Midtrimester triple test levels in women with severe preeclampsia and HELLP syndrome

Shenhav, Simon; Gemer, Ofer; Volodarsky, Michael; Zohav, Efraim; Segal, Shmuel

doi:10.1034/j.1600-0412.2003.00250.x

Cited by 15 publications

(9 citation statements)

References 20 publications

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“…Progesterone levels are reported to be increased in preclamptic pregnancies [28,29], which are associated with a reduction in subsequent BC, particularly in older primiparas and in the first few years following delivery [12] (Table 1). However, relative to normal pregnancies, those complicated by preclampsia are also typified by decreased levels of estrogens [28,30] and IGF-I [28,31,32], and by elevated levels of androgens [28,30,33,34], IGF binding protein-1 [28,31], hCG [28,[35][36][37] and AFP [37,38] (Table 4). All these factors may act both individually and synergistically to decrease BC risk by reducing proliferative growth of mammary tissue and by inhibiting the malignant transformation of precancerous lesions or the promotion of occult neoplasms [12].…”

Section: Hormonal Factors That Affect Breast Tissue Modifications Andmentioning

confidence: 97%

Pregnancy, progesterone and progestins in relation to breast cancer risk

Campagnoli

Abbà

Ambroggio

et al. 2005

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Hormonal Factors That Affect Breast Tissue Modifications Andmentioning

confidence: 97%

Pregnancy, progesterone and progestins in relation to breast cancer risk

Campagnoli

Abbà

Ambroggio

et al. 2005

The Journal of Steroid Biochemistry and Molecular Biology

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“…Excessive estrogenic activities have been associated with the development of cancer in estrogen-responsive tissues (e.g., breast and uterus). Decreased levels of E 3 have been linked to complications of eclampsia and an increased probability of Down’s syndrome in offspring [96,97]. Therefore, understanding the mechanisms that influence or disrupt all estrogenic actions is crucial for preventing negative outcomes.…”

Section: Types Of Estrogens and Estrogen Mimeticsmentioning

confidence: 99%

Non-Genomic Effects of Xenoestrogen Mixtures

Viñas

Jeng

Watson

2012

IJERPH

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Xenoestrogens (XEs) are chemicals derived from a variety of natural and anthropogenic sources that can interfere with endogenous estrogens by either mimicking or blocking their responses via non-genomic and/or genomic signaling mechanisms. Disruption of estrogens’ actions through the less-studied non-genomic pathway can alter such functional end points as cell proliferation, peptide hormone release, catecholamine transport, and apoptosis, among others. Studies of potentially adverse effects due to mixtures and to low doses of endocrine-disrupting chemicals have recently become more feasible, though few so far have included actions via the non-genomic pathway. Physiologic estrogens and XEs evoke non-monotonic dose responses, with different compounds having different patterns of actions dependent on concentration and time, making mixture assessments all the more challenging. In order to understand the spectrum of toxicities and their mechanisms, future work should focus on carefully studying individual and mixture components across a range of concentrations and cellular pathways in a variety of tissue types.

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“…Other endogenous estrogenic compounds can be more prevalent during other life phases where they can have significant effects on tissue development, function, and disease states. Estrone (E 1 ) is a significant estrogenic hormone contributor in both reproductive (~0.5-1 nM) and postmenopausal (150-200 pM) women and in men; estriol (E 3 ) levels are much higher in pregnant women (~10-100 nM) than in nonpregnant women (<7 nM) [1], and changes in free E 3 levels in pregnancy have been associated with complications of eclampsia [2] and the incidence of Down’s syndrome in offspring [3]. All three of these physiologic estrogens are also produced by aromatases in a number of nonreproductive tissues where their effects may extend beyond reproductive functions [4,5].…”

Section: Introductionmentioning

confidence: 99%

Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I

Watson

Jeng

et al. 2012

Steroids

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Multiple physiologic estrogens (estradiol, estriol, and estrone), as well as xenoestrogenic compounds (including alkylphenols and bisphenol A), can act via nongenomic signaling initiated by liganding of the plasma membrane estrogen receptor-α (mERα). We examined heterotrimeric G protein involvement leading to extracellular-regulated kinase (ERK) activation in GH3/B6/F10 rat anterior pituitary tumor cells that express abundant mERα, and smaller amounts of mERβ and GPR30. A combination of microarrays, immunoblots, and quantitative immunoassays demonstrated the expression of members of all α, β, and γ G protein classes in these cells. Use of selective inhibitors showed that the Gαi subtype was the primary initiator of downstream ERK signaling. Using antibodies against the GTP-bound form of Gα protein subtypes i and s, we showed that xenoestrogens (bisphenol A, nonylphenol) activated Gαi at 15-30 sec; all alkylphenols examined subsequently suppressed activation by 5 min. GTP-activation of Gαi for all estrogens was enhanced by irreversible cumulative binding to GTPγS. In contrast, Gαs was neither activated nor deactivated by these treatments with estrogens. ERα and Gαi co-localized outside nuclei and could be immuno-captured together. Interactions of ERα with Gαi and caveolin I were demonstrated by epitope proximity ligation assays. An ERα/β antagonist (ICI182780) and a selective disruptor of caveolar structures (nystatin) blocked estrogen-induced ERK activation. Conclusions Xenoestrogens, like physiologic estrogens, can evoke downstream kinase signaling involving selective interactions of ERα with Gαi and caveolin I, but with some different characteristics, which could explain their disruptive actions.

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Midtrimester triple test levels in women with severe preeclampsia and HELLP syndrome

Abstract: Unexplained high levels of midtrimester MShCG and low levels of MSuE3 may be associated with the development of HELLP syndrome in women with severe preeclampsia.

Cited by 15 publications

References 20 publications

Pregnancy, progesterone and progestins in relation to breast cancer risk

Pregnancy, progesterone and progestins in relation to breast cancer risk

Non-Genomic Effects of Xenoestrogen Mixtures

Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I

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