Microwave induced synthesis of thieno[2,3-b]quinoline-2-carboxylic acids and alkyl esters and their antibacterial activity

Microwave Induced One-Pot Synthesis of Some New Thiopyrano[2,3-b]quinolin-2-ones under Solvent-Free Conditions

“…Hence, in continuation of our studies in the synthesis of condensed quinoline derivatives, [15][16][17][18] due to their significant biological activities, it appeared expedient to synthesize a condensed quinoline that is presented here in the present study.…”

Recent Advances in the Synthesis of Thienoquinolines (Quinoline‐fused heterocycle)

“…(Scheme 6) In 2005, Naik and co-workers successively reported a microwave method for the synthesis of thieno[2,3-b]quinoline-acid and ester analogs 30, from 2-chloro-3-formyl quinolines 28. [24] Firstly, chlorine at the C-2 position of compound 28 could be reacted with thioglycolic acid/esters in the presence of anhydrous K 2 CO 3 In 2013, Rao and co-workers described a DBU catalyzed new class of thieno[2,3-b]quinolines 32 from substituted 2-chloro-3formyl quinolines 31. [25] The starting substrate 31 is achieved according to the previous literature procedure, [26] Next, reacted with methyl 2-mercapto acetate by using DBU and THF at room temperature to access thieno[2, 3- Morita-Baylis-Hillman/alkylation/aldol-condensation (AMBH) pathway.…”

Utility of N′‐((2‐chloroquinolin‐3‐yl)methylene)‐2‐cyanoacetohydrazide as a Source of Biologically Active Novel Heterocycles

“…Quinolines and their derivatives are very important in medicinal chemistry because of their wide occurrence in natural products and drugs . They have a wide range of pharmacological activities, such as cardiotonic , anticonvulsant , anti‐inflammatory , analgesic , antiviral , anticancer , antiobesity , antibacterial , antifungal , and anthelmintic . The quinoline derivatives are extensively used as antibiotics in eradicating many infections .…”