Middle Ear Mucosa

Sadé, Jacob

doi:10.1001/archotol.1966.00760030139005

Cited by 197 publications

(44 citation statements)

References 16 publications

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“…In his view, such a ciliated cell system is more devel oped near the tympanic orifice of the tube and less in the hypotympanum, epitympanum and promontory. In 1966 Sade [ 18] reported that the ciliated respiratory epithelium covers the antero-inferior half to two thirds of the tym panic cavity including the hypotympanun, the anterior part of the promontory and the roof of the epitympanum. In 1976, Tos and Bak-Pedersen [3,4] observed that the number of goblet cells gradually decreased from the ante rior and posterior hypotympanum, the promontory and the anterior epitympanum to the oval window and the posterior promontory.…”

Section: Discussionmentioning

confidence: 99%

Morphological Distribution of Middle-Ear Epithelium in the Wistar Rat: A Functional Hypothesis

Scarano

Paludetti²,

Frusoni³

et al. 1997

ORL

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The authors studied the overall microscopical anatomy of the middle ear and of the eustachian tube in 20 tympanic bullae of 10 Wistar rats. Large hexagonal epithelial flat cells covered the roof of the bulla, the two upper thirds of both lateral walls, the upper half of the eustachian tube, and the upper third of the tympanic orifice; ciliated and secretory cells lined the inferior thirds of both walls of the bulla while a ciliated epithelium with strong cilia, all directed towards the tubal orifice, located on the floor of the tympanic cavity together with groups of non-ciliated cells was detectable near the tubal and antral areas and on the floor of the eustachian tube. Non-ciliated cells covered by microvilli were found near the pharyngeal orifice. These observations seem to demonstrate the following: (1) the ciliated elements present a well-defined topographic distribution; (2) a preferential pathway for mucociliary clearance made up of strong ciliated cells located on the floor of the bulla is clearly detectable, and (3) the roof of the bulla seems to be mainly involved in the ventilatory function.

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Section: Discussionmentioning

confidence: 99%

Morphological Distribution of Middle-Ear Epithelium in the Wistar Rat: A Functional Hypothesis

Scarano

Paludetti²,

Frusoni³

et al. 1997

ORL

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“…A single-or a two-to three-layered cuboid epithelium and a pseudostratified columnar epithelium, often ciliated, developed resembling the normal middle ear mucosa [Sade, 1966;Lim and Hussl, 1969;Hentzer, 1970;Shimada and Lim, 1972;Lim et al, 1973). In some cases there was a simple flat epithelium with scanty secretory activity in the form of coarse PAS-positive granules.…”

Section: Discussionmentioning

confidence: 99%

Regenerated Middle Ear Mucosa after Tympanoplasty

Gamoletti¹,

Zini²,

Sanna³

et al. 1982

ORL

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The surgeon’s attitude towards the diseased middle ear mucosa during intact canal wall tympanoplasty has remained a controversial problem. Our approach consists of the complete removal of the irreversibly diseased mucosal lining. A planned staged operation has been carried out in most cases of tympanoplasty with the use of Silastic sheeting. At the time of the second operation, the middle ear and mastoid process appear to be lined by the regenerated mucosa and pneumatized. 54 mucosal biopsies taken during the second stage of the operation showed a normal flat, cuboidal and pseudostratified ciliated epithelium with functional features (secretory granules, microvilli and cilia). It is concluded that the diseased middle ear mucosa can be removed whenever necessary during staged closed-tympanoplasty operations because under the Silastic sheeting the mucosa will be regenerated within 12 months.

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“…In a study of temporal bones from 80 patients who had not had any otological disease at the time of death, Sade [18] found mucous glands in the majority and claimed that these glands are normal components of the middle ear mucosa. To solve this important question of normality versus abnormality, we have performed extensive studies on whole-mounted and sectioned tissue, investigating the entire mucosa of temporal bones from fetuses and prematures [3,4], newborn infants [19], children [20] and adults [21].…”

Section: Are Glands a Normal Component Of The Middle Ear Mucosa?mentioning

confidence: 99%

Mucous Glands in the Middle Ear – What Is Known and What Is Not

Tos

Cayé‐Thomasen²

2002

ORL

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A review of acquired and lacking knowledge on mucous glands in the human middle ear is presented. Investigations on whole-mount and section preparations from fetuses, prematures and infants, normal and slightly abnormal children and adults are reviewed in detail. It is concluded that mucous glands are not a normal, but a pathological component of the middle ear mucosa. Gland formation and degeneration are described. Theories on pathogenesis are discussed and new ideas for further research are indicated.

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Middle Ear Mucosa

Cited by 197 publications

References 16 publications

Morphological Distribution of Middle-Ear Epithelium in the Wistar Rat: A Functional Hypothesis

Morphological Distribution of Middle-Ear Epithelium in the Wistar Rat: A Functional Hypothesis

Regenerated Middle Ear Mucosa after Tympanoplasty

Mucous Glands in the Middle Ear – What Is Known and What Is Not

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