Microwave Plasma Sintering and In Vitro Study of Porous HA/β-TCP Biphasic Bioceramics

Ji, Jin Gou; Ran, Jun Guo; Gou, Li; Wang, Fang Hu; Sun, Lu Wei

doi:10.4028/0-87849-959-8.1519

Cited by 1 publication

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“…rate. 123,129,130,140,147 However, these materials hold little clinical utility due to their poor mechanical properties discussed above. Natural polymers such as collagen, fibrin, alginate, gelatin, and GAGs have also been extensively investigated as drug delivery vehicles in bone tissue engineering.…”

Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

532

485

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

532

485

View full text Add to dashboard Cite

show abstract

Microwave Plasma Sintering and In Vitro Study of Porous HA/β-TCP Biphasic Bioceramics

Cited by 1 publication

References 0 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

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