the development of immunological and autoimmune diseases. On the other hand, pathogenic mechanisms underlying autoimmune disorders, in some cases, seem to favour the onset of headache. Therefore, an association between headache and immunological/autoimmune disorders has been thoroughly investigated in the last years. The knowledge of this possible association may have relevant implications in the clinical practice when deciding diagnostic and therapeutic approaches. The present review summarizes findings to date regarding the plausible relationship between headache and immunological/autoimmune disorders, starting from a description of immunological alteration of primary headaches, and moving onward to the evidence supporting a potential link between headache and each specific autoimmune/immunological disease.

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Section: Headache and Connectivitismentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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“…In total, 17 studies with data on anti-NR2A/B antibodies in 2,212 SLE patients, 99 patients with other autoimmune diseases (e.g., antiphospholipid syndrome, myasthenia gravis, and autoimmune polyendocrine syndrome I) and 538 healthy controls were included. Overall pooled prevalence of serum/plasma anti-NR2A/B antibodies was higher in SLE patients [24.6% (95% CI 18.5–32.0%)] compared to other autoimmune diseases [14.8% (95% CI 2.2-56.9)] and healthy controls [7.6% (95% CI 4.6–12.4%)] ( p = 0.001) (40). SLE patients with NP syndromes had more frequently NR2A/B antibodies [pooled OR = 1.607 (95% CI 1.041–2.479), p = 0.032] as compared to SLE without NP syndromes.…”

Section: Studies Applying Acr Criteriamentioning

confidence: 99%

Definition of NPSLE: Does the ACR Nomenclature Still Hold?

et al. 2018

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Systemic lupus erythematosus (SLE) patients have frequently neuropsychiatric manifestations. From the first description of coma in 1875, a variety of manifestations has been described to occur in SLE. However, the lack of standardization reduced the comparability of published studies. In 1999, the American College of Rheumatology published guidelines to define neuropsychiatric nomenclature in SLE. This was the first step toward uniform diagnostic criteria. Several studies have been published since then applying the ACR criteria and frequencies of different manifestations can now be compared between cohorts. Although these criteria are diagnostic, therapeutic approach to different manifestations varies according to nature and severity of the manifestations. Herby, we will review the different definition for NPSLE published, and determine advantages and limitation.

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“…Differential prevalence of migraine in SLE patients has been reported from various populations ranges from 6.82% to 66.09%. Furthermore, some studies reported a higher frequency of migraine in SLE patients compared to healthy controls, 9,[11][12][13][14]17,18,23 while others remained comparable. 8,10,15,16 The differential frequency of migraine in various populations and while comparing patients and controls may be attributed to smaller sample size, ethnicity of the enrolled patients or geographical location, and other confounding factors of migraine.…”

Section: Introductionmentioning

confidence: 95%

Prevalence of migraine in systemic lupus erythematosus: A meta-analysis

Sarangi

Nahak

Rupashree³

et al. 2023

Lupus

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Background Systemic lupus erythematosus (SLE) is an autoimmune disorder with a wide range of clinical manifestations, including neurological issues in about 25%–75% of cases. Among the neurological involvement cases, most cases show migraine. However, the prevalence of migraine varied worldwide, and in some studies, a higher incidence of migraine in SLE cases was reported compared to healthy controls. In the present study, we adopted a meta-analysis approach to find out the prevalence of migraine in SLE patients worldwide and investigate whether migraine frequency is more prevalent in SLE patients than controls. Material and methods Various literature databases such as Scopus, PubMed, Science Direct, and Google Scholar were screened for eligible studies. The last search was performed on January 21, 2023. Publication biases were accessed by Egger’s regression analysis and funnel plots. Cochrane Q statistics and I2 values explored the presence or absence of heterogeneity. All statistical analysis of meta-analysis was performed in comprehensive meta-analysis software v3. Results Based on predefined inclusion and exclusion criteria, 17 reports comprising 2901 SLE patients and 575 healthy controls were considered in the present study. The meta-analysis revealed the prevalence of migraine to be 34.8%. Furthermore, migraine was more prevalent in SLE patients than healthy controls (OR: 1.964, p = 0.000, 95% CI = 1.512–2.550). Similar trends were also observed while considering another 10 independent reports those were not disclosed about the migraine diagnosis criteria (number of reports: 27, SLE: 3473, HC: 741, prevalence: 33.5%, SLE vs HC: OR = 2.107, p = 0.000, 95% CI = 1.672–2.655). Subgroup analysis demonstrated that SLE patients from South America had a higher prevalence of migraine (56.2%). Conclusions About one-third of SLE patients experience migraine worldwide. The prevalence of migraine is more frequent in SLE patients than the healthy controls.

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Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti‐NR2 or anti‐P antibodies

Cited by 10 publications

References 29 publications

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Definition of NPSLE: Does the ACR Nomenclature Still Hold?

Prevalence of migraine in systemic lupus erythematosus: A meta-analysis

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