Midazolam for the Intravenous Induction of Anaesthesia in Children

Abstract

Midazolam was compared with thiopentone as an intravenous anaesthetic induction agent in children between four and twelve years of age undergoing elective minor surgical procedures. Successful induction of anaesthesia was achieved in both groups of patients. With midazolam induction time was longer than with thiopentone, but the difference was not statistically significant. The incidence of apnoea was greater with thiopentone, but not significantly so. lt is concluded that midazolam is effective and safe, and could prove a reasonable alternative to thiopentone as an intravenous induction agent in children undergoing elective minor operations.

A Comparison of Three Induction Agents in Paediatric Anaesthesia—Cardiovascular Effects and Recovery

“…The wide variation of ASA class, clinical condition, anaesthetic technique and interpatient response makes comparative interpretation of these results difficult. Early reports demonstrated no haemodynamic difference between midazolam and thiopentone, but data were collected at five-minute intervals 27 • A comparative study of the haemodynamic sequelae associated with midazolam and propofol induction have not been reported but there are a number of controlled studies comparing thiopentone and propofol in children 4 ,5,28. These studies showed the reduction of blood pressure to be less in the Anaesthesia and Intensive Care, Vol. 22, No.…”

Midazolam as a Sedative in Esophageal Manometry

“…Intravenous midazolam is safe for children (8,10). Hemod ynamic responses to intravenous midazolam include tachycardia and hypotension similar to those of diazepam (11 ,12), and less than (11 ,13) or same as those of thiopental (10). At a dose of 0.25 mg/kg, midazolam did not cause significant decrease in systolic and diastolic blood pressure « 3 mm Hg).…”

“…The fast induction of sedation in our study was compatible with the experience of Cole et al (8). In fact , the onset of action of midazolam is usually more rapid in children than in adults (8,10). Intravenous midazolam is safe for children (8,10).…”

Oral Sedation of Pediatric Patients for Noninvasive Radiological Procedures: Chloral Hydrate Versus Midazolam

“…Midazolam has received widespread acceptance as an anxiolytic agent before anesthesia in pediatric and adult patients (Holloway, Jordaan, & Brock-Utne, 1982;Reves, Fragen, Vinik, & Greenblatt, 1985;Rochette et al, 1984). It is less well known for its sedative and hypnotic effects.…”