Migraine and risk of stroke

Øie, Lise Rystad; Kurth, Tobias; Gulati, Sasha; Dodick, David W.

doi:10.1136/jnnp-2018-318254

Cited by 133 publications

(100 citation statements)

References 136 publications

(124 reference statements)

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“…6 ). Migraine is reported to have clinical or pathological relationship with the diseases or disorders which were already discussed in this review article as CNS interstitial fluidopathy which has altered dynamics of ISF/CSF including AD [ 99 ], sleep disorders [ 100 ], ischemic strokes [ 101 ], glaucoma [ 102 ] and Meniere’s disease [ 103 ]. Migraine has an aspect of neuroinflammation, and interstitial space is regarded as one of locations for inflammatory process in migraine [ 104 ].…”

Section: Disorders Categorized In Cns Interstitial Fluidopathiesmentioning

confidence: 99%

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Taoka

Naganawa

2020

Jpn J Radiol

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After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer’s disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose “Central Nervous System (CNS) Interstitial Fluidopathy” as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as “CNS interstitial fluidopathies,” will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for “CNS interstitial fluidopathies.”

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Section: Disorders Categorized In Cns Interstitial Fluidopathiesmentioning

confidence: 99%

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Taoka

Naganawa

2020

Jpn J Radiol

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“…18 Notably, in the above-mentioned group, LDL-C has been associated with vascular events according to a j-shaped pattern, showing the lowest risk for LDL-C values of 84-101 mg/dl (~2.2-2.6 mmol/L). 19 Given this background, in view of the demographical features of migraine and its association with vascular events in younger individuals (<45 years), 20,21 lipid abnormalities may assume an important role regarding the increased vascular risk of patients with migraine (mainly MWA).…”

Section: Introductionmentioning

confidence: 99%

Serum lipid abnormalities in migraine: A meta‐analysis of observational studies

et al. 2021

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Background: The association of migraine with vascular comorbidities is long-established. The contribution of the "traditional" cardiovascular risk factors to this connection remains unclear. Objective: To determine-quantify the differences in the serum lipid concentrations between lipid-lowering agents-naïve individuals with migraine and healthy controls (HC). Methods: The study protocol was not preregistered with an online systematic reviewprotocol registry. A literature search involving MEDLINE, EMBASE, CENTRAL, Google Scholar, and the OpenGrey database was performed. Case-control, cross-sectional, or cohort studies involving HC and participants with migraine (with and without aura regardless of the use of prophylactic treatment) that quantitatively assessed serum low-density lipoprotein cholesterol (LDL-C) (primary index) and/or total cholesterol (TC) and/or high-density lipoprotein cholesterol (HDL-C) and/or triglycerides (TG) (secondary indices) were retrieved. Articles including participants with known dyslipidemia (or under lipid-lowering medications) or with secondary causes of dyslipidemia (aside from the subjectively assessed lifestyle parameters) were excluded. Studies with abstracts and full texts not published in English and articles reporting the implementation of other study designs (reviews, meta-analyses, commentaries, case reports, etc.) were excluded as well. Conference abstracts and English abstracts from studies with full texts not published in English were evaluated as part of the gray literature. Each step of the review process was performed by two investigators independently, and relevant data were abstracted based on standardized extraction forms. Any discrepancies were resolved by a third investigator. Results: Seventeen studies (16 case-control and 1 cross-sectional) fulfilled the eligibility criteria. Retrieved articles involved adult participants, principally during the fourth decade of life. Results were compatible with higher LDL-C levels in migraine individuals

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“… 17 Indeed, migraine with aura is a significant and independent risk factor for ischemic stroke, and there is growing evidence of an association between migraine with aura and other CV disorders, including myocardial infarction, perioperative stroke, hypertension, venous thromboembolism, and atrial fibrillation. 18 - 23 …”

Section: Introductionmentioning

confidence: 99%

Migraine Patients With Cardiovascular Disease and Contraindications: An Analysis of Real-World Claims Data

Dodick

Shewale

Lipton

et al. 2020

J Prim Care Community Health

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Introduction: Triptans, the most commonly prescribed acute treatments for migraine attacks are, per FDA labeling, contraindicated in cardiovascular (CV) disease patients and have warnings and precautions for those with CV risk factors. Methods: Headache specialists, cardiologists, and health economics and outcomes researchers convened to identify diagnostic codes for: (1) CV diseases contraindicating triptans based on FDA labeling; (2) conditions comprising “other significant underlying CV disease”; and (3) CV risk factors included as warnings and precautions for triptans. A retrospective, cross-sectional analysis of commercially insured adult US migraine patients in the 2017 Optum® Clinformatics® Data Mart (CDM) and the 2017 IBM® Watson Health MarketScan® Commercial Claims database was used to estimate the proportion of migraine patients with CV contraindications and warnings and precautions to triptans. Results: Of the 56,662 migraine patients analyzed from Optum CDM, 13.5% had ≥1 CV disease as specified in triptan labeling and an additional 8.5% had ≥1 “other CV disease” judged by the panel to constitute a “significant underlying CV disease” (total: 22.0% migraine patients). Of 176 724 migraine patients analyzed from MarketScan, 12.2% had ≥1 CV disease as specified in the labeling and an additional 8.0% had ≥1 “other significant underlying CV disease” (total: 20.2% of migraine patients). An additional 25.4% and 25.1% of migraine patients had ≥2 CV risk factors in Optum CDM and MarketScan. In total, 47.4% and 45.3% of migraine patients in both databases had a CV disease specified as a contraindication, an “other CV disease” endorsed as significant, or ≥2 CV risk factors identified as warnings and precautions to triptans. Conclusions: Analyses of more than 230,000 people with migraine showed that ≥20% of commercially insured US migraine patients have a CV condition that specifically contraindicates triptan treatment, and an additional 25% have ≥2 CV risk factors identified as warnings and precautions to triptans.

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Migraine and risk of stroke

Cited by 133 publications

References 136 publications

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Serum lipid abnormalities in migraine: A meta‐analysis of observational studies

Migraine Patients With Cardiovascular Disease and Contraindications: An Analysis of Real-World Claims Data

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