Mucous Glands in the Middle Ear – What Is Known and What Is Not

Tos, Mirko; Cayé‐Thomasen, Per

doi:10.1159/000057786

Cited by 19 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From this viewpoint, one would argue that chronic OM triggers gland-like mucous cell differentiation in response to middle ear infections [29]. Indeed, in the surgical samples with chronic OM or mastoiditis, it has been observed that gland-like structures with abundant mucous cells are pathologically identified in the middle ear and mastoid area [30].…”

Section: Mucin Dysregulation In Ommentioning

confidence: 99%

“…One of the manifestations of mucous cell metaplasia/hyperplasia is accumulation of mucoid effusion in the middle ear cavity [4, 29, 34, 53–57]. It is natural, on one hand, that mucus accumulated in the middle ear cavity if the Eustachian tube is not functional.…”

Section: Mucoid Effusion In Ommentioning

confidence: 99%

“…This may explain why S. pneumoniae tends to cause mucous cell metaplasia/hyperplasia. However, both Gram-positive and -negative bacteria are potent inducers of mucous cell metaplasia/hyperplasia.Tos and Caye-Thomasenobserved an increased goblet cell density in acute OM, variable by causative pathogen [22]. …”

Section: Introductionmentioning

confidence: 99%

“…It is difficult to fully restore the mucous cell population or density back to the baseline level once mucous cell metaplasia/hyperplasia occurs in the middle ear mucosa. An episode of middle ear infection always adds some goblet cells to the mucosa even the infection even is long gone [22, 23]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mucin Production and Mucous Cell Metaplasia in Otitis Media

Lin

Cayé‐Thomasen

Tono

et al. 2012

International Journal of Otolaryngology

Self Cite

View full text Add to dashboard Cite

Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed.

show abstract

Section: Mucin Dysregulation In Ommentioning

confidence: 99%

Section: Mucoid Effusion In Ommentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mucin Production and Mucous Cell Metaplasia in Otitis Media

Lin

Cayé‐Thomasen

Tono

et al. 2012

International Journal of Otolaryngology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The normal presence of mucous glands may distinguish ET mucosa from middle-ear mucosa. In fact, Tos and Caye-Thomasen [9] stated that mucous glands are never a normal component of the middleear mucosa, but the expression of an inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Primary tumors and tumor-like lesions of the eustachian tube: a systematic review of an emerging entity

Muzzi

Cama

Boscolo‐Rizzo

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Eustachian tube (ET) primary tumors and tumor-like lesions are rare diseases presenting with common ear, nose and throat symptoms. Pathology can range from developmental anomalies to high malignant neoplasms. Hence this review aimed at suggesting a classification and outline relevant aspects of ET primary tumors and tumor-like lesions, describing clinical findings, diagnostic management and therapeutic approaches. MEDLINE, CINAHL, OVIDSP, HIGHWIRE, and GOOGLE databases were searched from inception to July 2011 for relevant studies. Further papers were identified by examining the reference lists of all included. Sixty-five papers met the inclusion criteria, enclosing 78 cases. Case reports are increasing in the past few years. Benign lesions and tumor-like lesions of ET have been reported. Moreover, melanomas, carcinomas, and sarcomas can affect the ET as a primary site.

show abstract