Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women

Abstract

ObjectiveTo investigate the relationship between mid-gestational serum uric acid and birth weight in diabetic pregnant women with or without insulin resistance.Methods:In a prospective cohort study, fasting uric acid, blood glucose, and serum insulin were measured in 247 pregnant women between 20-22 weeks of gestational period. Insulin resistance was estimated using the homeostasis model assessment-insulin resistance (HOMA-IR). Stratification analysis and independent t-test was used to assess the association between uric acid and birth weights regarding to insulin resistance.Results:The means of the mid-gestational serum uric acid concentrations were not significantly different in women with and without insulin resistance. But stratification analysis showed that there was a significant difference between uric acid concentration and macrosomic birth in diabetic women without insulin resistance.Conclusions:Higher mid – gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non-insulin resistance women. Insulin resistance could have a negative confounding effect on hyperuriemia and birth weight.

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes

“…However, a systematic review by Thangaratinam et al [ 31 ] reported UA as a rather poor predictor. Amniotic fluid UA levels were shown to be a predictor of infant birth [ 32 ]; furthermore, higher UA levels were also associated with lower birth weight in normotensive women without insulin resistance (determined using a homeostatic model assessment for insulin resistance (HOMA-IR)) [ 33 ]. However, the evidence for the pathogenic relationship between gestational UA levels and child weight, preeclampsia, or hypertensive adverse pregnancy outcomes is scarce so far.…”