Middle Term Impact of Sleeve Gastrectomy on Major Cardiovascular Risk Factors in a Group of Romanian Obese Patients

Timofte, Daniel; Hristov, Ioana; Zugun‐Eloae, Florin; Ungureanu, M C; Găleşanu, Corina; Mocanu, Veronica

doi:10.4183/aeb.2017.454

Cited by 2 publications

(2 citation statements)

References 26 publications

(23 reference statements)

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“…Similar to other studies (12,20,(24)(25)(26), we observed an early improvement of glucose homeostasis, followed by a stabilization of glycemic parameters.…”

Section: Discussionsupporting

confidence: 92%

Long-Term Improvement of Glucose Homeostasis and Body Composition in Patients Undergoing Laparoscopic Sleeve Gastrectomy

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et al. 2018

Acta Endo (Buc)

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Context. Laparoscopic sleeve gastrectomy (SG) has gained popularity as a metabolic procedure, but its longterm effectiveness for Romanian patients remains unclear. Objectives. To assess the long-term efficacy of SG for Romanian patients and to evaluate the differences between 5 years and 1 year follow-up. Design. A longitudinal, prospective analysis of collected data from 68 patients undergoing SG between 2009 and 2014 was performed. Long-term outcomes at 5 years were analyzed in terms of total weight loss (%TWL), excess weight loss (%EWL), body composition and glucose homeostasis. Subjects and Methods. All patients meeting the standard criteria for SG before inclusion were prospectively enrolled in the study. Of the 68 patients, eight were lost to follow-up, therefore, 60 patients (41.7±12.5 years, baseline body mass index [BMI] 44.6±9.9Kg/m 2) were analyzed. Results. The BMI decreased at 12 months with 30.7% from the preoperative BMI (p<0.001) and subsequently stabilized at 5 years. TWL and EWL were 30.6% and 83.1%, respectively at 1 year, with a slightly increase at 5 years. Therapeutic success rate (%EWL≥50) and diabetes remission rate (Buchwald criteria) were 93.3% and respectively 63.6% at 5 years. Insulin sensitivity index and metabolic clearance rate of glucose increased with 92.5% and 60.1% respectively, in the third month from baseline (p<0.001), while estimated second phase of insulin secretion decreased with 7.9% in the first month postoperatively (p=0.04), remaining stable afterwards. Conclusions. SG was effective in terms of %EWL, body composition and glucose homeostasis improvement for Romanian patients, the outcomes stabilizing after 1 year follow-up.

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“…Similar to other studies (12,20,(24)(25)(26), we observed an early improvement of glucose homeostasis, followed by a stabilization of glycemic parameters.…”

Section: Discussionsupporting

confidence: 92%

Long-Term Improvement of Glucose Homeostasis and Body Composition in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Zetu

Popa

Popa³

et al. 2018

Acta Endo (Buc)

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“…Taken into consideration the chronic history of obesity, longer observation most probably might reveal more beneficial clinical effects. Bariatric surgery has been shown significant beneficial effects on metabolic syndrome features (17,18), and on major cardiovascular risk factors (19). Likewise, patients in our study demonstrated favorable changes in blood glucose, insulin, HbA1c, CRP, leptin, adiponectin levels, heart rate, sABP 4 years after the LAGB.…”

Section: Discussionsupporting

confidence: 71%

Effects of Body Weight Reduction on Arterial Stiffness and Endothelial Function after Bariatric Surgery in Morbidly Obese Patients: A 4-Year Clinical Study

et al. 2018

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Objective. To determine the long-term effect of weight loss on arterial stiffness, metabolic parameters in morbidly obese patients who underwent laparoscopic adjustable gastric banding (LAGB). Subjects. Forty-eight morbidly obese Caucasian subjects underwent LAGB from January 2009 to January 2010 and completed 4 years follow-up. Measurements. Patients were evaluated for body mass index (BMI), waist circumference, arterial blood pressure (BP), metabolic factors: leptin, adiponectin, glucose, glycated haemoglobin (HbA1c), insulin. Endothelial functionevaluated as reactive hyperemic index (RHI). Arterial stiffness-determined by cardio-ankle vascular index (CAVI). Results. Average BMI decreased from 46.48±7.06 kg/m 2 to 39.78±7.36 kg/m 2 (1year, p<0.001) and 37.29±7.49 kg/m 2 (4years, p=0.012). The systolic BP and heart rate reduction were observed after the 4 years. Changes in cardiovascular parameters were accompanied by waist circumference reduction and improvement of glucose metabolism,reduction of insulin, HbA1c, leptin, C-reactive protein values. However, there were statistically significant increases in CAVI 6.58±1.77m/s vs. 7.03±2.00 m/s (p=0.014) at 1 year, but not significant 7.12±2.19 (p=0.153) after 4 years. Endothelial changes were observed only in diabetic patients one year after LAGB 2.18±0.57 vs. 1.86±0.34 (p=0.021) vs. 2.05±0.42 (p=0.086). Conclusion. Weight reduction induced by LAGB was associated with changes in body weight and metabolic parameters, but it was no improvement on endothelial function and arterial stiffness.

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Middle Term Impact of Sleeve Gastrectomy on Major Cardiovascular Risk Factors in a Group of Romanian Obese Patients

Cited by 2 publications

References 26 publications

Long-Term Improvement of Glucose Homeostasis and Body Composition in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Long-Term Improvement of Glucose Homeostasis and Body Composition in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Effects of Body Weight Reduction on Arterial Stiffness and Endothelial Function after Bariatric Surgery in Morbidly Obese Patients: A 4-Year Clinical Study

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