Micturitional headache in a young girl

Yang, Fu‐Chi; Hsu, Yu-Chuan; Chen, Chun-Wen; Wu, Seng-Tang; Lin, Chang-Min; Hsu, Chang-Hung

doi:10.1007/s00431-009-1067-0

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Bladder paraganglioma was first reported by Zimmerman and colleagues in 1953 [5] in an adult patient. The BP cases reported in childhood populations are scant [2,[6][7][8][9][10][11][12][13][14]. To the best of our knowledge, 11 (including the present case) have been reported in the English literature; however, none of the previous published BPs in children has been investigated for the presence of SDHB mutation by immunohistochemistry.…”

Section: Discussionmentioning

confidence: 97%

Urinary Bladder Paraganglioma in Childhood: A Case Report and Review of the Literature

et al. 2011

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Bladder paraganglioma (BP) is a rare entity and is exceedingly uncommon in childhood. Pheochromocytomas/paragangliomas are components of several hereditary cancer syndromes, and up to 30% may be associated with germ-line mutations of genes, including VHL, RET, and SDH. We present a 16-year-old female who was admitted with macroscopic hematuria and anemia. A cystoscopy demonstrated a polypoid and hemorrhagic mass arising from the floor of the bladder. She underwent a transurethral resection of clinically suspected urothelial papilloma. A histologic examination of the tumor showed large polygonal cells with eosinophilic cytoplasm, arranged in a zellballen pattern, surrounded by a fibrous network. Immunohistochemical studies showed a strong expression of neuroendocrine markers and lack of reactivity for epithelial markers. The diagnosis of BP was established; eight months later, a recurrence was observed and the patient underwent a partial cystectomy. Our case represents the 1st BP in childhood reported in the literature with absent SDHB staining by immunohistochemistry. We discuss the clinical and pathologic findings and present a review of BP in childhood.

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Section: Discussionmentioning

confidence: 97%

Urinary Bladder Paraganglioma in Childhood: A Case Report and Review of the Literature

et al. 2011

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Paraganglioma (pheochromocytoma) of the urinary bladder: A systematic review with a diagnostic, management and treatment algorithm

Hooshyari

Tyson

Rice

2022

Journal of Clinical Urology

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Introduction: Paraganglioma of the urinary bladder is a rare but well-documented tumour. Herein, we provide the largest, comprehensive systematic review of the literature and aim to increase familiarity with this rare but significant neoplasm. Methods: A systematic review of the literature was conducted on the NCBI PubMed database. The search criteria were not limited to any specific years or languages. There were 418 articles between January 1953 and August 2020, of which 255 case reports were selected. Results: Paragangliomas of the urinary bladder most commonly occurred in Caucasians in the fifth decade of life, most commonly presenting with haematuria and variations of ‘micturition attacks’. Eighty percent of tumours were functionally active. The mucosa was normal in 91% of patients. In all, 25% of tumours were treated with transurethral resection alone, 65% had partial cystectomy and 5% had radical cystectomy. Alpha-blockers were administered pre-operatively in 38% of patients and the risk of intra-operative hypertensive crisis was over three times greater in those who did not receive an alpha-blocker. The tumour was confined to the bladder in 75% of cases. Metastasis occurred in 20% of cases, most commonly to iliac nodes. The mean follow-up time was 26.5 months. In cases that documented follow-up, 18.6% had recurrence, most commonly in lymph nodes and bone. Conclusion: All patients presenting with micturition attacks or haematuria with a computed tomography showing an enhancing, well-defined submucosal bladder lesion and/or cystoscopy showing a lesion with normal overlying mucosa should be worked up for a possible paraganglioma of the urinary bladder. Level of evidence: Not applicable

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Micturitional headache in a young girl

Cited by 2 publications

References 13 publications

Urinary Bladder Paraganglioma in Childhood: A Case Report and Review of the Literature

Urinary Bladder Paraganglioma in Childhood: A Case Report and Review of the Literature

Paraganglioma (pheochromocytoma) of the urinary bladder: A systematic review with a diagnostic, management and treatment algorithm

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