Microwave‐Enhanced Radiochemistry

Tritium chemistry: history, current status and future developments; a brief review

“…21a-c,22d With the recent availability of similar commercial systems further advances are anticipated. 21b,c In addition, the convenience of modern automated microwave systems 23 promises to revolutionize radiochemical preparations and speed up the search for new labelling catalysts. 17b, 24 An interesting area with potential applications in tritium chemistry is that of microreactors, 25a,b though these have so far only been applied to deuterium and b + emitters.…”

Synthesis and in vitro evaluation of 18F‐labelled di‐ and tri(ethylene glycol) metomidate esters

“…15,16 Microwave heating was performed on compounds 3 and 4 using different temperatures and solvents to find the optimized reaction condition (Tables 2 and 3). The reactions were heated in the microwave oven for periods of 2-120 s and the samples were collected from the reaction mixtures at different time points and HPLC-analysed (Tables 2 and 3).…”

Novel solvent‐free labelling procedure with carbon‐14 diethyl malonate

“…Mild reaction conditions, easy purification, improved waste management and kinetic enhancements achieved in preparations using this technique in combination with microwave activation 2 are of considerable benefit also for short half-life isotope radiochemistry. 3,4 In this work, solvent-free synthesis using solid-liquid phase transfer catalysis (PTC) conditions for carbon-14 labelling with diethyl malonate is described. This leads to a novel one-pot procedure for ester preparations involving diethyl malonate alkylation followed by dealkoxycarbonylation.…”