Abstract:We report mid-aortic syndrome (MAC) in two preterm infants. Both infants developed malignant hypertension refractory to medical therapy and died early in infancy. Thus far, this account is of the two youngest patients with MAC. Journal of Perinatology (2012) 32, 390-392; doi:10.1038/jp.2011 Keywords: preterm; mid-aortic syndrome; hypertension Introduction Mid-aortic syndrome (MAS) is a rare but important cause of renovascular hypertension in children and young adults. 1 It is characterized by segmental narrowi… Show more
“…She had an improvement in blood pressure, however hypertension persisted. In uncontrolled hypertension, endovascular percutaneous transluminal angioplasty with or without stents or balloon dilation have been performed in children and adolescents, however symptomatic MAS in newborn period is almost fatal 3,[11][12][13][14] . Balloon dilation and stenting are effective for short-segment lesions but do not yield favorable results in patients with long-segment stenosis 15. As the present patient was only 2600 g, we wanted to do medical treatment allowing her to grow until surgery or stent placement.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately she died due to heart failure. To our knowledge there are only 9 newborn cases in the literature [10][11][12][13][14]16,17 . Five of 9 babies died secondary to intraventricular hemorrhage or cardiac failure 10,[12][13][14] .…”
Öz Midaortic syndrome is an uncommon disease characterized by segmental or diffuse narrowing of abdominal or distal descending thorasic aorta. Majority of the cases are idiopathic but some are secondary to fibromuscular dysplasia, giant cell arteritis, Moyamoya disease or genetic diseases such as neurofibromatosis, Williams' syndrome and Alagille syndrome. It is very rare in newborn period. Here we present a 40 days old infant who admitted to hospital for respiratory distress, hypertension, heart failure and was diagnosed as midaortic syndrome. She had medical treatment but unfortunately died due to heart failure when she was two months old age. Midaortik sendrom nadir bir hastalık olup abdominal veya distal inen aortanın segmental veya difüz darlığı ile karakterizedir. Olguların çoğu idiyopatik olmakla birlikte bir kısmı da fibromüsküler displazi, dev hücreli aterit, Moyamoya hastalığı veya nörofibramatozis, Williams' sendromu ve Alagille sendromu gibi genetik hastalıklara ikincildir. Burada 40 günlük iken hastaneye solunum sıkıntısı, kalp yetmezliği tablosunda başvuran ve midaortik sendrom tanısı alan bir olgu sunulmuştur. Olguda medikal tedavi tercih edilmiş ancak bebek iki aylık iken eksitus olmuştur.
“…She had an improvement in blood pressure, however hypertension persisted. In uncontrolled hypertension, endovascular percutaneous transluminal angioplasty with or without stents or balloon dilation have been performed in children and adolescents, however symptomatic MAS in newborn period is almost fatal 3,[11][12][13][14] . Balloon dilation and stenting are effective for short-segment lesions but do not yield favorable results in patients with long-segment stenosis 15. As the present patient was only 2600 g, we wanted to do medical treatment allowing her to grow until surgery or stent placement.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately she died due to heart failure. To our knowledge there are only 9 newborn cases in the literature [10][11][12][13][14]16,17 . Five of 9 babies died secondary to intraventricular hemorrhage or cardiac failure 10,[12][13][14] .…”
Öz Midaortic syndrome is an uncommon disease characterized by segmental or diffuse narrowing of abdominal or distal descending thorasic aorta. Majority of the cases are idiopathic but some are secondary to fibromuscular dysplasia, giant cell arteritis, Moyamoya disease or genetic diseases such as neurofibromatosis, Williams' syndrome and Alagille syndrome. It is very rare in newborn period. Here we present a 40 days old infant who admitted to hospital for respiratory distress, hypertension, heart failure and was diagnosed as midaortic syndrome. She had medical treatment but unfortunately died due to heart failure when she was two months old age. Midaortik sendrom nadir bir hastalık olup abdominal veya distal inen aortanın segmental veya difüz darlığı ile karakterizedir. Olguların çoğu idiyopatik olmakla birlikte bir kısmı da fibromüsküler displazi, dev hücreli aterit, Moyamoya hastalığı veya nörofibramatozis, Williams' sendromu ve Alagille sendromu gibi genetik hastalıklara ikincildir. Burada 40 günlük iken hastaneye solunum sıkıntısı, kalp yetmezliği tablosunda başvuran ve midaortik sendrom tanısı alan bir olgu sunulmuştur. Olguda medikal tedavi tercih edilmiş ancak bebek iki aylık iken eksitus olmuştur.
“…Premature mortality remains high in patients who present in the neonatal period with hypertension refractory to medical therapy, as their small size makes endovascular procedures challenging and prohibits surgical management [21,24,38,39]. In older children, however, morbidity and mortality rates are reported to be improving.…”
Middle aortic syndrome is a rare form of renovascular disease that may present with severe hypertension during childhood. Narrowing of the abdominal aorta is often associated with narrowing of the renal and/or other visceral arteries and may be secondary to specific genetic syndromes. Following the optimization of blood pressure control, significant aortic narrowing often requires invasive management, including endovascular and surgical intervention. In younger children, endovascular therapy may be attempted in the first instance to acutely reduce the pressure gradient across the narrowing; however, a sustained benefit is rare. Once the child has grown to accommodate a graft of an adequate size, surgical therapy is indicated for patients in whom medical and/or endovascular management has not resulted in adequate blood pressure control. It is critical that individuals with middle aortic syndrome be managed by an experienced multidisciplinary team that includes medical, endovascular, and surgical expertise that can provide long-term care to monitor for recurrent hypertension and evidence of end-organ damage.
Middle aortic syndrome (MAS) is a rare vascular disease representing an important cause of severe hypertension in children. MAS is characterized by segmental or diffuse narrowing of the abdominal and/or distal descending aorta with involvement of the renal and visceral branches. Most cases of MAS are idiopathic, but MAS may occur in genetic and acquired disorders. The most common genetic causes of MAS are neurofibromatosis type I, Williams syndrome, Alagille syndrome, tuberous sclerosis and mucopolysaccharidosis. This review article discusses the pathophysiological aspects, distinctive associated features, and management of genetic forms of MAS in children.
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