“…Refractive index optical sensors based on plasmonic , and photonic micro and nanostructures − have recently attracted increased attention for the realization of ultrasensitive and ultracompact refractometers. Either evanescent field (e.g., surface plasmon resonance, − long period grating fibers ,, ) or resonant (e.g., localized SPR, − ring resonators , ) and interference (e.g., interferometers, − photonic crystals , ) effects between electromagnetic field and matter of interest have been exploited to quantify refractive index variations by increasing the light–matter interaction at the micro and/or nanoscale. An increased light–matter interaction leads, indeed, to an augmented sensitivity ( S ) and, in turn, to a higher resolution ( R ) that ultimately gives the minimum variation of refractive index that can be resolved above the noise floor (σ), also known as detection limit (DL = 3σ/ S ) .…”