Midkine is overexpressed in acute pancreatitis and promotes the pancreatic recovery in L‐arginine‐induced acute pancreatitis in mice

Cheng, Li; Qiao, Zhenguo; Xu, Chunfang; Shen, Jiaqing

doi:10.1111/jgh.13681

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…To further confirm the protective effect of ISL on AP, we used a SAP mouse model induced by L-arginine. SAP was induced by injecting 4 g/kg/h L-arginine twice, and mice were treated with 100 mg/kg ISL intraperitoneally at 24 h, 36 h, 48 h, and 60 h after the first injection of L-arginine [ 29 ]. Unsurprisingly, the severity of pancreatic tissue injury, including acinar cell necrosis, edema, and inflammatory cell infiltration, was alleviated after ISL treatment (Figures 6(d) and 6(e) ).…”

Section: Resultsmentioning

confidence: 99%

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

Liu

Zhu

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

133

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Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However, the specific effects of ISL on AP have not been determined. In this study, we aimed to investigate the protective effect of ISL on AP using two mouse models. In the caerulein-induced mild acute pancreatitis (MAP) model, dynamic changes in oxidative stress injury of the pancreatic tissue were observed after AP onset. We found that ISL administration reduced serum amylase and lipase levels and alleviated the histopathological manifestations of pancreatic tissue in a dose-dependent manner. Meanwhile, ISL decreased the oxidative stress injury and increased the protein expression of the Nrf2/HO-1 pathway. In addition, after administering a Nrf2 inhibitor (ML385) or HO-1 inhibitor (zinc protoporphyrin) to block the Nrf2/HO-1 pathway, we failed to observe the protective effects of ISL on AP in mice. Furthermore, we found that ISL mitigated the severity of pancreatic tissue injury and pancreatitis-associated lung injury in a severe acute pancreatitis model induced by L-arginine. Taken together, our data for the first time confirmed the protective effects of ISL on AP in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway.

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Section: Resultsmentioning

confidence: 99%

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

Liu

Zhu

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

133

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MOF-based ratiometric fluorescent nanoprobe for quantitative detection of hydrogen sulfide in acute pancreatitis

Yang,

Liang,

Zhao

et al. 2024

Microchemical Journal

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Paeonol protects against acute pancreatitis by Nrf2 and NF-κB pathways in mice

Zhang

Yin²,

Wang

et al. 2022

Journal of Pharmacy and Pharmacology

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Objectives Paeonol (PAE) is an active ingredient with anti-inflammatory and antioxidant properties. This study was designed to investigate the effect of PAE on acute pancreatitis (AP). Methods AP was induced by the intraperitoneal injection of 20% l-arginine (4 g/kg) for 6 h. Mice were pretreated with PAE (25, 50 or 100 mg/kg) intragastrically for 5 days. The histological damage and alterations of biochemical indicators, inflammatory cytokines and oxidative stress factors in AP mice were detected. The Nrf2 and NF-κB pathways were examined to illustrate the potential mechanism. Key findings In AP model, we found that PAE attenuated histological injury of pancreatic tissues, reduced the serum levels of α-amylase and increased Ca2+ contents in a dose-dependent manner. The white blood cell content, and IL-1β, IL-6 and TNF-α levels in the serum of AP mice were reduced by PAE. Furthermore, PAE caused a reduction of MPO and MDA levels, accompanied by an increase in SOD activity in the pancreas of AP mice. We also demonstrated that the alterations of Nrf2 and NF-κB pathways in AP mice were reversed by PAE. Conclusions PAE attenuates inflammation and oxidative stress in the development of AP by the regulation of Nrf2 and NF-κB pathways.

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Midkine is overexpressed in acute pancreatitis and promotes the pancreatic recovery in L‐arginine‐induced acute pancreatitis in mice

Cited by 4 publications

References 32 publications

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

MOF-based ratiometric fluorescent nanoprobe for quantitative detection of hydrogen sulfide in acute pancreatitis

Paeonol protects against acute pancreatitis by Nrf2 and NF-κB pathways in mice

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