Microwave-hydrothermal synthesis of stable nanocrystalline ceria sols for biomedical uses

The combined action of ceria nanoparticles and doxorubicin on the early stages of ontogenesis of Danio rerio and Puntius tetrazona was studied. Results obtained indicate that there is a synergetic effect of CeO 2 nanoparticles and doxorubicin which is demonstrated by a high incidence of embryonic malformations in fish. This synergetic effect is more pronounced in tiger barbs than in zebrafish, and depends strongly on the synthetic route of ceria nanoparticles' preparation, the most notable effects being registered for citrate-stabilized nanoparticles.

Section: Methodsmentioning

confidence: 99%

Synergetic action of ceria nanoparticles and doxorubicin on the early development of two fish species, Danio rerio and Puntius tetrazona

Krysanov¹,

Демидова²,

Ivanova³

et al. 2019

“…Cerium oxide nanoparticles (CeONP, size ∼ 5.8 nm, ζ-potential ∼ +12 mV) were synthesized as an aqueous 0.01 M sol [12].…”

Section: Cerium Oxide Nanoparticles and Tumor Necrosis Factormentioning

confidence: 99%

Сerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro

Shydlovska¹,

Kharchenko²,

Zholobak³

et al. 2018

Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-α and recombinant tumor necrosis factor-α-thymosin-α1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.

“…• C for 3 h [11], D -sample prepared using polyacrylate as stabilizer and further treated hydrothermally at 180…”

Section: Figmentioning

confidence: 99%

“…To date, several methods that would satisfy the denoted criteria have been developed for the synthesis of CDNs, in which the CDNs could form biocompatible sols suitable for nanopharmaceutical applications (some examples are shown in Fig. 3) [10][11][12][13][14]. The conditions of CeO 2 nanoparticle formation were studied, especially their impact on the characteristics of the formed particles, such as size, degree of crystallinity, oxygen stoichiometry, stability and ζ-potential, as well as other parameters that determine the behaviour of the particles in biological systems [9,15].…”

Section: Introductionmentioning

confidence: 99%

Cerium dioxide nanoparticles as third-generation enzymes (nanozymes)

Попов¹,

Shcherbakov²,

Zholobak³

et al. 2017

Ceria nanoparticles are capable of performing the function of some enzymes (such as oxidoreductases, phosphatase) and can be classified as nanozymes. In this review, the actual data on the enzymatic activity of ceria were critically analyzed and specific conditions under which the cerium dioxide nanoparticles can act as enzymes were defined. The presented analysis may be useful in the planning, design and synthesis of ceria nanoparticles having the desired enzymatic functions required for various processes, including the development of the nanodrugs, which exhibit the therapeutic effect depending on their composition and pH of media, development of molecular sensors and biosensors, etc.