Migraine, daily chronic headache and fibromyalgia in the same patient: an evolutive ?continuum? of non organic chronic pain? About 100 clinical cases

Centonze, Vincenzo; Bassi, Abhinav; Cassiano, M.; Munno, I; Dalfino, L.; Causarano, V.

doi:10.1007/s10072-004-0314-4

Cited by 28 publications

(19 citation statements)

References 2 publications

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“…For this reason, we investigated the incidence of fibromyalgia in our study cohort and found none. There is a very high incidence (53‐82%) of headache among fibromyalgia patients, which is reportedly either migraine or tension‐type headaches 18,19 . Conversely, 24‐48% of headache patients also have fibromyalgia 20 .…”

Section: Resultsmentioning

confidence: 99%

Occipital Neuralgia With and Without Migraine: Difference in Pain Characteristics and Risk Factors

Sahai‐Srivastava

Zheng

2010

Headache

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There may be significant differences in pain characteristics for patients with ON + M and those for patients with isolated ON. The data indicate that patients with migraine should also be screened for symptoms of ON, as there may be similarities in presentation. The clinical implications of distinguishing ON + M and isolated ON include differences in treatment regimen, avoidance of inappropriate use of medical resources, and differences in long-term outcomes.

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Section: Resultsmentioning

confidence: 99%

Occipital Neuralgia With and Without Migraine: Difference in Pain Characteristics and Risk Factors

Sahai‐Srivastava

Zheng

2010

Headache

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“…Fibromyalgia is observed in 22-36% of migraine patients (10,19). It has been hypothesized that episodic migraine and fibromyalgia belong to the same disorder (19,20) and that a common mechanism underlies the widespread hypersensitivity in fibromyalgia and migraine patients. Cephalic and extracephalic allodynia exhibit different features, with the former being mostly mechanical (92% of patients) and the latter thermal (75% of patients).…”

Section: Discussionmentioning

confidence: 99%

Are there differences between cephalic and extracephalic cutaneous allodynia in migraine patients?

et al. 2009

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Cutaneous allodynia (CA), pain in response to innocuous cutaneous stimuli, is recognized as a sign of central sensitization during migraine episodes. It is either restricted within the pain area on the ipsilateral head, or extends within and outside the head. Moreover, CA can be elicited in response to thermal (heat or cold) and/or mechanical stimuli. This raises the question as to whether cephalic and extracephalic CAs share the same properties. We assessed cephalic and extracephalic CAs in migraine episodic patients using a questionnaire completed at home during migraine attacks. A total of 67 episodic migraine patients (58 women, nine men; 4013 years old) addressed all questions in the questionnaire. Forty-nine patients (73%) cited one or more allodynic symptoms during or immediately after the migraine attack. Almost all 49 patients reported cephalic CA, whereas 24 (49%) also reported extracephalic CA. Occurrence and extension of CA correlated (P = 0.005) with headache intensity. Modalities of cephalic and extracephalic CA were different (chi2 = 12.03; P = 0.002), extracephalic CA being mostly thermal (75%) whereas cephalic CA was mostly mechanical (92%). This suggests that cephalic and extracephalic CAs involve different mechanisms.

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“…Common genetic basis, synergetically working with other factors (emotional, personality features, stressful events and medication overuse) should cause a chronic antinociceptive system alteration and therefore a progressive increase (hyperalgesia) and diffusion (panalgesia) of pain. It has been hypothesized that episodic migraine, chronic daily headaches and FM may actually be a continuum of the same disorder [5].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement

et al. 2012

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BackgroundFibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and migraine. Recent studies have shown some evidences demonstrating that oxidative stress is associated to clinical symptoms in FM of fibromyalgia. We examined oxidative stress and bioenergetic status in blood mononuclear cells (BMCs) and its association to headache symptoms in FM patients. The effects of oral coenzyme Q10 (CoQ10) supplementation on biochemical markers and clinical improvement were also evaluated.MethodsWe studied 20 FM patients and 15 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Headache Impact Test (HIT-6). Oxidative stress was determined by measuring CoQ10, catalase and lipid peroxidation (LPO) levels in BMCs. Bioenergetic status was assessed by measuring ATP levels in BMCs.ResultsWe found decreased CoQ10, catalase and ATP levels in BMCs from FM patients as compared to normal control (P<0.05 and P<0.001, respectively) We also found increased level of LPO in BMCs from FM patients as compared to normal control (P<0.001). Significant negative correlations between CoQ10 or catalase levels in BMCs and headache parameters were observed (r = −0.59, P<0.05; r = −0.68, P<0.05, respectively). Furthermore, LPO levels showed a significant positive correlation with HIT-6 (r = 0.33, P<0.05). Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical and headache symptoms (P<0.001).DiscussionThe results of this study suggest a role for mitochondrial dysfunction and oxidative stress in the headache symptoms associated with FM. CoQ10 supplementation should be examined in a larger placebo controlled trial as a possible treatment in FM.

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Migraine, daily chronic headache and fibromyalgia in the same patient: an evolutive ?continuum? of non organic chronic pain? About 100 clinical cases

Cited by 28 publications

References 2 publications

Occipital Neuralgia With and Without Migraine: Difference in Pain Characteristics and Risk Factors

Occipital Neuralgia With and Without Migraine: Difference in Pain Characteristics and Risk Factors

Are there differences between cephalic and extracephalic cutaneous allodynia in migraine patients?

Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement

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