Сerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro

Abstract

Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-α and recombinant tumor necrosis factor-α-thymosin-α1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

“…In addition, the manufacturing of liposomal products employs rather sophisticated technologies. Various inorganic nanoscale objects are considered as components of targeted drug delivery systems; these include metal, oxide or complex oxide objects, and some other types of nanoparticles [14][15][16][17][18][19][20][21][22][23][24][25], as well as carbon clusters (fullerenes, nanotubes, graphene, and nanodiamonds) . These objects can be used, for instance, as shells or cores of nanocapsules, providing the release of drugs, for example, under local electromagnetic influence.…”

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

“…In some cases, the factor contributing to the release of the transported drug from the nanocapsules may be the changing pH of the medium into which they find themselves. By their composition, the metal-containing biomedical nanoparticles are usually divided into purely metallic, e.g., gold copper, silver, and nanoparticles with a complex composition, for example, based on oxides of iron, copper, zinc, titanium, tungsten, on cerium and zirconium dioxides, including those containing rare earth metals [70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86], etc.…”

Synthesis and biocompatibility study of ceria-mildronate nanocomposite in vitro

“…The nanoceria-curcumin conjugate demonstrated highly selective cytotoxicity under oxidative stress conditions induced by UVA/UVC irradiation or H 2 O 2 , causing a dramatic inhibition of metabolic activity of cancer cells and protecting normal cells from these damaging factors [38]. The combination of recombinant TNF-alpha with cerium dioxide nanoparticles has been shown to provide a stronger and more stable cytotoxic effect in Hep-2 and A-549 tumor cell lines [39]. Thus, the design and study of hybrid ceriumcontaining nanocomposites could be a promising tool for creating advanced functional materials with a therapeutic activity exceeding that of the individual components (synergism).…”