Microwaves from UMTS/GSM mobile phones induce long‐lasting inhibition of 53BP1/γ‐H2AX DNA repair foci in human lymphocytes

Belyaev, Igor; Markovà, Eva; Hillert, Lena; Malmgren, Lars; Persson, Bertil

doi:10.1002/bem.20445

Cited by 67 publications

(51 citation statements)

References 56 publications

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“…Second, we could only evaluate the y-H2AX DNA repair foci in human lymphocytes, as an indicator of DNA damage. However, since it has been reported that DSB in the DNA is probably a consequence of radiation-induced changes in interaction between DNA and proteins (e.g., histones) (36), the evaluation of proteins involved in DNA repair and damage signaling, such as phosphorylated H2AX, is actually considered the most sensitive method to study DSB (37,38).…”

Section: Discussionmentioning

confidence: 99%

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

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Background: The use of mobile phones has been associated with an increased risk of developing certain type of cancer, especially in long term users. Therefore, this study was aimed to investigate the potential genotoxic effect of mobile phone radiofrequency exposure on human peripheral blood mononuclear cells in vitro. Methods:The study population consisted in 14 healthy volunteers. After collection of two whole blood samples, the former was placed in a plastic rack, 1 cm from the chassis of a commercial mobile phone (900 MHz carrier frequency), which was activated by a 30-min call. The second blood sample was instead maintained far from mobile phones or other RF sources. The influence of mobile phone RF on DNA integrity was assessed by analyzing γ-H2AX foci in lymphocytes using immunofluorescence staining kit on AKLIDES.Results: No measure of γ-H2AX foci was significantly influenced by mobile phone RF exposure, nor mobile phone exposure was associated with significant risk of genetic damages in vitro (odds ratio comprised between 0.27 and 1.00). Conclusions:The results of this experimental study demonstrate that exposure of human lymphocytes to a conventional 900 MHz RF emitted by a commercial mobile phone for 30 min does not significantly impact DNA integrity.

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Section: Discussionmentioning

confidence: 99%

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

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“…Changes in the conformation of chromatin and formation of 53BP1/gammaH2AX DNA repair foci were reported in lymphocytes from hypersensitive and healthy subjects following exposure to 915 MHz GSM and 1947 MHz UMTS signals [Belyaev et al, 2009]. The effects did not depend on the type of the signal.…”

Section: Review Of Experimental Observations Genotoxicitymentioning

confidence: 93%

Review of possible modulation‐dependent biological effects of radiofrequency fields

Juutilainen

Höytö

Kumlin

et al. 2011

Bioelectromagnetics

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The biological effects of modulated radiofrequency (RF) electromagnetic fields have been a subject of debate since early publications more than 30 years ago, suggesting that relatively weak amplitude-modulated RF electromagnetic fields have specific biological effects different from the well-known thermal effects of RF energy. This discussion has been recently activated by the increasing human exposure to RF fields from wireless communication systems. Modulation is used in all wireless communication systems to enable the signal to carry information. A previous review in 1998 indicated that experimental evidence for modulation-specific effects of RF energy is weak. This article reviews recent studies (published after 1998) on the biological effects of modulated RF fields. The focus is on studies that have compared the effects of modulated and unmodulated (continuous wave) RF fields, or compared the effects of different kinds of modulations; studies that used only one type of signal are not included. While the majority of recent studies have reported no modulation-specific effects, there are a few interesting exceptions indicating that there may be specific effects from amplitude-modulated RF fields on the human central nervous system. These findings warrant follow-up studies.

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“…Mobile phone frequency GSM exposure at the frequency of 915 MHz consistently inhibited DNA repair foci in lymphocytes (Markova et al 2005;Belyaev et al 2005Belyaev et al , 2009. Markova et al (2009) reported that very low-intensity microwave radiation from mobile phones inhibits DNA repair processes in human stem cells.…”

Section: Failure To Repair Dna Damage (Repair Mechanisms Not Triggerementioning

confidence: 99%

The similar effects of low-dose ionizing radiation and non-ionizing radiation from background environmental levels of exposure

Sage¹

2012

Environmentalist

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The meltdown and release of radioactivity (ionizing radiation) from four damaged nuclear reactors at the Fukushima Nuclear Facility in Japan in March 2011 continues to contaminate air and ocean water even 1 year later. Chronic exposure to low-dose ionizing radiation will occur over large populations well into the future. This has caused grave concern among researchers and the public over the very long period of time expected for decommissioning alone (current estimate from official sources is 30-40 years based on TEPCO in Mid-and long-term roadmap towards the decommissioning of Fukushima Daiichi nuclear power units 1-4, 2011) and the presumed adverse effects of chronic, lowdose ionizing radiation on children, adults and the environment. Ultimately, radioactive materials from Fukushima will circulate for many years, making health impacts a predictable concern for many generations (Yasunari et al. in PNAS 108(49):19530-19534, 2011). There is long-standing scientific evidence to suggest that low-dose ionizing radiation (LD-IR) and low-intensity non-ionizing electromagnetic radiation (LI-NIER) in the form of extremely low-frequency electromagnetic fields and radiofrequency radiation (RFR) share similar biological effects. Public health implications are significant for reconstruction efforts to rebuild in postFukushima Japan. It is relevant to identify and reduce exposure pathways for chronic, low-dose ionizing radiation in post-Fukushima Japan given current scientific knowledge. Intentional planning, rather than conventional planning, is needed to reduce concomitant chronic low-intensity exposure to non-ionizing radiation. These are reasonably well-established risks to health in the scientific literature, as evidenced by their classification by World Health Organization International Agency for Research on Cancer as Possible Human Carcinogens. Reducing preventable, adverse health exposures in the newly rebuilt environment to both LD-IR and LI-NIER is an achievable goal for Japan. Recovery and reconstruction efforts in Japan to restore the communications and energy infrastructure, in particular, should pursue strategies for reduction and/or prevention of both kinds of exposures. The design life of buildings replaced today is probably 35-50 years into the future. Cumulative health risks may be somewhat mitigated if the double exposure (to both chronic low-dose IR from the Fukushima reactors and LI-NIER [EMF and RFR] in new buildings and infrastructure) can be dealt with effectively in early planning and design in Japan's reconstruction.

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Microwaves from UMTS/GSM mobile phones induce long‐lasting inhibition of 53BP1/γ‐H2AX DNA repair foci in human lymphocytes

Cited by 67 publications

References 56 publications

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Review of possible modulation‐dependent biological effects of radiofrequency fields

The similar effects of low-dose ionizing radiation and non-ionizing radiation from background environmental levels of exposure

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