Effects of Body Weight Reduction on Arterial Stiffness and Endothelial Function after Bariatric Surgery in Morbidly Obese Patients: A 4-Year Clinical Study

Galkinė, Aistė; Dženkevičiūtė, V.; Šapoka, Virginijus; Urbanavičius, Vaidotas; Petrulionienė, Ž.; Brimas, Gintautas; Laucevičius, Aleksandras

doi:10.4183/aeb.2018.491

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Neither of the measures changed significantly, in apparent disagreement with our finding. Similarly, Galkine et al [29] studied changes in CAVI after bariatric surgery in patients with at least one comorbidity, reporting an increase in CAVI at 1 year and no difference from baseline at a 4-year follow-up. Explanations for this disparity are that CAVI and baPWV are global indices of arterial stiffness, including long muscular arterial pathways, while central (aortic) PWV and our lnDU-loop method provide central and here local measures of PWV.…”

Section: Discussionmentioning

confidence: 99%

Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity

et al. 2020

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Purpose Obesity clearly increases cardiovascular risk, often inducing high blood pressure (BP), impaired left ventricular (LV) function, and increased arterial stiffness. Intensive weight loss and bariatric surgery induce improvement in hypertension and diabetes for morbid obesity. Carotid artery haemodynamics is a powerful prognostic indicator for stroke and cognitive decline independent of BP. The aim of this study was to evaluate the impact of a 3-stage bariatric strategy of diet, bariatric surgery, and consequent weight loss on carotid haemodynamics and cardiac diastolic function. Material and Methods This prospective study included 26 patients (45 ± 10 years, 4 men) with severe obesity undergoing bariatric surgery without comorbidities (hypertension, diabetes, etc.). Anthropometry, BP, Doppler echocardiography, and common carotid haemodynamics by ultrasound were measured at three times: (1) baseline, (2) after 1-month diet (post-diet), and (3) 8 months after surgery (post-surgery). The lnDU-loop method was used to estimate local carotid pulse wave velocity (ncPWV). Results Baseline BMI was 47.9 ± 7.1 kg/m2 and reduced by 5% and 30% post-diet and post-surgery, respectively. BP decreased only post-diet, without pulse pressure change. However, ncPWV, 6.27 ± 1.35 m/s at baseline, was significantly reduced by 10% and 23% post-diet and post-surgery, respectively, also adjusted for BP changes. The E/A ratio rose from 0.95 ± 0.20 to 1.27 ± 0.31 (p < 0.005), without change in LV geometry or mass, while heart rate and cardiac output fell substantially. Conclusion Weight loss following diet and bariatric surgery is associated with reduced carotid arterial stiffness and improved LV diastolic function. Diet and bariatric surgery are effective treatments for morbid obesity with its concomitant adverse cardiovascular effects.

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Section: Discussionmentioning

confidence: 99%

Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity

et al. 2020

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“…Besides genetic predisposal, environmental factors, e.g. diet and obesity, were described to influence the risk of various disorders, such as cardiovascular disease (1), but also CRC (2).…”

Section: Introductionmentioning

confidence: 99%

Variations of Adipokine Profile in Patients Diagnosed with Rectal Carcinoma

et al. 2019

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Background. Adipokine secretion is influenced by various disease conditions.Purpose. We wanted to check the impact of rectal carcinoma (RC) on adipokine profile.Patients and methods. We evaluated serum leptin and adiponectin levels in 24 RC patients (12 males and 12 females) as well as in the same number of age, sex and weight-matched healthy controls.Results. Adipokines were oppositely correlated with body weight (BW) in controls and RC patients. Women had higher adipokine levels than men. Healthy controls had higher leptin (37.6.±7.8 vs. 7.9±2.6 ng/mL in women and 11.9±4.6 vs. 1.4±0.34 ng/mL in men, p=0.0016 and 0.043) and lower adiponectin levels (9.3±1.1 vs. 14.9±1.1 µg/mL in women and 7.9±0.9 vs. 11.1±0.9 µg/mL in men, p=0.012 and 0.017) than RC patients.Conclusion. Adipokine profiles of patients with RC differ from the healthy population, possibly reflecting an adaptation to the disease rather than a triggering factor. These differences may find clinical applications for the prognosis of disease evolution.

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