Microwaves for breast cancer detection?

Fear, Elise C.; Meaney, Paul M.; Stuchly, M.A.

doi:10.1109/mp.2003.1180933

Cited by 345 publications

(193 citation statements)

References 10 publications

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“…[4][5][6][7][8] Microwave ablation method is much safer and easily manageable 9 and can, in principle, offer material-specific responsiveness, where tissues with high water content such as cancer are preferentially heated and damaged. 10,11 This characteristic of microwaves makes microwave ablation well suited for local treatment of early stage of breast cancer. So far, the frequencies used in the existing microwave ablation systems have been limited to the low-frequency spectrum such as 915 MHz or 2.4 GHz.…”

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confidence: 99%

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Yoon

Cho

Kim

et al. 2011

Intl Journal of Cancer

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To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.Breast cancer is a major threat to women's health psychologically as well as physically. 1 Despite the high potential of fatality, most women show reluctance for large-scale breast removal due to cosmetic concerns, which brings about the need for local surgical control. For this reason, minimally invasive techniques to achieve better local surgical control have collected extensive attention as a possible first-line treatment in lieu of conservative breast surgery procedures such as lumpectomy. 2,3 Among several alternative methods, microwave ablation entails many benefits in comparison with the others such as laser ablation, cryoablation and ethanol ablation. [4][5][6][7][8] Microwave ablation method is much safer and easily manageable 9 and can, in principle, offer material-specific responsiveness, where tissues with high water content such as cancer are preferentially heated and damaged. 10,11 This characteristic of microwaves makes microwave ablation well suited for local treatment of early stage of breast cancer. So far, the frequencies used in the existing microwave ablation systems have been limited to the low-frequency spectrum such as 915 MHz or 2.4 GHz. Because of the inherent low radiation efficiency, very high microwave input power of several tens of Watts is required at these frequencies, thus greatly increasing the cost and size of the equipment. 12 Moreover, because of the self-heating of the applicator by the excessive microwave power, additional means for cooling the applicator are required to avoid the damage of healthy tissues near the passage of the applicator. 13 Besides, the conventional low-frequency spectrum ablation has poor material selectivity when compared to the alternative high-frequency spectrum proposed in our work.To overcome the limitations of the existing microwave ablation methods, we have investigated the properties of microwaves up to 30 GHz wit...

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confidence: 99%

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Yoon

Cho

Kim

et al. 2011

Intl Journal of Cancer

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“…Such methods typically fall into one of three categories: tomography, holography, or radar. In tomographic methods, the goal is to reconstruct a dielectric profile of the breast tissues [3]. In microwave holography, coherent back-scattered signals acquired on apertures are used to reconstruct the target [4].…”

Section: Introductionmentioning

confidence: 99%

“…In microwave holography, coherent back-scattered signals acquired on apertures are used to reconstruct the target [4]. Alternatively, radar methods attempt to map regions of dielectric scattering, from which the tissue type can be inferred [3].…”

Section: Introductionmentioning

confidence: 99%

Time-Domain Microwave Radar Applied to Breast Imaging: Measurement Reliability in a Clinical Setting

Porter¹,

Santorelli²,

Popović³

2014

PIER

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Abstract-This work presents an evaluation of the measurement challenges in clinical testing of our microwave breast cancer screening system. The time-domain radar system contains a multistatic 16-antenna hemi-spherical array operating in the 2-4 GHz frequency range. We investigate, for the first time with such a system in clinical trials, the repeatability of measurements and its effect on image reconstruction. We record vertical and horizontal measurement uncertainties under different scenarios and verify using previously introduced compensation methods that they can be successfully reduced to an acceptable level from the standpoint of image reconstruction. We also examine how placement of an immersion medium can affect collected breast scan data. Finally, we probe the repeatability and consistency of measurements with patients. With the goal of confirming the feasibility of frequent breast health monitoring, with our system, we obtain a total of 342 breast scans collected over 57 patient visits to determine how much scan data varies when there are no changes in between scans, and how much it varies when the patient is repositioned in the system. We confirm that, by taking care in patient positioning in the system and with respect to the immersion medium, the measurement repeatability is high.

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“…Motivated by the high contrast between malignant tumor tissue and the normal surrounding breast tissue in electrical properties (such as permittivity and conductivity), microwave imaging technology has attracted much attention because it is non-ionizing, more comfortable, more accurate and less expensive [3]. Except for common hardware components, such as signal generator, antenna array and data sampling equipments (for example, vector network analyser (VNA) or oscilloscope), imaging algorithm and software play a very important role on the performance and detection capability of microwave imaging system.…”

Section: Introductionmentioning

confidence: 99%

Energy Estimation Based Tr-Music Microwave Imaging for Extended Targets

Zhang¹,

Wang²,

Wang³

2013

PIER B

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Abstract-A simple and effective double-thresholding strategy based on energy estimation is proposed to choose the optimal boundary between the signal subspace and noise subspace in TR-MUSIC algorithm for microwave imaging of extended targets. Simulations and imaging results are given to demonstrate its strong noise rejection and super-resolution capability. In the new method, the shape details of extended targets can be obtained from single frequency or multifrequency scattering data.

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Microwaves for breast cancer detection?

Cited by 345 publications

References 10 publications

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Time-Domain Microwave Radar Applied to Breast Imaging: Measurement Reliability in a Clinical Setting

Energy Estimation Based Tr-Music Microwave Imaging for Extended Targets

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