Migraine Headaches and Mood/Anxiety Disorders in the ELSA Brazil

Abstract

The increase in migraine frequency was associated with progressively higher frequencies of having mood/anxiety disorders in all samples suggesting for some psychiatric disorders a likely dose-response effect especially for women.

Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta‐Analysis

“…Another potential confounder is concomitant medication use, particularly in the migraine no‐triptans group. Some of these medications are known to be associated with preterm birth, and depression in particular is often present in patients suffering from migraines …”

Associations Between Migraine and the Most Common Psychiatric Co‐Morbidities

“…There does not appear to be significant evidence of an independent relationship between migraine and obsessive‐compulsive disorder (OCD). Goulart et al reported an adjusted odds ratio of 4.16 (1.97‐8.78) for migraine with daily headache in subjects with OCD, similar to their findings in GAD. They also assessed headache frequency and found that the relationship between OCD and migraine was significant only in the daily headache group for male subjects.…”

“…Louter et al suggested that greater migraine attack frequency was associated with an increased prevalence of depression. In a prospective study by Goulart et al, subjects were categorized by headache frequency, and found that the adjusted odds ratio of migraine with daily headache was 6.94 (4.20‐11.49) in subjects with major depressive disorder (MDD) compared to controls. This is in contrast to an odds ratio of migraine with less than monthly headaches of 2.14 (1.33‐3.43) in subjects with MDD.…”

“…Hamelsky and Lipton reported an odds ratio of 3.5‐5.3 for GAD in migraine. Goulart et al reported an adjusted odds ratio for migraine with daily headache of 4.04 (95%CI 2.64‐6.19) in subjects with GAD. They also assessed patients with panic disorder, and did not find a significant relationship, with an adjusted odds ratio for migraine with daily headache of 2.28 (95%CI 0.66‐7.86) in these subjects.…”

Migraine and its psychiatric comorbidities

“…Patients with OCD are at increased risk and higher frequency of migraine (OR 4.57, 95% CI 2.82 to 7.83 for migraine 2–6 times/week) 24. The OR of PD in migraine is 3.76, and is even greater in patients with migraine with aura 25.…”