Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum

Mehregan, A. H.

doi:10.1001/archderm.107.1.62

Cited by 27 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They share the same histopathology, characterized by non‐palisading granulomatous inflammation and loss of elastica 1 . However, in contrast to actinic granuloma, there were no clear signs of solar elastosis in most cases described as AEGCG and it was also not reported in cases of atypical NL or Miescher's granuloma 24 ,. 25 Besides, elastophagocytosis was not reported in the latter two conditions 24 ,.…”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Özkaya‐Bayazit¹,

Büyükbabanı

Baykal³

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

Annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by phagocytosis of elastic fibres by multinucleated giant cells. Lesions are either solitary or grouped in a few annular patches with elevated borders and central atrophy. Sun-exposed areas are more commonly involved than covered skin. The pathogenesis of the disease is still controversial. We report a 72-year-old fair-skinned woman with unusual clinical findings. An irregularly shaped erythematous plaque covered the entire face, and hundreds of lichenoid papules were present on both sun-exposed and covered areas which gradually evolved into annular lesions of about 0.5-1 cm in diameter. Sparing of an old burn scar and a nearly complete lack of elastic fibres in the scar site were noted, illustrating the presumed importance of dermal elastic tissue in the pathogenesis. The course of the disease is chronic. Several treatments have been tried, with variable success. In our patient, improvement was achieved with chloroquine over a period of 16 weeks.

show abstract

Section: Discussionmentioning

confidence: 81%

“… 25 Besides, elastophagocytosis was not reported in the latter two conditions 24 ,. 25 On the other hand, multiple brownish‐red or flesh coloured papules have been observed in nearly one‐fifth of cases of AEGCG but in none of the cases of actinic granuloma, atypical NL or Miescher's granuloma 23 –25 …”

Section: Discussionmentioning

confidence: 99%

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Özkaya‐Bayazit¹,

Büyükbabanı

Baykal³

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…However, Hanke et al (2) reported that elastosis was not necessarily observed in some cases, and there was no cause-effect relationship between actinic elastosis and granuloma (3,4), so he proposed the more descriptive term "annular elastolytic giant cell granuloma (AEGCG)". AEGCG can be differentiated from granuloma annulare and necrobiosis lipoidica.…”

Section: Discussionmentioning

confidence: 99%

“…Because ring-shaped inflammatory skin lesions are found on sun-exposed areas and elastosis is observed histologically, O'Brien (1) coined the term "actinic granuloma"; he assumed that solar elastosis was a primary causative factor in these skin lesions. However, Hanke et al (2) reported that elastosis was not necessarily observed in some cases, and there was no cause-effect relationship between actinic elastosis and granuloma (3,4), so he proposed the more descriptive term "annular elastolytic giant cell granuloma (AEGCG)". AEGCG can be differentiated from granuloma annulare and necrobiosis lipoidica.…”

Section: Discussionmentioning

confidence: 99%

Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Lesions Arising in Non‐sun‐exposed Areas

Muramatsu

Shirai

Yamashina

et al. 1987

The Journal of Dermatology

View full text Add to dashboard Cite

A 70-year-old man with a 2-year history of annular elastolytic giant cell granuloma associated with diabetes mellitus was reported. The lesions mainly developed in non-sun-exposed areas. Histologic examination revealed phagocytosis of elastic fibers by histiocytic cells. Immunoperoxidase staining for lysozyme disclosed positive reactivity within the cytoplasm of these histiocytic cells. Electron microscopic study also showed elastic fibers and numerous lipid-like substances in the cytoplasm of these cells. These findings indicate high phagocytolytic activity by these infiltrating cells. In our case, actinic damage was not considered to be a primary causative factor, and a possible pathogenesis was also discussed.

show abstract

“…Annular lesions in sun-exposed skin are typical features of AG [4] and annular elastolytic giant cell granuloma (AEGCG) [6]. Miescher's granuloma of the face [7] as well as atypical necrobiosis lipoidica of the face and scalp [8] are nowadays regarded as variants of AG or AEGCG [4]. Non-palisading granulomas, lymphohistiocytic infiltrates and loss of elastic tissue are found in AG and AEGCG.…”

mentioning

confidence: 99%

Sarcoid Variant of Actinic Granuloma: Is It Annular Sarcoidosis?

Gambichler¹,

Herde²,

Hoffmann³

et al. 2001

Dermatology

View full text Add to dashboard Cite

Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum

Cited by 27 publications

References 0 publications

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Lesions Arising in Non‐sun‐exposed Areas

Sarcoid Variant of Actinic Granuloma: Is It Annular Sarcoidosis?

Contact Info

Product

Resources

About