Middle Ear Papilloma

Torres, Sandro; Castro, Thomas Wagner; Bento, Ricardo Ferreira; Lessa, Hélio A.

doi:10.1016/s1808-8694(15)30092-6

Cited by 7 publications

(4 citation statements)

References 5 publications

(7 reference statements)

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“…Clinical presentation mostly resembles chronic otitis media with polyp formation in the posterior tympanic membrane segments, but a glomus tympanicum should also be considered, especially if there is brisk bleeding present upon manipulation 6 , as well as Eustachian tube dysfunction. 7,8 The etiology is probably multifactorialno cases so far have been unequivocally linked with HPV infection, including ours, yet its contribution cannot be ruled out completely. 6 Histological features are similar to sinonasal localized Schneiderian-type papillomas.…”

Section: Discussionmentioning

confidence: 80%

“…3 Recurrence was reported at 100% in all previously reported cases treated only with tympanoplasty and simple excision compared to 39% following radical surgery (mastoidectomy or temporal bone resection). 7,8 These results can be compared with recurrence rates of ISP when treated with a similar extent of surgery. 1 The treatment of choice is surgery-radical tympanomastoidectomy, with other approaches proving inefficient in disease control.…”

Section: Discussionmentioning

confidence: 99%

“…6 Sinonasal papillomas are divided into three histological types: exophytic (ESP), oncocytic (OSP), and inverted (ISP) 3 , which is the most common (60%). [6][7][8][9][10] While it is considered benign, it is locally aggressive and tends to invade adjacent structures. Disease incidence cannot be accurately calculated due to scarce reports in literature.…”

Section: Introductionmentioning

confidence: 99%

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Multifocal metachronous occurence of different hystologic sinonasal-type papilloma

Ajduk,

Peček,

Pierobon

et al. 2024

Med. Jadert. (Online)

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Introduction: Sinonasal-type papilloma is a very rare tumor, most commonly connected with the sinonasal space, and very rarely with the middle ear. Primary tumors of the temporal bone are extremely rare and only 28 cases have been described in literature, with additional 29 cases of tumor spreading from the sinonasal tract to the temporal bone. Case presentation: We discuss the case of a 49-year-old woman who had a primary right-sided exophytic form of the sinonasal papilloma of the middle ear, which led to right-sided hearing loss, aural fullness, and otorrhea. During postoperative CT and MRI follow-up one year after surgery, a sinonasal oncocytic-type papilloma was discovered in the sphenoid sinus. To our knowledge, this is the first described case of histologically two different primary sinonasal-types of papilloma in a patient. Common presenting symptoms associated with sinonasal papilloma of the middle ear can be easily misdiagnosed with chronic otitis media or Eustachian tube dysfunction. Although primarily benign, sinonasal papillomas are locally aggressive and pose a risk of recurrence and malignant transformation. Therefore, surgery remains the treatment of choice with necessary long-term follow-up, to detect relapse or even a completely new tumor in that area.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multifocal metachronous occurence of different hystologic sinonasal-type papilloma

Ajduk,

Peček,

Pierobon

et al. 2024

Med. Jadert. (Online)

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“…Primary middle ear squamous papilloma is an exceedingly rare temporal bone neoplasm and an Ovid Medline search using the search terms ‘squamous papilloma’ and ‘middle ear/temporal bone’ returned only two cases in the English literature (2,8). The data in the previous literature consisted only of case reports and the clinical features and pathogenesis of the tumor are vague due to the low frequency of the disease.…”

Section: Discussionmentioning

confidence: 99%

Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization

et al. 2013

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Squamous papilloma involving the middle ear as a primary lesion is an extremely rare occurrence. The aims of the present study were to investigate the presence of human papilloma virus (HPV) and Epstein-Barr virus (EBV) infections in primary middle ear squamous papilloma and to describe the clinical and pathological features of the disease along with therapeutic strategies. A retrospective review was conducted of four patients with clinical and pathological diagnoses of middle ear squamous papilloma. In situ hybridization (ISH) for a wide range of HPV DNA subtypes and EBV-encoded RNA was performed in the tissue samples obtained from these patients. Only two cases of primary squamous papilloma in the middle ear have been previously reported in the English literature. These papillomas developed in males of ~60-years of age and otorrhea was the most frequent complaint. Premalignant changes were observed in two of the present cases and ISH of HPV and EBV was negative in all four cases. The results of the present study indicated that chronic inflammatory stimulation, not HPV and EBV infection, is involved in the occurrence of middle ear squamous papilloma and its malignant transformation. Radical surgery and long-term postoperative follow-up are recommended due to its malignant and recurrent potential. Further genetic investigations with additional new cases are required to clarify the pathogenesis of squamous papilloma involving the middle ear.

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